Vitamin C intake in relation to bone mineral density and risk of hip fracture and osteoporosis: a systematic review and meta-analysis of observational studies

Malmir, Hanieh; Shab‐Bidar, Sakineh; Djafarian, Kurosh

doi:10.1017/s0007114518000430

Cited by 65 publications

(61 citation statements)

References 68 publications

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“…Finally, our pooled-effects analysis revealed a negative correlation between DIVCF and risk of hip fracture (RR, 0.66; 95% CI, 0.47-0.94); i.e., subjects with a higher intake of Vitamin Coriented foods had a 34% (95% CI, 6%−53%) lower risk of hip fracture (Figure 2). Our results differ from those of Dr. Malmir, published in April 2018 (27). Due to the major heterogeneity among the studies, we performed subgroup analyses based on study type (i.e., cohort and case-control studies), gender, and age (middle-aged subjects, older subjects).…”

Section: Comparison Of the Findings With Other Results In The Literaturecontrasting

confidence: 85%

“…In this paper, we carried out a meta-analysis of the possible protective effect of DIVCF against osteoporosis, fracture, and BMD loss. A similar article (27) was published in April 2018. The authors found no significant association between Vitamin C intake and the risk of hip fracture (RR, 0.74; 95% CI, 0.51-1.08).…”

Section: Comparison Of the Findings With Other Results In The Literaturementioning

confidence: 80%

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Can Dietary Intake of Vitamin C-Oriented Foods Reduce the Risk of Osteoporosis, Fracture, and BMD Loss? Systematic Review With Meta-Analyses of Recent Studies

et al. 2020

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Background: Several epidemiological studies have been performed to evaluate the association of dietary intake of vitamin C-oriented foods (DIVCF) with risk of fracture and bone mineral density (BMD) loss, but the results remain controversial. Therefore, we conducted a systematic meta-analysis to assess this correlation. Methods: We searched EmBase, PubMed, Web of Science, and the Chinese database CNKI for relevant articles published up to August 2019. Pooled relative risks (RRs) with 95% confidence intervals (CIs) were calculated using the random-or fixed-effects model. Discrepancies were resolved by consultation with a third expert. Results: A total of 13 eligible articles (including 17 studies) with 19,484 subjects were identified for the present meta-analysis. The pooled RR of hip fracture for the highest vs. lowest category was 0.66 (95% CI, 0.47-0.94) for DIVCF, i.e., people with a greater frequency of Vitamin C uptake had a 34% (95% CI, 6%−53%) lower prevalence of hip fracture. In subgroup analyses stratified by study design, gender, and age, the negative associations were statistically significant. Furthermore, the statistical analysis of the association between DIVCF and risk of osteoporosis (RR, 0.66; 95% CI, 0.48-0.92), BMD at the lumbar spine (pooled r, 0.15; 95% CI, 0.09-0.23), and BMD at the femoral neck (pooled r, 0.20; 95% CI, 0.11-0.34) showed beneficial effects of DIVCF. Conclusion: Our meta-analysis indicates that DIVCF is negatively associated with the risk of hip fracture, osteoporosis, and BMD loss, suggesting that DIVCF decreases the risk of hip fracture, osteoporosis, and BMD loss.

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Section: Comparison Of the Findings With Other Results In The Literaturecontrasting

confidence: 85%

Section: Comparison Of the Findings With Other Results In The Literaturementioning

confidence: 80%

Can Dietary Intake of Vitamin C-Oriented Foods Reduce the Risk of Osteoporosis, Fracture, and BMD Loss? Systematic Review With Meta-Analyses of Recent Studies

et al. 2020

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“…Ascorbic acid is known to stimulate collagen synthesis and secretion (16,27), enhance healing of fractured bones in preclinical studies (30), and significantly decrease the risk of osteoporosis and hip fracture in adults (31,32). Because mice differ from humans and fish by being able to synthesize de novo vitamin C, supplementation did increase bone mass but not in a statistically significant fashion.…”

Section: Discussionmentioning

confidence: 99%

COPB2haploinsufficiency causes a coatopathy with osteoporosis and developmental delay

