Vitamin C in der Behandlung der kruppösen Pneumonie

Hochwald, Adolf

doi:10.1055/s-0028-1120960

Cited by 18 publications

(3 citation statements)

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“…Before vitamin C was identified, scurvy was associated with an elevated risk of pneumonia [2,48], which suggests that vitamin C might have clinically relevant effects on infections. After the isolation of vitamin C, a few German and US physicians proposed that it might be beneficial in the treatment of pneumonia [191,192,193,194,195,196,197]. However, to our knowledge, only two small controlled trials published decades ago have investigated the effect of vitamin C for treating pneumonia.…”

Section: Discussionmentioning

confidence: 99%

“…However, with the early understanding of biochemistry it was not evident how vitamin C could have an effect on infections, cancer, or other diseases that did not involve collagen metabolism. Thus, it seems that the limited biochemical understanding may have been one reason why the early findings [2,186,187,188,189,190,191,192,193,194,195,196,197,198,199,244] were not pursued.…”

Section: Discussionmentioning

confidence: 99%

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Vitamin C Can Shorten the Length of Stay in the ICU: A Meta-Analysis

2019

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A number of controlled trials have previously found that in some contexts, vitamin C can have beneficial effects on blood pressure, infections, bronchoconstriction, atrial fibrillation, and acute kidney injury. However, the practical significance of these effects is not clear. The purpose of this meta-analysis was to evaluate whether vitamin C has an effect on the practical outcomes: length of stay in the intensive care unit (ICU) and duration of mechanical ventilation. We identified 18 relevant controlled trials with a total of 2004 patients, 13 of which investigated patients undergoing elective cardiac surgery. We carried out the meta-analysis using the inverse variance, fixed effect options, using the ratio of means scale. In 12 trials with 1766 patients, vitamin C reduced the length of ICU stay on average by 7.8% (95% CI: 4.2% to 11.2%; p = 0.00003). In six trials, orally administered vitamin C in doses of 1–3 g/day (weighted mean 2.0 g/day) reduced the length of ICU stay by 8.6% (p = 0.003). In three trials in which patients needed mechanical ventilation for over 24 hours, vitamin C shortened the duration of mechanical ventilation by 18.2% (95% CI 7.7% to 27%; p = 0.001). Given the insignificant cost of vitamin C, even an 8% reduction in ICU stay is worth exploring. The effects of vitamin C on ICU patients should be investigated in more detail.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Vitamin C Can Shorten the Length of Stay in the ICU: A Meta-Analysis

2019

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“…Vitamin C was purified in the early 1930s and soon thereafter a few German and U.S. physicians proposed that vitamin C might be beneficial in the treatment of pneumonia. For example, Gander and Niederberger (1936) concluded from a series of 15 cases that “the general condition is always favorably influenced (by vitamin C) to a noticeable extent, as is the convalescence, which proceeds better and more quickly than in cases of pneumonia, which are not treated with vitamin C” [114] and other German physicians also claimed benefits of vitamin C [115,116]. Translations of these papers are available [9].…”

Section: Pneumoniamentioning

confidence: 99%

Vitamin C and Infections

2017

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In the early literature, vitamin C deficiency was associated with pneumonia. After its identification, a number of studies investigated the effects of vitamin C on diverse infections. A total of 148 animal studies indicated that vitamin C may alleviate or prevent infections caused by bacteria, viruses, and protozoa. The most extensively studied human infection is the common cold. Vitamin C administration does not decrease the average incidence of colds in the general population, yet it halved the number of colds in physically active people. Regularly administered vitamin C has shortened the duration of colds, indicating a biological effect. However, the role of vitamin C in common cold treatment is unclear. Two controlled trials found a statistically significant dose–response, for the duration of common cold symptoms, with up to 6–8 g/day of vitamin C. Thus, the negative findings of some therapeutic common cold studies might be explained by the low doses of 3–4 g/day of vitamin C. Three controlled trials found that vitamin C prevented pneumonia. Two controlled trials found a treatment benefit of vitamin C for pneumonia patients. One controlled trial reported treatment benefits for tetanus patients. The effects of vitamin C against infections should be investigated further.

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Vitamin C for preventing and treating pneumonia

Hemilä¹,

Louhiala²

2007

Cochrane Database of Systematic Reviews

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Vitamin C in der Behandlung der kruppösen Pneumonie

Cited by 18 publications

References 0 publications

Vitamin C Can Shorten the Length of Stay in the ICU: A Meta-Analysis

Vitamin C Can Shorten the Length of Stay in the ICU: A Meta-Analysis

Vitamin C and Infections

Vitamin C for preventing and treating pneumonia

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