Vitamin C Deficiency Attenuates Liver Fibrosis by Way of Up-Regulated Peroxisome Proliferator-Activated Receptor-Gamma Expression in Senescence Marker Protein 30 Knockout Mice

Park, Jin‐Kyu; Ki, Mi-Ran; Lee, Hye-Rim; Hong, Il-Hwa; Ji, Ae-Ri; Ishigami, Akihito; Park, Se-Il; Kim, Jimin; Chung, Habong; Yoo, Sung‐Eun; Jeong, Kyu‐Shik

doi:10.1002/hep.23499

Cited by 57 publications

(36 citation statements)

References 50 publications

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“…Ascorbate supplementation slightly reduced CCl 4 -induced liver fibrosis in WT mice; in contrast, it accelerated liver fibrosis in CCl 4 -intoxicated SMP30 −/− mice that was less severe than in WT mice, as shown in our previous work [9]. Dietary ascorbate consumption decreases oxidative stress and the inflammatory status for healthy humans [31], as shown in the results from the CCl 4 -injured WT mice.…”

Section: Discussionmentioning

confidence: 68%

“…Sixteen weeks after a CCl 4 injection every other day, WT mice showed signs of hepatic fibrosis, whereas SMP30 −/− mice had a significant attenuation in fibrosis so much as about 60% of that of WT mice, as demonstrated in previous data [9]. The serum ALT levels reflects the severity of liver damage and is widely viewed as a specific indicator of liver necrosis [16].…”

Section: Ascorbate Increases Serum Alt and Tnf-α Levels Inccl 4 -Intomentioning

confidence: 83%

“…The apparent liver damage of SMP30 deficient mice, however, was less severe than that of WT mice. Recently, our study demonstrated that the up-regulation of peroxisome proliferators-activated receptor-gamma (PPAR-γ) caused by a lack of ascorbate was the pivotal factor in the mechanisms for attenuated liver fibrosis of SMP30 −/− mice [9]. PPAR-γ is an important negative regulator not only of hepatic stellate cells activation [10], but also of inflammation [11].…”

Section: Introductionmentioning

confidence: 97%

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Ascorbate promotes carbon tetrachloride-induced hepatic injury in senescence marker protein 30-deficient mice by enhancing inflammation

Lee

Park

et al. 2011

The Journal of Nutritional Biochemistry

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Section: Discussionmentioning

confidence: 68%

Section: Ascorbate Increases Serum Alt and Tnf-α Levels Inccl 4 -Intomentioning

confidence: 83%

Section: Introductionmentioning

confidence: 97%

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Ascorbate promotes carbon tetrachloride-induced hepatic injury in senescence marker protein 30-deficient mice by enhancing inflammation

Lee

Park

et al. 2011

The Journal of Nutritional Biochemistry

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“…At the stage of stress condition induced by carbon tetrachloride treatment, hepatic stellate cells, which are responsible for making connective tissues that leads to fibrosis and further fatal organ dysfunction, got contain lipid accumulation. Simultaneously, upregulation of peroxisome-proliferator-activated receptor γ was identified in protein levels, indicating the involvement of adipogenesis [22]. So here it can be assumed to have a strong involvement of peroxisome-proliferator-activated receptor γ for lipid accumulation on diverse organs such as the liver and muscles.…”

Section: Discussionmentioning

confidence: 80%

Dystrophin Degradation in Skeletal Muscles with Lipid Enrichment in Cattle

Jeon¹,

Kim

Lee³

et al. 2016

Journal of Life Science

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This study investigated the muscular dystrophin levels in freely moving Australian cattle mainly fed grass, freely moving Korean cattle fed mainly a grain diet, and Korean cattle fed a grain diet but housed in a relatively limited space of a cow house. The total skeletal muscle specimens of 244 cattle were collected and immediately fixed in 10% neutral formalin. The same area was biopsied from the cattle in both countries. The findings showed that fatty infiltration is highly correlated with membrane-associated protein degradation in skeletal muscle, and that among several membrane-associated proteins, dystrophin showed the most significant reduction in expression in the cattle with fatty infiltration. Similarly, CD36 was more highly expressed in the cattle with fatty infiltration of skeletal muscle. Various breeding factors, such as oxidative stress; the presence of oxidized lipids in the diet; and environmental factors such as exercise, temperature and amount of time spent, may have critical effects on the degradation of normal cytoskeleton proteins, which are required for maintaining normal skeletal muscle architecture. Among the sarcolemma membrane-associated proteins, dystrophin is the most sensitive membrane protein that is involved muscular dystrophy and muscular degeneration. Thus, the present findings may be useful for studies on muscular dystrophy in humans or the pathogenesis of muscular diseases in animal models.

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“…On the other hand, in Asian countries, the donation from deceased donors is severely limited because of various cultural and social reasons [16]. Approximately 50% of patients listed for emergency liver transplantation have died while awaiting a graft because of the lack of a timely suitable donor [17,18]. So, in order to rescue more patients in a setting of the shortage of liver grafts, prognostic factors useful to determine the suitable timing for liver transplantation are required.…”

Section: Discussionmentioning

confidence: 99%

Serum Levels of Soluble Adhesion Molecules as Prognostic Factors for Acute Liver Failure

et al. 2012

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Background/Aims: In patients with septic shock, the degree of liver dysfunction is correlated with serum levels of soluble intercellular adhesion molecule (sICAM)-1. We aimed to assess the usefulness of serum levels of soluble adhesion molecules as prognostic factors for acute liver failure (ALF). Methods: Serum levels of soluble platelet endothelial cell adhesion molecule (sPECAM)-1, sICAM-3, soluble endothelial (sE) selectin, sICAM-1, soluble platelet selectin, and soluble vascular cell adhesion molecule-1 on admission were measured in 37 ALF patients and 34 healthy controls. Results: Twenty-two ALF patients (59%) reached to fatal outcomes. Serum levels of sPECAM-1, sICAM-3, sE-selectin and sICAM-1 were higher in ALF patients than healthy controls. In 37 ALF patients, by the multivariate logistic regression analysis, ratio of direct to total bilirubin (per 0.1 increase; OR 0.11, 95% CI 0.01–0.99), serum sPECAM-1 level (per 100 ng/ml increase; OR 4.37, 95% CI 1.23–15.5) and serum sICAM-1 level (per 100 ng/ml increase; OR 0.49, 95% CI 0.27–0.89) were associated with fatal outcomes. Using receiver operating characteristics curve, each area under the curve of serum sPECAM-1 and sICMA-1 levels as prognostic factors was 0.71 and 0.74, respectively. Conclusion: Serum sPECAM-1 and sICAM-1 levels may be useful for predicting the prognosis of ALF.

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Vitamin C Deficiency Attenuates Liver Fibrosis by Way of Up-Regulated Peroxisome Proliferator-Activated Receptor-Gamma Expression in Senescence Marker Protein 30 Knockout Mice

Cited by 57 publications

References 50 publications

Ascorbate promotes carbon tetrachloride-induced hepatic injury in senescence marker protein 30-deficient mice by enhancing inflammation

Ascorbate promotes carbon tetrachloride-induced hepatic injury in senescence marker protein 30-deficient mice by enhancing inflammation

Dystrophin Degradation in Skeletal Muscles with Lipid Enrichment in Cattle

Serum Levels of Soluble Adhesion Molecules as Prognostic Factors for Acute Liver Failure

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