Vitamin B6status and Administration During Radiation Therapy

Ladner, H.-A.; Salkeld, Richard

doi:10.1007/978-1-4612-5006-7_27

Cited by 2 publications

(1 citation statement)

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“…Pyridoxine reduces vincristine-induced neuropathy in mice,52 although this effect has not yet been reproduced in adult humans.53 For various animal models and for adult humans, it has been proposed that vitamin B6 supplementation might improve tolerance of radiation therapy. 54 There is no established role for the use of vitamin B6 supplementation in the supportive care of children with leukemia. Although the differences in plasma PLP levels between patients and controls are clearly statistically significant, one can only speculate on whether or not these differences contribute to the morbidity of childhood leukemia.…”

Section: Discussionmentioning

confidence: 99%

Abnormal vitamin B6 status in childhood leukemia

Pais

Vanous

Hollins

et al. 1990

Cancer

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Vitamin B6 is involved in many biological processes of potential relevance to carcinogenesis and tumor growth, including DNA synthesis and maintenance of immunocompetence, yet very little information exists on B6 nutritional status in childhood leukemia. Using a radioenzymatic assay, the authors measured plasma pyridoxal 5'-phosphate (PLP), the biologically active form of B6, in 11 newly diagnosed untreated children with leukemia and 11 age-matched controls. The children with leukemia had significantly lower PLP levels than the controls. In 26 additional leukemia patients and 26 additional controls, a high-performance liquid chromatography assay also demonstrated lower plasma PLP levels in childhood leukemia compared with controls. These differences were significant for both acute lymphoblastic leukemia (ALL) and for acute nonlymphoblastic leukemia (ANLL). The PLP values did not correlate with indices of leukemia cell burden, but did correlate with reported B6 intake, suggesting that illness-related diet changes are at least partially responsible for the low PLP levels. Before any chemotherapy, overall nutritional status was suboptimal in 53% of ALL cases and 57% of ANLL cases. Newly diagnosed children with leukemia have suboptimal overall nutrition as well as suboptimal vitamin B6 status.

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Section: Discussionmentioning

confidence: 99%