Vitamin B12 supplementation improves heart rate variability in healthy elderly Indian subjects

Sucharita, S; Thomas, Tinku; Antony, Benny; Vaz, Mário

doi:10.1016/j.autneu.2011.12.002

Cited by 16 publications

(12 citation statements)

References 37 publications

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“…Vaz et al . () hypothesized that lowered HRV response may be related to deficiencies of vitamin B12, as reported in previous studies (Aytemir et al ., ; Beitzke et al ., ; Sucharita et al ., ), or reduction in T3, as evidenced in an animal model system where UW was associated with a reduction in baroceptive reflex sensitivity (Foley et al ., ). However, if changes in the baroceptive reflex sensitivity could be a possible reason for both the reduction of the HF band and the reduction of parasympathetic components in the LF band, the young age of the study population and the lack of hypertension and vascular diseases make this explanation unlikely.…”

Section: Discussionmentioning

confidence: 99%

Heart rate variability is reduced in underweight and overweight healthy adult women

Triggiani

Valenzano

Ciliberti

et al. 2015

Clin Physio Funct Imaging

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Heart rate variability (HRV) is altered in obese subjects, but whether this is true also in underweight (UW) subjects is still under debate. We investigated the HRV profile in a sample of healthy adult women and its association with adiposity. Five-minute resting state electrocardiographic activity was recorded in 69 subjects grouped according to their body mass index, [23 normal weight (NW), 23 overweight/obese (OW) and 23 UW). Body fat mass (FM) was measured by bio-impedance. Frequency- and time-domain analyses were performed. Compared to NW, UW and OW subjects showed a significant decrease in HRV indices, as revealed by spectral analysis. No differences were observed between UW and OW subjects. A second-order polynomial regression unveiled an inverted U-shaped relationship between FM extent and HRV indices. A decrease of HRV indices was associated with changes in FM extent, proving that in UW and OW subjects, the adaptive flexibility of autonomic cardiac function was reduced. These findings provide important clues to guide future studies addressed to determine how changes in adiposity and autonomic cardiac function may contribute to health risk.

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Section: Discussionmentioning

confidence: 99%

Heart rate variability is reduced in underweight and overweight healthy adult women

Triggiani

Valenzano

Ciliberti

et al. 2015

Clin Physio Funct Imaging

View full text Add to dashboard Cite

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“…Vitamin B-12-deficient individuals in one study had a lower CMAP and nerve conduction velocity (measured between popliteal fossa and ankle) (24), but it is notable that vitamin B-12 deficiency was defined as vitamin B-12 ,260 pmol/L and elevated MMA, the latter of which might be important. A second cross-sectional study measured sensory and motor nerve conduction velocity in the median nerve and reported no association with vitamin B-12 status (depletion defined as serum B-12 ,148 pmol/L) (25). Nevertheless, a recent pre-and posttreatment study in asymptomatic older adults with serum vitamin B-12 ,120 pmol/L (26) reported an improvement in sensory latency (peripheral nerve conductivity) for left and right sural nerves and of the right median nerve, but not SAP amplitudes for these nerves, 4 mo after a single dose of an intramuscular treatment of 10 mg vitamin B-12, 100 mg pyridoxine, and 100 mg thiamine.…”

Section: Comparison With Other Studiesmentioning

confidence: 99%

Vitamin B-12 status and neurologic function in older people: a cross-sectional analysis of baseline trial data from the Older People and Enhanced Neurological Function (OPEN) study,

Miles

Allen

Mills

et al. 2016

The American Journal of Clinical Nutrition

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Background: Aging is associated with a progressive decline in vitamin B-12 status. Overt vitamin B-12 deficiency causes neurologic disturbances in peripheral and central motor and sensory systems, but the public health impact for neurologic disease of moderately low vitamin B-12 status in older people is unclear. Evidence from observational studies is limited by heterogeneity in the definition of vitamin B-12 status and imprecise measures of nerve function. Objective: We aimed to determine whether vitamin B-12 status is associated with electrophysiologic indexes of peripheral or central neurologic function in asymptomatic older people with moderately low vitamin B-12 status. Design: We used a cross-sectional analysis of baseline data from the Older People and Enhanced Neurological Function study conducted in Southeast England. This trial investigated the effectiveness of vitamin B-12 supplementation on electrophysiologic indexes of neurologic function in asymptomatic older people (mean age: 80 y) with moderately low vitamin B-12 status (serum vitamin B-12 concentrations $107 and ,210 pmol/L without anemia, n = 201). Vitamin B-12 status was assessed with the use of total vitamin B-12, holotranscobalamin, and a composite indicator of vitamin B-12 status (cB-12). Electrophysiologic measures of sensory and motor components of peripheral and central nerve function were assessed in all participants by a single observer. Results: In multivariate models, there was no evidence of an association of vitamin B-12, holotranscobalamin, or cB-12 with any nerve conduction outcome. There was also no evidence of an association of vitamin B-12 status with clinical markers of neurologic function. Conclusion: This secondary analysis of high-quality trial data did not show any association of any measure of vitamin B-12 status with either peripheral or central neurologic function or any clinical markers of neurologic function in older people with moderately low vitamin B-12 status. The results of this study are unlikely to be generalizable to a less healthy older population with more severe vitamin B-12 deficiency. This trial was registered at www. controlled-trials.com as ISRCTN54195799.Am J Clin Nutr 2016;104:790-6.

