Vitamin C supplementation and serum uric acid: A reaction to hyperuricemia and gout disease

Azzeh, Firas S.; Al-Hebshi, Abrar H.; Alessimii, Haya; Alarjah, Mohammed

doi:10.1016/j.phanu.2017.02.002

Cited by 9 publications

(9 citation statements)

References 13 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Fructose and vitamin C have opposite effects on serum UA concentrations, as vitamin C has been proven to lower the serum UA concentrations (Gao et al, 2008;Zheng et al, 2018). Studies have shown that supplementing vitamin C (500 mg/day) for two months can significantly reduce serum UA concentrations in patients with hyperuricemia (Azzeh et al, 2017).…”

Section: Vitamin Cmentioning

confidence: 99%

A review on the fruit components affecting uric acid level and their underlying mechanisms

2021

View full text Add to dashboard Cite

Uric acid (UA) is produced in the liver and excreted through the kidneys and intestines. If UA is overproduced or its excretion reduces, the concentration of UA increases, leading to hyperuricemia and gout. The high concentration of UA is also related to cardiovascular disease, hypertension, obesity, and other diseases. Fruits are healthy foods. However, fruits contain fructose and small amounts of purine, and the product of their metabolism is UA. Therefore, theoretically, eating fruits will increase the concentration of serum UA. Fruit components are numerous, and their effects on serum UA are complex. According to the current research, fructose, purine, polyphenols, vitamin C, dietary fiber, and minerals present in fruits influence serum UA concentrations. In addition to the UA synthesized by fructose and purine metabolism, the mechanisms by which other components affect the concentration of serum UA can be summarized as follows: (a) inhibiting xanthine oxidase; (b) reducing reabsorption of UA; and (c) improving the excretion of UA. In this review, we comprehensively discussed the fruit components that affect serum UA concentrations, and explained their mechanisms for the first time, which references for patients with hyperuricemia to take fruits. Practical applicationsWith the rising prevalence, hyperuricemia and gout have become public health problems that endanger our daily life. The key to the treatment of hyperuricemia is to control the level of serum UA within the normal range. Fruits are healthy foods.However, fruit components are numerous, and their effects on serum UA are complex. According to the current research, fructose, purine, polyphenols, vitamin C, dietary fiber, and minerals present in fruits influence serum UA concentrations. In this review, we comprehensively discussed the fruit components that affect serum UA concentrations. We also explained their mechanisms, which references for patients with hyperuricemia to take fruits.

show abstract

Section: Vitamin Cmentioning

confidence: 99%

A review on the fruit components affecting uric acid level and their underlying mechanisms

2021

View full text Add to dashboard Cite

show abstract

“…Five people with gout qualified for this study, but there are no detailed results for this group; the study is described above. Two other studies did not show a significant reduction in uric acid concentration in patients with gout [ 75 , 76 ] who were supplemented with vitamin C at a dose of 500 mg/day for two months but for whom stabilization of the SUA level was demonstrated. A study by Stamp et al compared the effect of supplementation with vitamin C with the addition of allopurinol therapy—modifying its current dose or adding VC to the current dose of allopurinol.…”

Section: Resultsmentioning

confidence: 95%

“…Further work focused on SUA levels in the healthy population and patients with various chronic diseases, including end-stage renal disease [ 66 , 67 , 68 , 69 , 70 , 71 , 72 , 73 , 74 ]. The last subgroup consisted of studies where patients with gout in their clinical history were included [ 44 , 75 , 76 ]. All studies were relatively short and lasted from a few hours to a maximum of three months.…”

Section: Resultsmentioning

confidence: 99%

See 1 more Smart Citation

Role of Vitamin C in Prophylaxis and Treatment of Gout—A Literature Review

et al. 2021

View full text Add to dashboard Cite

Gout, known as “the disease of the kings”, is the most frequent type of arthritis. It results from sustained hyperuricemia that leads to monosodium urate crystal deposition in joint structures and soft tissue. Environmental factors such as diet affect the incidence of gout; there is a known relationship between the occurrence of an acute attack of gout and the consumption of alcohol and meat; and a low purine diet is a widely recognized nonpharmacological method of supplementing the treatment and preventing recurrence of arthritis. This review aims to summarize the current knowledge about the role of vitamin C in prevention and treatment of gout. A PubMed/Medline database search on the role of vitamin C in purine metabolism was done. Reports from in vitro and animal studies seem to be promising and to allow explanation of the physiological relationship between vitamin C and uric acid. Most epidemiological studies indicate a significant correlation between high vitamin C intake and lower serum uric acid levels. Despite promising observations, there are few observational and interventional studies, and their results do not clearly define the benefits of a high daily intake of vitamin C in preventing the development and recurrence of gout.

show abstract

“…A second study on the effect of vitamin C was performed by Azzeh et al (2017). They investigated the effect of a daily 500-mg vitamin C supplement on SUA in subjects with hyperuricemia or gout [31]. In this study, 30 subjects were included, 15 with gout and 15 with hyperuricemia.…”

Section: Supplementsmentioning

confidence: 99%

Dietary Interventions for Gout and Effect on Cardiovascular Risk Factors: A Systematic Review

et al. 2019

View full text Add to dashboard Cite

Gout is one of the most prevalent inflammatory rheumatic disease. It is preceded by hyperuricemia and associated with an increased risk for cardiovascular disease, both related to unhealthy diets. The objective of this systematic review is to better define the most appropriate diet addressing both disease activity and traditional cardiovascular risk factors in hyperuricemic patients. We included clinical trials with patients diagnosed with hyperuricemia or gout, investigating the effect of dietary interventions on serum uric acid (SUA) levels, gout flares and—if available—cardiovascular risk factors. Eighteen articles were included, which were too heterogeneous to perform a meta-analysis. Overall, the risk of bias of the studies was moderate to high. We distinguished four groups of dietary interventions: Calorie restriction and fasting, purine-low diets, Mediterranean-style diets, and supplements. Overall, fasting resulted in an increase of SUA, whilst small (SUA change +0.3 to −2.9 mg/dL) but significant effects were found after low-calorie, purine-low, and Mediterranean-style diets. Studies investigating the effect on cardiovascular risk factors were limited and inconclusive. Since Mediterranean-style diets/DASH (Dietary Approach to Stop Hypertension) have shown to be effective for the reduction of cardiovascular risk factors in other at-risk populations, we recommend further investigation of such diets for the treatment of gout.

show abstract

Vitamin C supplementation and serum uric acid: A reaction to hyperuricemia and gout disease

Cited by 9 publications

References 13 publications

A review on the fruit components affecting uric acid level and their underlying mechanisms

A review on the fruit components affecting uric acid level and their underlying mechanisms

Role of Vitamin C in Prophylaxis and Treatment of Gout—A Literature Review

Dietary Interventions for Gout and Effect on Cardiovascular Risk Factors: A Systematic Review

Contact Info

Product

Resources

About