2016
DOI: 10.1111/odi.12446
|View full text |Cite
|
Sign up to set email alerts
|

Vitamin C: the known and the unknown and Goldilocks

Abstract: Vitamin C (Ascorbic Acid), the antiscorbutic vitamin, cannot be synthesized by humans and other primates, and has to be obtained from diet. Ascorbic acid is an electron donor and acts as a cofactor for fifteen mammalian enzymes. Two sodium-dependent transporters are specific for ascorbic acid, and its oxidation product dehydroascorbic acid is transported by glucose transporters. Ascorbic acid is differentially accumulated by most tissues and body fluids. Plasma and tissue vitamin C concentrations are dependent… Show more

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
2
1
1

Citation Types

5
557
1
22

Year Published

2016
2016
2024
2024

Publication Types

Select...
5
4

Relationship

0
9

Authors

Journals

citations
Cited by 578 publications
(585 citation statements)
references
References 322 publications
(526 reference statements)
5
557
1
22
Order By: Relevance
“…vitamin C, in parallel with oral supplementation, to treat solid tumors, and saw some clinical responses. Subsequent clinical trials failed to show any therapeutic benefit of high-dose vitamin C, but these failures might have been due to the intrinsically limited bioavailability of orally administered vitamin C (Padayatty and Levine, 2016). Intracellular vitamin C levels in humans vary from 1 mM in WBCs to 10 mM in brain cells.…”
Section: Discussionmentioning
confidence: 99%
“…vitamin C, in parallel with oral supplementation, to treat solid tumors, and saw some clinical responses. Subsequent clinical trials failed to show any therapeutic benefit of high-dose vitamin C, but these failures might have been due to the intrinsically limited bioavailability of orally administered vitamin C (Padayatty and Levine, 2016). Intracellular vitamin C levels in humans vary from 1 mM in WBCs to 10 mM in brain cells.…”
Section: Discussionmentioning
confidence: 99%
“…Vitamin C is low molecular weight antioxidant that is synthesized in the human organism. This vitamin is obtained with food (Padayatty, Levine, 2016.). Human body absorbs vitamin C from natural sources (Telang 2013, p. 143).…”
Section: Theoretical Framework -Requirement and Impact Of Vitamin C Fmentioning
confidence: 99%
“…Even so, it is unlikely that vitamin C in the beverage contributed to the findings, for several reasons. On the basis of the bioavailability data, 48 mg vitamin C ingested orally will have minimal effects on plasma concentrations, with a predicted increase of #10%, unless subjects were deficient at baseline (14,15). Although this is possible, it is not likely in 8 healthy athletic subjects, at least some of whom would be expected to make their food choices carefully.…”
mentioning
confidence: 99%