Vitamin D (25OHD) Serum Seasonality in the United States

Kasahara, Amy K.; Singh, Ravinder J.; Noymer, Andrew

doi:10.1371/journal.pone.0065785

Cited by 115 publications

(105 citation statements)

References 41 publications

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“…In the northern hemisphere, 25(OH)D serum levels vary seasonally: its highest values are recorded in August and September, and its lowest in February [10,11]. In Europe at latitudes above 51 degrees, there is insufficient natural UV light for cutaneous vitamin D synthesis from September to March [12].…”

Section: Introductionmentioning

confidence: 99%

Powszechny niedobór witaminy D u dorosłych z województwa pomorskiego po miesiącach niskiego i wysokiego promieniowania UVB

Kmieć

Żmijewski²,

Lizakowska-Kmieć³

et al. 2015

Endokrynologia Polska

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Introduction: Widespread vitamin D deficiency has been reported worldwide and evidence of its deleterious effects on health has been accumulating. There is insufficient data concerning vitamin D status among the Polish adult population. The aim of the study was to determine vitamin D status and factors influencing it -UVB exposure, supplementation, and diet -among adults in northern Poland following months of low and high natural UVB radiation.

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Section: Introductionmentioning

confidence: 99%

Powszechny niedobór witaminy D u dorosłych z województwa pomorskiego po miesiącach niskiego i wysokiego promieniowania UVB

Kmieć

Żmijewski²,

Lizakowska-Kmieć³

et al. 2015

Endokrynologia Polska

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“…The difference between the control and the two supplemental groups lessened from the onset of the intervention to the end (Table 2 and Thus, from February to August, without evidence of an increase in the food intake of vitamin D in the control group, the status evolved from insufficiency to reach the lower range of sufficiency (50 nmol/L) according to the 2011 IOM report [4]. This evolution is in keeping with the seasonality influence on the vitamin D status, as studied in both European countries and the United States [11][12][13][14]32]. Quantitatively, serum 25OHD was shown to evolve from 38.5 to 64.0 nmol/L from March to August in community dwelling individuals ≥ 65 years (56.7% men) living in Southern Germany [13].…”

Section: 5dose-response and Seasonalitymentioning

confidence: 60%

“…However, this potential alternative is far from being straightforward. Indeed, the production of vitamin D3 by the skin is dependent upon several factors including seasonality, geographical location (latitude, altitude), ozone layer, cutaneous melanin pigment, aging, obesity and body mass index (BMI), let alone the widespread practice of sun avoidance and/or use of protection creams to curtail skin cancer risk [8,[11][12][13][14][15]. Therefore, taking all these various determinants into account, it remains a challenge to recommend the appropriate sunlight exposure "dose" in order to achieve a sufficient vitamin D status without increasing skin cancer risk [15][16][17].…”

Section: Introductionmentioning

confidence: 99%

“…Nevertheless, the impact of vitamin D3 intake on its status depends upon several factors including: i) dosage; ii) baseline 25OHD level; iii) season of the year. These three determinants have been identified in several observational or interventional studies [2,5,8,[12][13][14][18][19][20][21][22][23][24][25][26][27]. How these three determinants quantitatively interact remains to be documented in a single prospective study enrolling well-characterized subjects.…”

Section: Introductionmentioning

confidence: 99%

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Evolution of Serum 25OHD in Response to Vitamin D<sub>3</sub> Fortified-Yogurts Consumed by Healthy Menopausal Women: A Six-Month Randomized-Controlled Trial Assessing the Interactions between Doses, Baseline Vitamin D Status and Seasonality

Bonjour

Dontot-Payen²,

Rouy³

et al. 2017

Preprint

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A 24 week-controlled trial was conducted in menopausal women (mean age:61.5) to assess serum 25-hydroyvitaminD (s25OHD) evolution in relation to three interdependent determinants: doses of supplemented (Suppl.) vitamin D3 (VitD3); baseline status; seasonality.Participants were randomized into 3 groups (Gr): Gr.Suppl.0, time-controls maintaining dietary habits; Gr.Suppl.5 and Gr.Suppl.10 consuming one and two 125 g servings of VitD3-fortified yogurts with 5 and 10 µg daily doses, respectively. The 16 intervention-weeks lasted from early-January to mid-August, the 8 follow-up-weeks from late-August to mid-October.Before enrollment, subjects were randomized into two s25OHD strata: "Low stratum (LoStr)": 25-50 nmol/L; "High stratum (HiStr)": >50-75 nmol/L. All enrolled participants remained compliant until study end: Gr.Suppl.0 (n=45), Gr.Suppl.5 (n=44) Gr.Suppl.10 (n=44). Over the 16 intervention and 8 follow-up weeks, s25OHD increased in both supplemented groups, more in Gr.Suppl.10 than Gr.Suppl.5. The constant rate of s25OHD per supplemental VitD3 microgram was greater in LoStr than HiStr. s25OHD increase was greater with late (mid-March) than early (mid-January) inclusion. In conclusion, this randomized trial demonstrates: -a dose-dependent s25OHD improvement related to fortified yogurt consumption; -an inversely baseline-dependent increase in s25OHD; -a seasonal effect that highlights the importance of vitamin D3 supplementation during winter, even at 5µg/d, in healthy menopausal women.KEY WORDS: nutritional intervention; menopausal women; vitamin D3-fortified yogurts; serum 25OHD dose response; seasonality interaction Preprints (www.preprints.org) | NOT PEER-REVIEWED | Posted:

