Vitamin C Levels in Old People and the Response to Ascorbic Acid and to the Juice of the Acerola (<i>Malpighia punicifolia L.</i>)

Bowers, Eric F.; Kubik, M. Michael

doi:10.1111/j.1742-1241.1965.tb04717.x

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1979

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Cited by 18 publications

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The influence of vitamin C on antipyrine pharmacokinetics in elderly men

Blanchard

Achari

Harrison

et al. 1984

Biopharm & Drug Disp

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The influence of vitamin C on the pharmacokinetics of antipyrine was investigated in eleven elderly men aged 65-74. Antipyrine (15 mg kg-1) was administered intravenously on three separate occasions over a 7-week period: (a) before dietary vitamin C restriction, (b) after approximately 5 weeks of dietary vitamin C restriction, and (c) after 2 weeks of vitamin C supplementation (500 mg orally twice daily). The mean plasma and leucocyte vitamin C levels (+/- S.D.) before vitamin C restriction were 1.26 +/- 0.31 mg dl-1 and 26.6 +/- 6.7 micrograms 10(-8) leucocytes, respectively. These values decreased and then increased significantly following vitamin C restriction and supplementation, respectively. The mean plasma half-life of antipyrine was 10.2 h and the mean plasma clearance was 2.561 h-1 1.73 m-2 before vitamin C restriction. No significant changes in the clearance, volume of distribution, or half-life of antipyrine occurred during the study, indicating that short-term alterations in vitamin C intake do not affect the pharmacokinetics of antipyrine in elderly males.

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