Vitamin B2 enhances development of puberty ovaries via regulation of essential elements and plasma endocrine hormones

Abstract

Purpose: To investigate the effect of vitamin B2 (VB2) on ovarian development during puberty. Methods: Four groups of domestic hens (Jinghong-1 strain, 12 hens/group) were housed under standard conditions and fed basal diet with or without graded doses of VB2 (10-40 mg/kg). At 10 weeks old, 9 hens were sacrificed from each group. Plasma levels of AST, ALT, steroid hormones and growth hormones were determined. In addition, some essential mineral elements in the ovarian tissue of the hens were assayed. Results: Treatment with VB2 significantly improved ovary and liver organ indices (p < 0.01), but had no deleterious effect on the liver. The different doses of VB2 exerted regulatory effects on homeostasis of essential elements in the ovary (p < 0.01). Moreover, VB2 treatment elevated plasma levels of progesterone (PR) and estrogen (ES), suggesting that it might regulate steroid hormone levels. Conclusion: These results indicate that VB2 enhances the development of the ovaries during puberty.

Integrated Transcriptomic and Metabolomic Profiling of Sheep Ovarian Tissues Confer their association in Fecundity associated Pathways

“…Previous studies also reinforce our findings, like pregnancy interruption due to deficiency of riboflavin was reported by [57, 58], their strong antioxidant roles mediated by free radicals was witnessed by [59]. In previous studies it has been observed the involvement of VB2 in ovarian development [60], bioenergetics pathways, redox homeostasis, chromatin remodeling [61, 62], deoxyribonucleic acid (DNA) repair mechanisms [63] and cell growth, and apoptosis [64, 65] which is in agreement to our findings of upregulated VB2 expression. ROC-AUC value determined that riboflavin (pos_4) may act as a potential biomarker for oxidative stress.…”