2016
DOI: 10.1159/000447848
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Vitamin C Inhibits Aggravated Eryptosis by Hydrogen Peroxide in Glucose-6-Phosphated Dehydrogenase Deficiency

Abstract: Background/Aims: The study was aimed to investigate if vitamin C could exert protective effects on development of eryptosis caused by glucose-6-phosphate dehydrogenase (G6PD) deficiency and hydrogen peroxide. Methods: Isolated erythrocytes with different G6PD activity (normal or deficient) were divided into various groups treated by either Vitamin C or H2O2. Phosphatidylserine (PS) extroversion rate was detected by Annexin V binding. The intracellular Ca2+ concentration was det… Show more

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Cited by 38 publications
(26 citation statements)
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“…The effect is at least partially due to increase C-reactive protein, which increases cytosolic Ca 2+ activity and ceramide formation in erythrocytes. As several inhibitors of eryptosis are available [2-4, 93, 94], eryptosis and subsequent development of anemia may be prevented.…”
Section: Discussionmentioning
confidence: 99%
“…The effect is at least partially due to increase C-reactive protein, which increases cytosolic Ca 2+ activity and ceramide formation in erythrocytes. As several inhibitors of eryptosis are available [2-4, 93, 94], eryptosis and subsequent development of anemia may be prevented.…”
Section: Discussionmentioning
confidence: 99%
“…Vitamin C and NAC have already been shown to inhibit eryptosis in vitro . Besides, vitamin C inhibits eryptosis in glucose‐6‐phosphate‐dehydrogenase deficiency .…”
Section: Pharmacological Inhibition Of Oxidative Stress In Erythrocytmentioning
confidence: 97%
“…To the extent that stimulated eryptosis may lead to anemia and thrombosis, it may be desirable to inhibit eryptosis. As a matter of fact, a wide variety of compounds such as blebbistatin, phlorhizin, vitamin C, resveratrol, reversine, hydroxytyrosol, volasertib, ASP3026 and teriflunomide have previously been shown to inhibit eryptosis in vitro . Some of these substances have previously been shown to counteract oxidative stress and may potentially be effective in vivo and could, therefore, be considered for the treatment of eryptosis‐induced anemia in different clinical conditions.…”
Section: Pharmacological Inhibition Of Oxidative Stress In Erythrocytmentioning
confidence: 99%
“…The adherence of eryptotic cells to vascular wall endothelial CXCL16/SR-PSO [61] and the binding of phosphatidylserine-exposing erythrocytes to blood platelets could further stimulate blood clotting and trigger thrombosis [62]. Eryptosis could also be induced by a wide range of xenobiotics [63-74], and enhanced eryptosis is observed in several clinical conditions, such as systemic lupus erythematosus [75], uremia under hemodialysis or peritoneal dialysis [76], pulmonary tumor [77], Parkinson’s disease [78], arteritis [79], hepatic failure [80, 81], tumor-induced anemia [82], vitamin D excess [83], advanced age [84], G6PD deficiency [85], sepsis [86], APC gene mutation and colon carcinoma [87]. Eryptosis can also be triggered by erythrocyte storage [88-90].…”
Section: Discussionmentioning
confidence: 99%