Vitamin C and Flavonoids Potentiate CFTR Cl Transport in Human Airway Epithelia

Fischer, Horst; Illek, Beate

doi:10.1007/0-387-23250-8_10

Cited by 2 publications

(2 citation statements)

References 42 publications

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“…L-ascorbate is a metabolically active component of the nasal and tracheobronchial airway lining fluids and appears to serve as an important biological effector of CFTR-mediated chloride secretion. (1–4) Altered ion transport, and hence disrupted mucociliary function, could play a role in the pathogenesis of sinus disease. (5)…”

Section: Introductionmentioning

confidence: 99%

“…l-Ascorbate is a metabolically active component of the nasal and tracheobronchial airway lining fluids and appears to serve as an important biological effector of CFTR-mediated chloride secretion. [1][2][3][4] Altered ion transport and, hence, disrupted mucociliary function, could play a role in the pathogenesis of sinus disease. 5 A prospective trial showed that serum vitamin C (l-ascorbate) levels are lower in chronic sinusitis patients compared with controls, and a recent study showed that l-ascorbate is depleted in the fluid lining the respiratory tract as a consequence of oxidative stress.…”

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Effect of L-Ascorbate on Chloride Transport in Freshly Excised Sinonasal Epithelia

Cho

Hwang

Illek³

2009

Am J Rhinol�Allergy

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Background Chronic rhinosinusitis (CRS) occurs at high frequency in patients with cystic fibrosis, suggesting that the cystic fibrosis transmembrane conductance regulator (CFTR) chloride (Cl) ion channel might be involved in the development of chronic sinusitis in the general population. CFTR Cl ion transport controls the hydration of mucosal surfaces and promotes effective mucociliary clearance. Altered ion transport, and hence disrupted mucociliary function, could play a role in the pathogenesis of sinus disease. L-ascorbate is a metabolically active component of the nasal and tracheobronchial airway lining fluids and appears to serve as an important biological effector of CFTR-mediated chloride secretion. The purpose of this study was to determine the effects of L-ascorbate on Cl ion transport in freshly excised sinonasal epithelia from normal controls and patients with CRS. Methods Four different types of sinonasal tissue (normal sinus mucosa, sinus mucosa from CRS, normal nasal mucosa, nasal mucosa from CRS) were obtained during endoscopic sinus surgery and mounted on sliders with open areas of 0.03 to 0.71cm2 between Ussing hemichambers. Short-circuit current (Isc) was continuously recorded, and a serosa-to-mucosa-directed Cl gradient was applied to increase the electrochemical driving force. Results L-ascorbate (500µM) stimulated Cl currents (ΔICl, µA/cm2) across sinonasal epithelia from normal and CRS patients. The Cl secretory response to L-ascorbate was effectively blocked by the Cl ion transport inhibitors glibenclamide and bumetanide. A maximal dose of L-ascorbate (at 1 mM) stimulated 53–70% of Cl currents elicited by the cAMP agonist forskolin. CRS sinonasal tissue was characterized by impaired Cl secretory responses to L-ascorbate that were reduced by 33% in sinus epithelial tissue and by 70% in nasal epithelial tissue when compared to normal subjects. In nasal epithelial tissue from normal subjects, Cl secretion was approximately 2-fold increased when compared to sinus epithelial tissue. In contrast, nasal versus sinus epithelial tissue from CRS patients showed no differences. Conclusion Topical administration of L-ascorbate to freshly excised sinus and nasal mucosa enhances chloride secretion. Given that decreased CFTR-mediated Cl secretion may contribute to the development of CRS, L-ascorbate may offer potential as a therapeutic agent for the improvement of mucociliary clearance.

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confidence: 99%

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confidence: 99%

Effect of L-Ascorbate on Chloride Transport in Freshly Excised Sinonasal Epithelia

Cho

Hwang

Illek³

2009

Am J Rhinol�Allergy

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Therapeutic Effects of Vitamins and Nutritional Supplements on Sinusitis: A Narrative Review

Poudineh,

Nikzad,

Parvin

et al. 2024

Nutr Metab Insights

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Sinusitis, one of the most prevalent and undertreated disorders, is a term used to describe inflammation of the paranasal sinuses caused by either infectious or non-infectious sources. Bacterial, viral, or fungal infections can all cause sinusitis. Sinusitis is classified into 3 types: acute, subacute, and chronic. Acute sinusitis lasts for less than 1 month, subacute sinusitis lasts from 1 to 3 months, and chronic sinusitis persists for over 3 months. This condition affects a significant portion of the population, imposing a substantial burden on the healthcare system. Antibiotics are the gold standard of bacterial sinusitis treatment. However, due to the rise of antimicrobial resistance, especially in immune-compromised patients, it is necessary to investigate potential adjunctive therapies. Based on the literature, vitamins (eg, vitamin D) have antioxidant, anti-inflammatory, and immune-modulatory properties and may effectively treat sinusitis and reduce mucous membrane inflammation. Besides vitamins, many other supplements like quercetin, sinupret, and echinacea have immunomodulatory effects and have shown promising results in sinusitis treatment. In this review, we look at the therapeutic role, safety, and efficacy of vitamins and nutritional supplements in sinusitis treatment.

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Vitamin C and Flavonoids Potentiate CFTR Cl Transport in Human Airway Epithelia

Cited by 2 publications

References 42 publications

Effect of L-Ascorbate on Chloride Transport in Freshly Excised Sinonasal Epithelia

Effect of L-Ascorbate on Chloride Transport in Freshly Excised Sinonasal Epithelia

Therapeutic Effects of Vitamins and Nutritional Supplements on Sinusitis: A Narrative Review

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