Vitamin B6 supplementation increases immune responses in critically ill patients

Cheng, Chun-Wen; Chang, Sue-Joan; Lee, B. J.; Lin, Karin; Huang, Yann-Chang

doi:10.1038/sj.ejcn.1602439

Cited by 79 publications

(48 citation statements)

References 20 publications

(34 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Supplementation of vitamin B 6 seemed to be beneficial for improving immune responses (Casciato et al, 1984;Talbott et al, 1987;Folkers et al, 1993;Cheng et al, 2006). In addition to the relationship between vitamin B 6 status and inflammatory responses, it would thus be useful to know whether a high dose of vitamin B 6 supplement would also increase the immune response of patients with RA.…”

Section: Introductionmentioning

confidence: 99%

Vitamin B6 supplementation improves pro-inflammatory responses in patients with rheumatoid arthritis

Wei

et al. 2010

Eur J Clin Nutr

Self Cite

112

View full text Add to dashboard Cite

Background/Objectives: The purpose of this study was to investigate whether vitamin B 6 supplementation had a beneficial effect on inflammatory and immune responses in patients with rheumatoid arthritis (RA). Subjects/Methods: This was a single-blind co-intervention study performed at the Division of Allergy, Immunology and Rheumatology of Chung Shan Medical University Hospital, Taiwan. Patients were diagnosed with RA according to the 1991 American College of Rheumatology criteria for RA. Patients were randomly allocated into two groups: control (5 mg/day folic acid only; n ¼ 15) or vitamin B 6 (5 mg/day folic acid plus 100 mg/day vitamin B 6 ; n ¼ 20) for 12 weeks. Plasma pyridoxal 5 0 -phosphate (PLP), serum folate, inflammatory parameters (that is, high-sensitivity C-reactive protein (hs-CRP), erythrocyte sedimentation rate (ESR), interleukin-6 (IL-6), tumor necrosis factor-a (TNF-a)) and immune parameters (that is, white blood cell, total lymphocyte, T-cell (CD3), B-cell (CD19), T-helper cell (CD4), T-suppressor (CD8)) were measured on day 1 (week 0) and after 12 weeks (week 12) of the intervention. Results: In the group receiving vitamin B 6 , plasma IL-6 and TNF-a levels significantly decreased at week 12. There were no significant changes with respect to immune responses in both groups except for the percentage of total lymphocytes in the vitamin B 6 group when compared with week 0 and week 12. Plasma IL-6 level remained significantly inversely related to plasma PLP after adjusting for confounders (b ¼ À0.01, P ¼ 0.01). Conclusions: A large dose of vitamin B 6 supplementation (100 mg/day) suppressed pro-inflammatory cytokines (that is, IL-6 and TNF-a) in patients with RA.

show abstract

Section: Introductionmentioning

confidence: 99%

Vitamin B6 supplementation improves pro-inflammatory responses in patients with rheumatoid arthritis

Wei

et al. 2010

Eur J Clin Nutr

Self Cite

112

View full text Add to dashboard Cite

show abstract

“…In contrast, critically ill patients often receive nutritional support (enteral, parenteral, or combined nutrition) or get micronutrient supplements, and thus they might have sufficient mean vitamin B-6 intake with a mean intake ranging from 2.4 to 16.3 mg/day (Cheng et al 2006;Huang et al 2002;Huang et al 2005). In the absence of evidence showing clinically inadequate vitamin B-6 intake in critically ill patients, deficient vitamin B-6 status in such patients in the intensive care unit may not be a concern.…”

Section: Vitamin B-6 Intake and Requirement In Critical Carementioning

confidence: 93%

“…To the best of authors' knowledge, only one study to date has been conducted on critically ill patients. The results showed that 50 mg or 100 mg/day of vitamin B-6 (pyridoxine-HCl) via IV injection could compensate for the lack of responsiveness of plasma PLP to vitamin B-6 intake and further increase immune responses of critically ill patients (Cheng et al 2006). Although more research is needed to conclusively demonstrate the effects of vitamin B-6 supplementation on critically ill patients, improvements in immune response appear to occur with high doses of vitamin B-6 supplementation (>50 mg/day pyridoxine), even in subjects with no evidence of vitamin B-6 deficiency.…”

