Vitamin C restores the contractile response to dobutamine and improves myocardial efficiency in patients with heart failure after anterior myocardial infarction

Shinke, Toshiro; Shite, Junya; Takaoka, Hideyuki; Hata, Katsuya; Inoue, N.; Yoshikawa, Ryohei; Matsumoto, Hidenari; Masai, Hiroyuki; Watanabe, Satoshi; Ozawa, Tohru; Otake, Hiromasa; Matsumoto, Daisuke; Hirata, Ken‐ichi; Yokoyama, Mitsuhiro

doi:10.1016/j.ahj.2007.07.005

Cited by 38 publications

(15 citation statements)

References 35 publications

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“…In further support of the effectiveness of our ascorbic acid‐dosing regimen, several other studies using comparable acute dosing have also described decreased plasma markers of oxidative stress and/or augmented physiological function (12,14,17,18). Similarly, augmented β‐AR function with comparable acute ascorbic acid administration has been reported in several separate studies (5,19,20). It is feasible that, in this study, despite decreased plasma‐oxidized LDL concentration no corresponding decreases in oxidative stress occurred in tissues that contributed directly to the TEF response and β‐AR function.…”

Section: Discussionsupporting

confidence: 75%

Influence of Ascorbic Acid on the Thermic Effect of Feeding in Overweight and Obese Adult Humans

Newsom

Paxton

Rynn

et al. 2008

Obesity

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The thermic effect of feeding (TEF: increase in energy expenditure following acute energy intake) is an important physiological determinant of total daily energy expenditure and thus energy balance. Approximately 40% of TEF is believed to be mediated by sympathoadrenal activation and consequent β-adrenergic receptor stimulation of metabolism. In sedentary adults, acute administration of ascorbic acid, a potent antioxidant, augments the thermogenic response to β-adrenergic stimulation. We hypothesized that acute ascorbic acid administration augments TEF in sedentary overweight and obese adults. Energy expenditure was determined (ventilated hood technique) before and 4 h after consumption of a liquid-mixed meal (caloric equivalent 40% of resting energy expenditure (REE)) in 11 sedentary, overweight/obese adults (5 men, 6 women; age: 24 ± 2 years; BMI: 28.5 ± 1.0 kg/m 2 (mean ± s.e.)) on two separate, randomly ordered occasions: during continuous intravenous administration of saline (placebo control) and/or ascorbic acid (0.05 g/kg fat-free mass). Acute ascorbic acid administration prevented the increase in plasma concentration of oxidized low-density lipoprotein in the postprandial state (P = 0.04), but did not influence REE (1,668 ± 107 kcal/day vs. 1,684 ± 84 kcal/day; P = 0.91) or the area under the TEF response curve (33.4 ± 2.4 kcal vs. 30.5 ± 3.6 kcal; P = 0.52) (control vs. ascorbic acid, respectively). Furthermore, acute ascorbic acid administration had no effect on respiratory exchange ratio, heart rate, or arterial blood pressure in the pre-and postabsorptive states (all P > 0.64). These data imply that the attenuated TEF commonly observed with sedentary lifestyle and obesity is not modulated by ascorbic acid-sensitive oxidative stress.

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Section: Discussionsupporting

confidence: 75%

Influence of Ascorbic Acid on the Thermic Effect of Feeding in Overweight and Obese Adult Humans

Newsom

Paxton

Rynn

et al. 2008

Obesity

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“…However, little is known about the function of ROS on beat-to-beat regulation of cardiac contractility under these pathological conditions. In agreement, Shinke et al (2007) reported that acute administration of the antioxidant vitamin C enhanced the contractile response to dobutamine and improved myocardial efficiency in patients with moderate left ventricular dysfunction. Suppression of ROS generation by xanthine oxidase inhibitor allopurinol alone leads to an improvement in resting cardiac contractile performance in dogs with chronic heart failure.…”

Section: Perspectivessupporting

confidence: 61%

“…These data reveal that ROS can acutely influence cardiac contractile performance in the failing heart in addition to their impact on cardiomyocyte growth and survival. In agreement, Shinke et al (2007) reported that acute administration of the antioxidant vitamin C enhanced the contractile response to dobutamine and improved myocardial efficiency in patients with moderate left ventricular dysfunction. On the contrary, the positive effect of vitamin C on dobutamine-induced inotropic response was not observed in patients with more severe systolic heart failure (Mak & Newton 2004).…”