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“…Twelve reports from ten studies (two longitudinal and ten cross-sectional analyses) met the inclusion criteria. Of these, six were conducted in Europe ( 20 – 27 ) , with the remaining studies conducted in the USA ( 28 ) , Asia ( 29 , 30 ) and Australia ( 31 ) . Of the European articles, three were from Denmark with overlapping samples of participants from the same study ( 20 – 22 ) .…”

Section: Resultsmentioning

confidence: 99%

“…One cross-sectional analysis ( 28 ) with a low risk of bias suggested an association of low vitamin B 12 status with some, but not all, electrophysiological measures of nerve function. One small cross-sectional analysis ( 29 ) with an identified risk of bias found no association of vitamin B 12 status and electrophysiological measures of nerve function. Five further cross-sectional studies with low ( 24 , 26 ) or identified ( 27 , 30 , 31 ) risk of bias reported clinically measured signs and symptoms of neuropathy and self-reported neurological symptoms, and provided mixed results.…”

Section: Resultsmentioning

confidence: 99%

Is there an association of vitamin B₁₂status with neurological function in older people? A systematic review

et al. 2015

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Low vitamin B 12 status is common in older people; however, its public health significance in terms of neurological manifestations remains unclear. The present systematic review evaluated the association of vitamin B 12 status with neurological function and clinically relevant neurological outcomes in adults aged 50þ years. A systematic search of nine bibliographic databases (up to March 2013) identified twelve published articles describing two longitudinal and ten cross-sectional analyses. The included study populations ranged in size (n 28 -2287) and mean/median age (range 65-81 years). Studies reported various neurological outcomes: nerve function; clinically measured signs and symptoms of nerve function; self-reported neurological symptoms. Studies were assessed for risk of bias, and results were synthesised qualitatively. Among the general population groups of older people, one longitudinal study reported no association, and four of seven cross-sectional studies reported limited evidence of an association of vitamin B 12 status with some, but not all, neurological outcomes. Among groups with clinical and/or biochemical evidence of low vitamin B 12 status, one longitudinal study reported an association of vitamin B 12 status with some, but not all, neurological outcomes and three cross-sectional analyses reported no association. Overall, there is limited evidence from observational studies to suggest an association of vitamin B 12 status with neurological function in older people. The heterogeneity and quality of the evidence base preclude more definitive conclusions, and further high-quality research is needed to better inform understanding of public health significance in terms of neurological function of vitamin B 12 status in older people.Key words: Vitamin B 12 : Neurological function: Nerve conduction: Older people Ageing is associated with a decline in vitamin B 12 status (1,2) , and there is widespread evidence of low vitamin B 12 status in older people (1,3) . In the UK, 5 % of adults aged 65 -74 years and 10 % adults aged $75 years have low vitamin B 12 levels (defined as vitamin B 12 , 150 pmol/l) or metabolically significant vitamin B 12 deficiency (defined as vitamin B 12 , 200 pmol/l and homocysteine level . 20 mmol/l) (1) . However, intakes of vitamin B 12 in adults are mostly adequate and in the most recent National Diet and Nutrition Survey of the UK, only 1 % of adults aged 65 -74 years and $75 years had vitamin B 12 intakes below the lower reference nutrient intakes (4) . Several factors relating to vitamin B 12 absorption may contribute to poor status in older people, including a decrease in gastric acidity, the presence of atrophic gastritis, compromised functional and structural integrity of vitamin B 12 -binding proteins, and lack of liver vitamin B 12 stores (5) .Indeed, food-cobalamin malabsorption can account for up to 60 -70 % of confirmed cases of vitamin B 12 deficiency in older people (6) .The clinical manifestations of vitamin B 12 deficiency can be haematological, neur...

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Vitamin B12 supplementation improves heart rate variability in healthy elderly Indian subjects

Cited by 16 publications

References 37 publications

Heart rate variability is reduced in underweight and overweight healthy adult women

Heart rate variability is reduced in underweight and overweight healthy adult women

Vitamin B-12 status and neurologic function in older people: a cross-sectional analysis of baseline trial data from the Older People and Enhanced Neurological Function (OPEN) study,

Is there an association of vitamin B₁₂status with neurological function in older people? A systematic review

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Vitamin B12 supplementation improves heart rate variability in healthy elderly Indian subjects

Cited by 16 publications

References 37 publications

Heart rate variability is reduced in underweight and overweight healthy adult women

Heart rate variability is reduced in underweight and overweight healthy adult women

Vitamin B-12 status and neurologic function in older people: a cross-sectional analysis of baseline trial data from the Older People and Enhanced Neurological Function (OPEN) study,

Is there an association of vitamin B12status with neurological function in older people? A systematic review

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Is there an association of vitamin B₁₂status with neurological function in older people? A systematic review