Vitamin D(25-OH-cholecalciferol) in Cystic Fibrosis and the Relations with Cholesterol and Proteins

Ciuca, I.M.; Pop, Liviu; Dediu, Mihaela; Tănăsescu, Sonia; Ardelean, Florina; Iovănescu, Gheorghe; Boeriu, Estera; Vlad, Cristina Daliborca; Marc, Monica; Guta, B. Almajan

doi:10.37358/rc.19.9.7512

Cited by 2 publications

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References 17 publications

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“…Vitamin D exposure results in the transition of a pro-inflammatory immune system to a more tolerant immune system based on the ability of calcitriol to inhibit the proliferation, differentiation, and modulation of T cells' production of cytokines [10]. Despite daily supplementation, patients with cystic fibrosis have low levels of vitamin D [11].…”

Section: Introductionmentioning

confidence: 99%

The Relation between Vitamin D Level and Lung Clearance Index in Cystic Fibrosis—A Pilot Study

et al. 2022

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Background: Life expectancy has increased in cystic fibrosis (CF) patients; however, the rate of mortality is still high, and in a majority of cases, the cause of death is due to respiratory deterioration. Vitamin D plays an important role in immunity and infection prophylaxis, as its deficiency is associated with frequent infections. In CF patients, a deficit of liposoluble vitamins is common, despite daily supplementation. The aim of this study is to evaluate the relation between vitamin D status and lung function expressed by lung clearance index (LCI) in patients with CF. We also assessed the relation of factors such as nutritional status, genotype, and associated comorbidities such as Pseudomonas infection, cystic fibrosis-related diabetes (CFRD), and cystic fibrosis liver disease (CFLD) with vitamin D and LCI. Methods: A cross-sectional study was conducted at the National Cystic Fibrosis Center by analyzing patients with CF who presented in our center between November 2017 and November 2019. We enrolled in the study patients diagnosed with CF, who were followed up in our CF center and who were able to perform lung function tests. Patients in exacerbation were excluded. Results: A strong negative correlation was found between vitamin D and LCI (r = −0.69, p = 0.000). A lower vitamin D storage was found in patients with CFLD and CFRD. Higher LCI values were found among patients with chronic Pseudomonas infection, with BMI under the 25th percentile, or with associated CFLD. Conclusion: In CF patients, vitamin D plays an important role, and its deficit correlates with an impaired LCI. Vitamin D deficit is a risk factor in patients with associated comorbidities such as CFLD and CFRD. Chronic infection with Pseudomonas, the presence of impaired nutritional status, and CFLD are associated with a prolonged LCI.

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Section: Introductionmentioning

confidence: 99%

The Relation between Vitamin D Level and Lung Clearance Index in Cystic Fibrosis—A Pilot Study

et al. 2022

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Vitamin D deficiency in patients with cystic fibrosis: a systematic review and meta-analysis

Farahbakhsh,

Fatahi,

Shirvani

et al. 2024

J Health Popul Nutr

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Aim Vitamin D is a prominent modulator of immunity and respiratory function. It plays a vital role in respiratory diseases such as cystic fibrosis (CF). S. However, there is a dearth of information on patients with CF. The purpose of the meta-analysis is to highlight the importance of following the existing guidelines regarding maintenance of Vitamin D serum levels in patients with CF. Methods The systematic search was conducted without utilizing any time or language limitations in original database from the beginning until March 2022. The meta-analysis was performed using a random-effects model. Heterogeneity was determined by I2 statistics and Cochrane Q test. Results Pooled analysis using the random-effects model of the 8 case–control studies with 13 effect sizes revealed that the serum 25-OH-vitamin D in participants with cystic fibrosis was significantly lower than controls in pediatrics and adolescences (WMD: − 3.41 ng/ml, 95% CI − 5.02, − 1.80, p = < 0.001) and adults (WMD: − 2.60 ng/ml, 95% CI − 4.32, − 0.89, p = 0.003). Based on data from 12 studies (21 effect sizes) with a total of 1622 participants, the prevalence of vitamin D levels of 20–30 ng/ml in CF patients was 36% among pediatrics/adolescents and 63% among adults. In addition, 27% of pediatric/adolescent CF patients and 35% of adult CF patients had vitamin D levels of below 20 ng/ml. Conclusions As a result, according to the existing guidelines, our results proved the need to pay attention to the level of vitamin D in these patients.

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Vitamin D(25-OH-cholecalciferol) in Cystic Fibrosis and the Relations with Cholesterol and Proteins

Cited by 2 publications

References 17 publications

The Relation between Vitamin D Level and Lung Clearance Index in Cystic Fibrosis—A Pilot Study

The Relation between Vitamin D Level and Lung Clearance Index in Cystic Fibrosis—A Pilot Study

Vitamin D deficiency in patients with cystic fibrosis: a systematic review and meta-analysis

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