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“…25 (30)(31)(32)(33). Çalışmamızda sadece ilkbahar mevsimi olarak üç aylık süreç değerlendirilmiştir.…”

Section: Discussionunclassified

Evidence-Based Laboratory: Determining the Insufficiency Level of Vitamin D

Vurgun¹,

Evliyaoğlu²,

Yildirmak³

2016

Haseki

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ÖzAmaç: Türkiye'de yaşayan erişkinlerde D vitamini yetersizliğinin ve eksikliğinin tanımları açısından D vitamini düzeylerinin paratiroid hormon ile olan ilişkisine ait çalışmalara ihtiyaç vardır. Biz de paratiroid hormon düzeyinin 25-hidroksi vitamin D düzeyine göre sapma noktasını saptayıp, coğrafyamızdaki D vitamini yetersizliğinin ve eksikliğinin sınır değerleri açısından literatüre katkıda bulunmayı amaçladık.Yöntemler: Laboratuvar yazılım sisteminden 01.03.2015 ile 01.06.2015 tarihleri arasında çalışılmış tetkikleri olan hastalar tarandı. Eş zamanlı olarak istenmiş olan tetkiklerinden; kalsiyum, inorganik fosfat, kreatinin, intakt paratiroid hormon düzeyleri referans aralıkları içerisinde olup, 25-hidroksi vitamin D düzeyi <50 ng/mL olan 18 yaşından büyük 803 hasta retrospektif olarak çalışmaya dahil edildi. Bulgular:Yirmi beş-hidroksi vitamin D düzeyi 15-10 ile 10-5 ng/mL olan gruplardaki intakt paratiroid hormon düzeyleri arasında anlamlı farklılık tespit edildi (p=0,05). 25-hidroksi vitamin D düzeyleri 30 ile 10 ng/mL arasında iken, intakt paratiroid hormon düzeyleri arasındaki anlamlı farklılığın 22 ng/mL düzeyinde yani 50-22 ile 22-10 ng/ mL grupları arasında başladığı tespit edildi (p=0,01). Böylece, azalan 25-hidroksi vitamin D düzeylerine anlamlı intakt paratiroid hormon artışının ilk olarak 22 ng/mL düzeyinde olduğu ve daha sonra ilk artışa göre de anlamlı ikinci artışın 10 ng/mL düzeyinde olduğu tespit edildi. the results of patients older than 18 years were scanned from the laboratory information system. Eight hundred three patients, whose simultaneously analyzed serum levels of calcium, inorganic phosphate, creatinine and intact parathyroid hormone were within the reference ranges and 25-hydroxyvitamin D was <50 ng/mL, were included in the study. Results:There was a significant difference in intact parathyroid hormone levels between subjects with 25-hydroxyvitamin D levels of 15-10 and those with 10-5 ng/mL (p=0.05). A significant increase in intact parathyroid hormone levels (p=0.01) was found to start with a 25-hydroxyvitamin D level below 22 ng/mL within the range of 30 to 10 ng/mL. Consequently, we determined the first 25-hydroxyvitamin D threshold in which intact parathyroid hormone levels significantly increase to be 22 ng/mL and the second threshold as 10 ng/mL. Conclusion:Evaluation of parathyroid hormone which has a major role in the regulation of vitamin D should be done to define and diagnose vitamin D deficiency and insufficiency correctly.Keywords: Vitamin D deficiency, parathyroid hormone, calcium Abs tractYa z›fl maAd re si/Ad dressforCor res pon den ce:Eren Vurgun

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Vitamin D (25OHD) Serum Seasonality in the United States

Cited by 115 publications

References 41 publications

Powszechny niedobór witaminy D u dorosłych z województwa pomorskiego po miesiącach niskiego i wysokiego promieniowania UVB

Powszechny niedobór witaminy D u dorosłych z województwa pomorskiego po miesiącach niskiego i wysokiego promieniowania UVB

Evolution of Serum 25OHD in Response to Vitamin D<sub>3</sub> Fortified-Yogurts Consumed by Healthy Menopausal Women: A Six-Month Randomized-Controlled Trial Assessing the Interactions between Doses, Baseline Vitamin D Status and Seasonality

Evidence-Based Laboratory: Determining the Insufficiency Level of Vitamin D

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