Vitamin B6 status improves in overweight/obese women following a hypocaloric diet rich in breakfast cereals, and may help in maintaining fat-free mass

Abstract

Objective: To analyze the changes in vitamin B 6 status in women following slightly hypocaloric diets based on the relative increase consumption of foods whose intakes are below those recommended, and to study how these changes influence the proportion of fat-free mass. Design: Intervention study of two slightly hypocaloric diets: diet V (increased consumption of vegetables), or diet C (increased consumption of cereals, especially breakfast cereals). Subjects: A total of 49 women with a body mass index (BMI) of 25-35 kg/m 2 . Measurements: Dietetic, anthropometric and biochemical data were collected at the start of the study and at 2 and 6 weeks. Results: Both the C and V subjects showed a reduction in their energy intake, body weight, BMI and fat mass. Pyridoxine intake increased in both groups and plasma pyridoxal phosphate (PLP) levels increased only with diet C. An association was found between the increase in plasma PLP at 6 weeks and the increase in pyridoxine intake (r ¼ 0.451; Po0.01). Multiple regression analysis showed a positive association between the increase in PLP at the end of the study and the increases in the pyridoxine intake, B 6 density or B 6 /protein ratio. At the end of the study, and only in those women whose PLP levels were increased, the higher the increase in PLP level, the higher the increase in fat-free mass percentage (r ¼ 0.4426, Po0.05) Conclusions: Interventions aimed at weight control should also try to maintain or improve nutritional status. A diet rich in cereals (especially fortified breakfast cereals) appears to be useful in improving vitamin B 6 status. Such an improvement could help maintain fat-free mass during periods of weight loss.

The long-term effect of a protein-deficient-diet enriched with vitamin B6 on the blood parameters in unexercised and exercised rats

“…These data are consistent with our previously published study (Lewicka et al, 2012). Rodríguez-Rodríguez et al (2008) showed that vitamin B6 lessens the negative effect of hypocaloric diet and helps maintaining fat-free mass in overweight/obese women. A similar correlation was observed by Debski, Bertrandt, Klos, and Gralak (2007).…”

Experimental immunology The effect of vitamin B 6 supplementation of protein deficiency diet on hematological parameters in the blood of rats subjected/non subjected to physical exertion – a pilot study

“…There are a several evidences that B 6 vitamin deficiency decreased body mass in rats [18,19]. In addition, B 6 supplementation improves status of overweight or obese woman [20]. Unfortunately, we didn't find in world literature articles dedicated to the effect of vitamin B 6 supplementation on gain weight.…”

Dietary Intake of Vitamin B-6, Plasma Pyridoxal 5′-Phosphate, and Homocysteine in Puerto Rican Adults

“…Previous studies have shown that vitamin B6 from oral supplements can be absorbed quickly, resulting in significant increases in plasma PLP (42). Many ready-to-eat cereals have been fortified with vitamin B6, and these have been shown to improve plasma PLP concentration (10, 43). …”