Vitamin C and corticosteroids in viral pneumonia: a prospective cohort study

Anstey, Matthew; Lu, Jacky; Myers, Erina; Palmer, Robert H.; Wibrow, Bradley; Ho, Kwok M.

doi:10.21203/rs.3.rs-70082/v1

Cited by 1 publication

(1 citation statement)

References 7 publications

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“…Considering that various drugs used for treating COVID-19 interact with vitamin C, taking corticosteroids together with vitamin C could improve oxygenation in patients with viral pneumonia treated in the ICU. However, it was also stated that those findings should be confirmed by larger studies [ 159 ]. It was stated that oseltamivir may also be used together with vitamin C in the treatment of individuals diagnosed with COVID-19 in the future due to its potential effects [ 160 ].…”

Section: Covid-19 Treatmentmentioning

confidence: 97%

Emergent Drug and Nutrition Interactions in COVID-19: A Comprehensive Narrative Review

et al. 2021

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Coronaviruses are a large family of viruses that are known to cause respiratory tract infections ranging from colds to more severe diseases, such as Middle East Respiratory Syndrome (MERS) and the Severe Acute Respiratory Syndrome (SARS). New Coronavirus Disease 2019 (COVID-19), which led to deaths as well as social and economic disruptions, is an ongoing worldwide pandemic caused by Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2). Currently, there is no approved treatment for COVID-19. Hence, only supportive care has been approved by the World Health Organization (WHO) for now. Pharmacological agents used for the adjunctive treatment of COVID-19 following the current literature and clinical experiences include antiviral, anti-inflammatory, and anti-malaria drugs, and other traditional or untraditional treatments. However, it has been reported that the use of these drugs may have some negative effects and comorbidities. Moreover, the current data have indicated that the risk of drug-drug interactions may also be high in polypharmacy cases, especially in elderly people, some comorbidity situations, and intensive care unit (ICU) patients. It is highly possible that these situations can not only increase the risk of drug-drug interactions but also increase the risk of food/nutrition-drug interactions and affect the nutritional status. However, this issue has not yet been entirely discussed in the literature. In this review, current information on the possible mechanisms as well as pharmacokinetic and pharmacodynamic effects of some pharmacological agents used in the treatment of COVID-19 and/or their secondary interactions with nutrition were evaluated and some future directions were given.

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Section: Covid-19 Treatmentmentioning

confidence: 97%