Vitamin D

Li, Yan Chun

doi:10.1097/mnh.0b013e32834de4ee

Cited by 54 publications

(23 citation statements)

References 88 publications

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“…Stimulation of vitamin D receptors exerts protective activity through multiple mechanisms, including inhibition of the RAS, regulation of proliferation and differentiation, reduction of proteinuria, anti-inflammation, and anti-fibrosis [103] . Growing evidence indicates that vitamin D exerts anti-proteinuric and renoprotective effects in DKD patients.…”

Section: Vitamin D Receptor Activationmentioning

confidence: 99%

Clinical therapeutic strategies for early stage of diabetic kidney disease

Kitada

Kanasaki

Koya

2014

WJD

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Diabetic kidney disease (DKD) is the most common cause of chronic kidney disease, leading to end-stage renal disease and cardiovascular disease. The overall number of patients with DKD will continue to increase in parallel with the increasing global pandemic of type 2 diabetes. Based on landmark clinical trials, DKD has become preventable by controlling conventional factors, including hyperglycemia and hypertension, with multifactorial therapy; however, the remaining risk of DKD progression is still high. In this review, we show the importance of targeting remission/regression of microalbuminuria in type 2 diabetic patients, which may protect against the progression of DKD and cardiovascular events. To achieve remission/regression of microalbuminuria, several steps are important, including the early detection of microalbuminuria with continuous screening, targeting HbA1c < 7.0% for glucose control, the use of renin angiotensin system inhibitors to control blood pressure, the use of statins or fibrates to control dyslipidemia, and multifactorial treatment. Reducing microalbuminuria is therefore an important therapeutic goal, and the absence of microalbuminuria could be a pivotal biomarker of therapeutic success in diabetic patients. Other therapies, including vitamin D receptor activation, uric acid-lowering drugs, and incretin-related drugs, may also be promising for the prevention of DKD progression.

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Section: Vitamin D Receptor Activationmentioning

confidence: 99%

Clinical therapeutic strategies for early stage of diabetic kidney disease

Kitada

Kanasaki

Koya

2014

WJD

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“…As a predictor of CVD, hyperuricemia has been long observed to occur with an increased frequency among population with high risks for CVD [2], [3]. Moreover, some previous studies found that vitamin D deficiency was an independent risk factor for CVD [4] and a predictor of chronic kidney diseases [5]. Impaired renal function was suggested to raise serum uric acid (SUA) concentration by decreasing renal excretion [6].…”

Section: Introductionmentioning

confidence: 99%

Association between Vitamin D Insufficiency and Elevated Serum Uric Acid among Middle-Aged and Elderly Chinese Han Women

Peng

et al. 2013

PLoS ONE

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BackgroundAssociation between vitamin D insufficiency and hyperuricemia has not been reported so far. We aimed to study the association of vitamin D insufficiency with elevated serum uric acid among middle-aged and elderly Chinese Han women.MethodsWe collected data from participants residing in Jinchang district of Suzhou from January to May, 2010. Serum uric acid, 25-hydroxy vitamin D and other traditional biomarkers including fasting plasma glucose and blood lipids were determined in 1726 women aged above 30 years. Association between vitamin D insufficiency and elevated uric acid was analyzed in premenopausal and postmenopausal women, respectively.ResultsAmong postmenopausal women, 25-hydroxy vitamin D level of participants with elevated uric acid was lower than that of those with normal uric acid (median [interquartile range]: 35[28–57] vs 40[32–58], µg/L; P = 0.006). Elevated uric acid was more prevalent in participants with vitamin D insufficiency compared to those without vitamin D insufficiency (16.50% vs 8.08%; P<0.001). Association between vitamin D insufficiency and elevated uric acid was not significant among premenopausal women. However, participants with vitamin D insufficiency were more likely to have elevated uric acid compared with those without vitamin D insufficiency among postmenopausal women (OR, 95% CI: 2.38, 1.47–3.87). Moreover, after excluding individuals with diabetes and/or hypertension, the association of vitamin D insufficiency with elevated uric acid was still significant (OR, 95% CI: 2.48, 1.17–5.44).ConclusionsVitamin D insufficiency was significantly associated with elevated uric acid among postmenopausal Chinese Han women. This study suggested that a clinical trial should be conducted to confirm the association of vitamin D insufficiency with hyperuricemia.

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“…25(OH)D mediates its effects via ligand-regulated vitamin D receptors [24] expressed in target organs directly involved in calcium homeostasis (bones, kidneys, intestinal tract, and the parathyroid gland), as well as other target organs including skeletal muscles, smooth muscle cells, and myocardium [25]. Through selective activation of vitamin D receptors, 25(OH)D exerts hormonal, autocrine and paracrine actions [26] that are increasingly recognized as essential to maintaining cardiovascular health [27].…”

Section: Discussionmentioning

confidence: 99%

The Association of 25(OH)D with Blood Pressure, Pulse Pressure and Carotid-Radial Pulse Wave Velocity in African Women

Kruger

Doak³

et al. 2013

PLoS ONE

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High susceptibility of the African population to develop cardiovascular disease obliges us to investigate possible contributing risk factors. Our aim was to determine whether low 25(OH)D status is associated with increased blood pressure and carotid-radial pulse wave velocity in black South African women. We studied 291 urban women (mean age: 57.56±9.00 yrs.). 25(OH)D status was determined by serum 25(OH)D levels. Women were stratified into sufficient (>30 ng/ml), and insufficient/deficient (<30 ng/ml) groups. Cardiovascular variables were compared between groups. Women with low 25(OH)D levels had significantly higher SBP (150.8±27.1 vs. 137.6±21.0), DBP (94.7±14.5 vs. 89.3±12.3) and PP (53.15(50.7;55.7) vs. 46.3(29.4;84.6)) compared to women with sufficient levels. No significant difference was observed with regards to c-rPWV. ANCOVA analyses still revealed significant differences between the two groups with regards to SBP, DBP as well as PP. Partial correlations revealed significant inverse association between SBP and 25(OH)D (p = .04;r = −.12). Women with low 25(OH)D levels were ∼2 times more likely to have high SBP (95% CI: 3.23;1.05). To conclude, women with deficient/insufficient 25(OH)D had significantly higher SBP compared to women with a sufficient 25(OH) status.

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Vitamin D

Cited by 54 publications

References 88 publications

Clinical therapeutic strategies for early stage of diabetic kidney disease

Clinical therapeutic strategies for early stage of diabetic kidney disease

Association between Vitamin D Insufficiency and Elevated Serum Uric Acid among Middle-Aged and Elderly Chinese Han Women

The Association of 25(OH)D with Blood Pressure, Pulse Pressure and Carotid-Radial Pulse Wave Velocity in African Women

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