Section: Vitamin B-6 and Immune In Critical Carementioning

confidence: 97%

Inadequate Vitamin B-6 Status in Critical Care

Huang¹,

Cheng²

2015

Diet and Nutrition in Critical Care

View full text Add to dashboard Cite

“…According to a study of immune dysregulation of RA, lower PLP inhibits thymidylate synthase and further impairs DNA synthesis [32]. Our previous studies also showed that there was a significant link between plasma PLP and immune responses [19,20]. Insufficient PLP supply, therefore, would impair the synthesis of DNA and RNA and further compromise immune responses.…”

Section: Discussionmentioning

confidence: 99%

“…Low circulating levels of plasma pyridoxal 5′-phosphate (PLP), the physiologically active coenzyme form of vitamin B 6 , have been observed in some patients with RA when compared to healthy controls [9,10,11,12] and have been inversely associated with TNF-α production by peripheral blood mononuclear cells in RA patients [9]. Plasma PLP has been shown to be significantly associated with increased CRP levels in patients with inflammatory diseases [9,13,14,15], and has a significant effect on immune responses [16,17,18,19,20]. Since PLP may act as a coenzyme for the production of cytokines and other polypeptide mediators during the inflammatory response [21] and low plasma PLP is associated with impairment in the differentiation and maturation of monocyte-derived macrophages and T lymphocytes [17,22], patients with RA experience chronic inflammatory conditions and immune dysregulation which may possibly increase the utilization and metabolic turnover of plasma PLP.…”

Section: Introductionmentioning

confidence: 99%

Plasma Pyridoxal 5′-Phosphate Is Not Associated with Inflammatory and Immune Responses after Adjusting for Serum Albumin in Patients with Rheumatoid Arthritis: A Preliminary Study

Huang

Wei²,

Lin³

et al. 2012

Ann Nutr Metab

View full text Add to dashboard Cite

Background/Aims: Plasma pyridoxal 5′-phosphate (PLP) has been shown to be associated with inflammatory and immune responses.Rheumatoid arthritis (RA) is an autoimmune and chronic systemic inflammatory disease and patients with RA have lower plasma PLP levels. We studied the relationship between plasma PLP and inflammatory or immune responses in patients with RA. Methods: This study was designed as an observational cross-sectional study. Forty-three patients with RA were allocated to the adequate (PLP ≥20 nmol/l) (n = 30) or deficient vitamin B₆ (PLP <20 nmol/l) (n = 13) group according to their fasting plasma PLP concentration on the day blood was taken. Plasma PLP, inflammatory parameters [i.e. high-sensitivity CRP (hs-CRP), erythrocyte sedimentation rate, interleukin-6, tumor necrosis factor-α] and immune parameters (i.e. white blood cells, total lymphocytes, neutrophils, T lymphocytes, B lymphocytes, T helper cells and T suppressor cells) were measured. Results: Patients with deficient plasma PLP concentration were mostly considered to have a systemic inflammatory status (hs-CRP >3 mg/l) and apparently had significantly higher mean hs-CRP levels and immune parameters than patients with adequate plasma PLP concentration. There was no significant association between plasma PLP levels and inflammatory parameters. The significantly inverse correlation of plasma PLP with the numbers of white blood cells, neutrophils, total lymphocytes, T lymphocytes and T helper cells remained after adjusting for serum hemoglobin concentration, but the significant correlation disappeared after serum albumin concentration was also considered. Conclusions: RA patients with deficient plasma PLP concentration had more severe inflammatory and immune responses than patients with adequate plasma PLP concentration. However, there was a lack of association of low plasma PLP concentration with inflammatory and immune parameters after serum albumin concentration was considered in patients with RA.

show abstract

Vitamin B6 supplementation increases immune responses in critically ill patients

Cited by 79 publications

References 20 publications

Vitamin B6 supplementation improves pro-inflammatory responses in patients with rheumatoid arthritis

Vitamin B6 supplementation improves pro-inflammatory responses in patients with rheumatoid arthritis

Inadequate Vitamin B-6 Status in Critical Care

Plasma Pyridoxal 5′-Phosphate Is Not Associated with Inflammatory and Immune Responses after Adjusting for Serum Albumin in Patients with Rheumatoid Arthritis: A Preliminary Study

Contact Info

Product

Resources

About