2018
DOI: 10.5492/wjccm.v7.i5.52
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Vitamin C in the critically ill - indications and controversies

Abstract: Ascorbic acid (vitamin C) elicits pleiotropic effects in the body. Among its functions, it serves as a potent anti-oxidant, a co-factor in collagen and catecholamine synthesis, and a modulator of immune cell biology. Furthermore, an increasing body of evidence suggests that high-dose vitamin C administration improves hemodynamics, end-organ function, and may improve survival in critically ill patients. This article reviews studies that evaluate vitamin C in pre-clinical models and clinical trials with respect … Show more

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Cited by 44 publications
(39 citation statements)
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“…Generally, the extract demonstrated better therapeutic potential as well as better preservation of pituitary and testicular histoarchitecture when compared with the standard treatment group (co‐administration of vitamin C). This suggests that the therapeutic dose of vitamin C (50 mg/kg) adopted for research purposes may not be adequate in the management of subjects with cimetidine‐induced reproductive toxicity. As a result of our study, we recommend either a review of this therapeutic dose or that it is used as an adjunct to other interventions in the management or treatment of cimetidine‐induced reproductive toxicity.…”
Section: Discussionmentioning
confidence: 99%
“…Generally, the extract demonstrated better therapeutic potential as well as better preservation of pituitary and testicular histoarchitecture when compared with the standard treatment group (co‐administration of vitamin C). This suggests that the therapeutic dose of vitamin C (50 mg/kg) adopted for research purposes may not be adequate in the management of subjects with cimetidine‐induced reproductive toxicity. As a result of our study, we recommend either a review of this therapeutic dose or that it is used as an adjunct to other interventions in the management or treatment of cimetidine‐induced reproductive toxicity.…”
Section: Discussionmentioning
confidence: 99%
“…Ascorbic acid is a key compound of the antioxidant system in cells and tissues [123]. The biological and medicinal properties of Vit-C in critical care management are documented [124]. It is now accepted that both viral and bacterial infections result in the production of excess cytokine [118].…”
Section: Treatment Of Viral Infectionsmentioning
confidence: 99%
“…Doses higher than 2 g/day can cause diarrhoea, abdominal pain and nausea, which are self-limited once the dose is reduced [ 99 , 100 ]. There is a concern that high dose of vitamin C (10 g/day) could lead to a supraphysiological level of vitamin C which causes oxaluria and increases the risk of oxalate nephropathy and oxalate kidney stone [ 101 , 102 ]. In a randomised, crossover, controlled study, vitamin C supplement of 1000 mg twice a day increased urinary oxalate in 40% of the participants, which in turn increases the risk of oxalate kidney stone [ 103 ].…”
Section: The Safety Profile Of Vitamin Cmentioning
confidence: 99%