Vitamin C and COVID-19 treatment: A systematic review and meta-analysis of randomized controlled trials

Rawat, Dimple; Roy, Avishek; Maitra, Souvik; Gulati, Ashima; Khanna, Puneet; Baidya, Dalim Kumar

doi:10.1016/j.dsx.2021.102324

Cited by 67 publications

(59 citation statements)

References 42 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…This could be explained by the fact that a deficiency of a certain vitamin may not necessarily indicate a disease process, rather it might be an outcome. In addition, the administration of vitamins after diagnosis of SARS-CoV-2 infection may not be as effective as a physiological replenished state before the diagnosis [ 62 , 63 ].…”

Section: Discussionmentioning

confidence: 99%

Dietary supplements intake during the second wave of COVID-19 pandemic: A multinational Middle Eastern study

Mukattash

Alkhalidy

Alzu'bi

et al. 2022

European Journal of Integrative Medicine

View full text Add to dashboard Cite

Introduction Despite the controversy about the benefits of dietary supplements in treating or preventing COVID-19, their use has increased worldwide even with the introduction of relevant vaccines. Thus, this study aimed to investigate the perception of Middle Eastern Arab publics of dietary supplements as prophylactic or therapeutic agents against COVID-19, and their consumption during the second wave of COVID-19 pandemic. Methods A validated, pilot tested online survey was distributed through social networking platforms in Lebanon, the Kingdom of Saudi Arabia, Palestine, Jordan, and the United Arab Emirates. Responses underwent various statistical analyses. Results A total of 2,100 responses were included. Around 44% of participants reported changes in their dietary behavior during COVID-19, and 70% believed that healthy habits may prevent the infection. Moreover, 21% believed that dietary supplements surely protect against COVID-19 and 45% thought they aid in treating it. Users of supplements during the second wave of the pandemic counted for 47%, who declared they were influenced by the media, healthcare providers, or close people. The most used supplements included Vitamins C and D and zinc. Only 34% of participants were reading supplement leaflets. The use of supplements was significantly correlated with females and exercisers, as revealed by the odds ratio and logistic regression analysis. Conclusions In line with other areas of the world, the use of dietary supplements in the Middle East against COVID-19 is not evidence-based. Competent health authorities should play their role in spreading sound awareness among the public regarding this issue.

show abstract

Section: Discussionmentioning

confidence: 99%

Dietary supplements intake during the second wave of COVID-19 pandemic: A multinational Middle Eastern study

Mukattash

Alkhalidy

Alzu'bi

et al. 2022

European Journal of Integrative Medicine

View full text Add to dashboard Cite

show abstract

“…A case series study demonstrated that in a sample of 17 patients with COVID-19 infection, there was a significant decrease in inflammatory markers, including ferritin and D-dimer, and a trend toward decreased FiO 2 requirements, after vitamin C administration [49]. Intravenous vitamin C has been studied in patients with COVID-19 and mild beneficial effects; however, to date, evidence supporting the use of vitamin C for the prophylaxis or treatment of COVID-19 has shown mixed results [50].…”

Section: Vitamin C and Coronavirus Disease 2019 (Covid-19) Infectionmentioning

confidence: 99%

“…Plasma detection of vitamin C in patients with sepsis and/ or COVID-19 infection may be important, however there may be practical difficulties in measurement. Several clinical trials have examined the effects of intravenous vitamin C in critically ill patients, however the results are inconsistent [50]. One possible explanation is the heterogeneity of the study designs and the patients included.…”

Section: Measuring Plasma Levels Of Vitamin C In Critically Ill Patientsmentioning

confidence: 99%

RETRACTED ARTICLE: The Role of Vitamin C in the Treatment of Sepsis

Vitiello

Porta

Ferrara³

2022

Drugs Ther Perspect

View full text Add to dashboard Cite

Severe viral or bacterial infections can lead to sepsis and multiorgan dysfunction, and these latter events can even cause death. Multiple lines of evidence in the literature associate vitamin C with antioxidant, anti-inflammatory, anticoagulant and immunomodulatory actions. All of these biological effects make vitamin C a potential treatment for the prevention and treatment of sepsis. In this article, we briefly summarize the data supporting the use of vitamin C as a treatment for sepsis and severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. SARS-CoV-2 is responsible for the current ongoing coronavirus disease 2019 (COVID-19) pandemic.

show abstract

“…Several studies have examined the effect of vitamin C treatment in patients with COVID-19 10 , 11 , 12 , 13 , 15 , 16 , 17 , 18 ; however, the reported results varied, and recent meta-analyses reported no treatment effects. 19 , 20 Therefore, there is no strong evidence regarding the effect of vitamin C on COVID-19.…”

Section: Introductionmentioning

confidence: 99%

YouTube as a source of information regarding the effect of vitamin C on coronavirus disease

Lee

Chang

2022

Complementary Therapies in Medicine

View full text Add to dashboard Cite

Vitamin C and COVID-19 treatment: A systematic review and meta-analysis of randomized controlled trials

Cited by 67 publications

References 42 publications

Dietary supplements intake during the second wave of COVID-19 pandemic: A multinational Middle Eastern study

Dietary supplements intake during the second wave of COVID-19 pandemic: A multinational Middle Eastern study

RETRACTED ARTICLE: The Role of Vitamin C in the Treatment of Sepsis

YouTube as a source of information regarding the effect of vitamin C on coronavirus disease

Contact Info

Product

Resources

About