Marom¹,

Burrage²,

Clément³

et al. 2020

Preprint

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Coatomer complexes function in the sorting and trafficking of proteins between subcellular organelles. Pathogenic variants in coatomer subunits or associated factors have been reported in multi-systemic disorders, i.e., coatopathies, that can affect the skeletal and central nervous systems. We have identified loss-of-function variants in COPB2, a component of the coatomer complex I (COPI), in individuals presenting with osteoporosis, fractures and developmental delay of variable severity. Because the role of COPB2 in bone has not been characterized, we studied the effect of COPB2 deficiency on skeletal development in mice and zebrafish. Copb2+/− mice showed low bone mass and decreased bone strength. In zebrafish, larvae carrying a copb2 heterozygous frameshift variant showed delayed mineralization. copb2-null embryos showed endoplasmic reticulum (ER) and Golgi disorganization, and embryonic lethality. COPB2 siRNA-treated fibroblasts showed delayed collagen trafficking with retention of type I collagen in the ER and Golgi, and altered distribution of Golgi markers. Our data suggest that COPB2 haploinsufficiency leads to disruption of intracellular collagen trafficking and osteoporosis, which may improve with ascorbic acid supplementation. This work highlights the role of COPI complex as a critical regulator of bone mass and identifies a new form of coatopathy due to COPB2 deficiency.

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“…Vitamin C plays a critical role in the development and maintenance of bone where it increases the rates of both procollagen hydroxylation and secretion. Prior work has confirmed the importance of vitamin C in maintaining bone health by demonstrating a positive association with vitamin C intake and BMD at the femoral neck and lumbar spine along with a 33% lower risk of osteoporosis [ 24 ]. These effects may stem from the suppression of osteoclast activity and the differentiation of osteoblasts by vitamin C [ 25 , 26 ].…”

Section: Discussionmentioning

confidence: 99%

Metabolomic Associations with Serum Bone Turnover Markers

et al. 2020

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Bone is a dynamic tissue that is in a constant state of remodeling. Bone turnover markers (BTMs), procollagen type I N-terminal propeptide (P1NP) and C-terminal telopeptides of type I collagen (CTX), provide sensitive measures of bone formation and resorption, respectively. This study used ultra-high-resolution metabolomics (HRM) to determine plasma metabolic pathways and targeted metabolites related to the markers of bone resorption and formation in adults. This cross-sectional clinical study included 34 adults (19 females, mean 27.8 years), without reported illnesses, recruited from a US metropolitan area. Serum BTM levels were quantified by an ELISA. Plasma HRM utilized dual-column liquid chromatography and mass spectrometry to identify metabolites and metabolic pathways associated with BTMs. Metabolites significantly associated with P1NP (p < 0.05) were significantly enriched in pathways linked to the TCA cycle, pyruvate metabolism, and metabolism of B vitamins important for energy production (e.g., niacin, thiamin). Other nutrition-related metabolic pathways associated with P1NP were amino acid (proline, arginine, glutamate) and vitamin C metabolism, which are important for collagen formation. Metabolites associated with CTX levels (p < 0.05) were enriched within lipid and fatty acid beta-oxidation metabolic pathways, as well as fat-soluble micronutrient pathways including, vitamin D metabolism, vitamin E metabolism, and bile acid biosynthesis. P1NP and CTX were significantly related to microbiome-related metabolites (p < 0.05). Macronutrient-related pathways including lipid, carbohydrate, and amino acid metabolism, as well as several gut microbiome-derived metabolites were significantly related to BTMs. Future research should compare metabolism BTMs relationships reported here to aging and clinical populations to inform targeted therapeutic interventions.

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Vitamin C intake in relation to bone mineral density and risk of hip fracture and osteoporosis: a systematic review and meta-analysis of observational studies

Cited by 65 publications

References 68 publications

Can Dietary Intake of Vitamin C-Oriented Foods Reduce the Risk of Osteoporosis, Fracture, and BMD Loss? Systematic Review With Meta-Analyses of Recent Studies

Can Dietary Intake of Vitamin C-Oriented Foods Reduce the Risk of Osteoporosis, Fracture, and BMD Loss? Systematic Review With Meta-Analyses of Recent Studies

COPB2haploinsufficiency causes a coatopathy with osteoporosis and developmental delay

Metabolomic Associations with Serum Bone Turnover Markers

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