Section: Perspectivessupporting

confidence: 61%

Physiological regulation of cardiac contractility by endogenous reactive oxygen species

Perjés¹,

Kubin

Kónyi

et al. 2012

Acta Physiol

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Increased production of reactive oxygen species (ROS) has been linked to the pathogenesis of congestive heart failure. However, emerging evidence suggests the involvement of ROS in the regulation of various physiological cellular processes in the myocardium. In this review, we summarize the latest findings regarding the role of ROS in the acute regulation of cardiac contractility. We discuss ROS-dependent modulation of the inotropic responses to G protein-coupled receptor agonists (e.g. b-adrenergic receptor agonists and endothelin-1), the potential cellular sources of ROS (e.g. NAD(P)H oxidases and mitochondria) and the proposed end-targets and signalling pathways by which ROS affect contractility. Accumulating new data supports the fundamental role of endogenously generated ROS to regulate cardiac function under physiological conditions.

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“…The results of Bing and Michal (4) were confirmed by Thompson et al (51), who found a net efficiency of 39.4% in control human hearts. In patients with mild to moderate heart failure or idiopathic cardiomyopathy, efficiencies, without a correction for basal O 2 consumption, have been reported of 25-34% (6,(45)(46)(47). We therefore argue that mechanical efficiency values for normal whole hearts can be considerably higher than the commonly accepted values of 20 -25%.…”

Section: )]mentioning

confidence: 82%

Reduced mechanical efficiency of rat papillary muscle related to degree of hypertrophy of cardiomyocytes

Wong¹,

Handoko²,

Mouchaers³

et al. 2010

American Journal of Physiology-Heart and Circulatory Physiology

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Isolated rat papillary muscles of the right ventricle were used to discover the origin of reduced myocardial efficiency in chronic heart failure. Right ventricular hypertrophy was induced by monocrotaline injection, causing pulmonary hypertension. Control (n = 7) and hypertrophied (n = 11) papillary muscles were subjected to sinusoidal length changes at 37 degrees C and 5 Hz with a peak-to-peak amplitude of 15% of the length giving maximum force (L(max)) after being stretched to 92.5% of L(max). Isometric tension at L(max) was similar in control and hypertrophied muscles. Work was assessed from the area encompassed by force-length loops. Work per loop was 0.93 +/- 0.11 and 0.84 +/- 0.11 microJ/mm(3) (means +/- SE) for control and hypertrophied muscles, respectively (P = 0.591). Suprabasal O(2) uptake per work loop was 5.7 +/- 0.7 pmol/mm(3) in control muscles and 8.7 +/- 1.7 pmol/mm(3) in hypertrophied muscles (P = 0.133). Net mechanical efficiency was calculated from the ratio of work output and suprabasal O(2) uptake. The efficiency of hypertrophied muscles was 29.1 +/- 3.7% and was smaller than in control muscles (43.7 +/- 2.2%, P = 0.016). The right ventricular cardiomyocyte cross-sectional area increased from 272 +/- 17 microm(2) in control muscles to 396 +/- 31 microm(2) in hypertrophied muscles (P < 0.003). Mechanical efficiency correlated negatively with right ventricular wall thickness and cardiomyocyte cross-sectional area [Spearman rank correlation coefficients of -0.50 (P = 0.039) and -0.53 (P = 0.024), respectively]. We conclude that efficiency decreases with increasing cardiomyocyte hypertrophy. Thus, the reduced efficiency of diseased whole hearts can be at least partly explained by reduced efficiency at the cardiomyocyte level.

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Vitamin C restores the contractile response to dobutamine and improves myocardial efficiency in patients with heart failure after anterior myocardial infarction

Cited by 38 publications

References 35 publications

Influence of Ascorbic Acid on the Thermic Effect of Feeding in Overweight and Obese Adult Humans

Influence of Ascorbic Acid on the Thermic Effect of Feeding in Overweight and Obese Adult Humans

Physiological regulation of cardiac contractility by endogenous reactive oxygen species

Reduced mechanical efficiency of rat papillary muscle related to degree of hypertrophy of cardiomyocytes

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