Vitamin D and aging

Tuohimaa, Pentti

doi:10.1016/j.jsbmb.2008.12.020

Cited by 98 publications

(97 citation statements)

References 86 publications

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“…Of course, our investigation can only be a rough estimate of the survival benefit of improving ectopic calcification, progressive loss of hearing and balance as well as a short lifespan. 21 The 25(OH)D data from the DEVID study (mean value: 41 nmol/l) we presented here are comparable with 25(OH)D concentrations obtained in adults who participated in the representative GNHIES study (median value: 45 nmol/l). 13 Therefore, results of 25(OH)D concentrations in the DEVID study seems to be generalizeable for the German population.…”

Section: Discussionsupporting

confidence: 82%

An estimate of the survival benefit of improving vitamin D status in the adult German population

Zittermann

Helden²,

Grant

et al. 2009

Dermato-Endocrinology

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IntroductionVitamin D is well known for its effects on calcium and bone metabolism. Vitamin D deficiency results in rickets in infants and small children and in osteomalacia and osteoporosis in adults. However, recent advances in the understanding of vitamin D have revolutionized our view of this old nutritional factor and suggested that it has much wider effects on the body than ever believed before. Major reasons for this situation are insufficient skin exposure to solar ultraviolet B radiation together with inadequate oral vitamin D intake.There is accumulating evidence that vitamin D deficiency/ insufficiency might contribute to the etiology of various chronic diseases such as cardiovascular disease, specific types of cancer, multiple sclerosis, and type 1 diabetes.3,4 Recent studies demonstrated that poor vitamin D status is independently associated with excess cancer mortality 7 and poor outcome in congestive heart failure individuals. 8 In addition, poor vitamin D status is associated with excess all-cause mortality in individuals with end-stage renal disease. 9 In 2007, Autier and Gandini 10 published a meta-analysis of randomized controlled trials on vitamin D and total mortality that were not primarily designed to assess mortality. The authors concluded that vitamin D supplementation is linked to lower all-cause mortality in middle-aged and elderly individuals with low serum concentrations of 25(OH)D than in unsupplemented subjects. Risk reduction was 7% during a mean follow-up of 5.7 years.Background: Inadequate vitamin D status is a worldwide problem. Evidence is accumulating that individuals with low vitamin D status have excess mortality rates. We calculated to which extent annual mortality rates can be reduced in the German population by optimizing vitamin D status.Results: Mean serum concentrations of 25-hydroxyvitamin D in the DEVID study cohort were 41 nmol/l (SD: 22 nmol/l). More than 90% of individuals had 25-hydroxyvitamin D concentrations below the threshold that was associated with lowest mortality risk in the two aforementioned trials (75 nmol/l). According to conservative estimations, at least 2.2% of all deaths or 18,300 lives annually can be saved by achieving 25(oH)D concentrations of at least 75 nmol/l in the entire adult German population. Available data provide evidence for an exponential increase in total mortality with deficient 25-hydroxyvitamin D concentrations.Methods: our calculations are based on (1) an annual mortality rate of 1.34% in the adult German population as provided by the Statistical Yearbook, (2) the actual vitamin D status in German adults with a high mortality risk as assessed in 1,343 individuals from 264 general practitioners in different German regions (DEVID study), and (3) data from two very large prospective cohorts (Dobnig et al. 2008;Melamed et al. 2008) about the excess mortality in individuals with inadequate vitamin D status.Conclusion: Improving vitamin D status in a population with inadequate vitamin D status might be an effective strategy to reduc...

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Section: Discussionsupporting

confidence: 82%

An estimate of the survival benefit of improving vitamin D status in the adult German population

Zittermann

Helden²,

Grant

et al. 2009

Dermato-Endocrinology

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“…Ϫ/Ϫ mice) results in growth retardation, osteoporosis, kyphosis, skin thickening and wrinkling, ectopic calcification, progressive loss of hearing, and short lifespan (22 ). Notably, in immunosuppressed solid-organ transplanted animals 1,25(OH) 2 D administration improved survival significantly (23,24 ).…”

Section: Discussionmentioning

confidence: 99%

Effect of Vitamin D or Activated Vitamin D on Circulating 1,25-Dihydroxyvitamin D Concentrations: A Systematic Review and Metaanalysis of Randomized Controlled Trials

Zittermann¹,

Ernst²,

Birschmann

et al. 2015

Clinical Chemistry

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“…[8][9][10] Long lactation periods, the use of skin sun blockers, the frequent use of umbrellas, 3,11,12 tobacco smoking, obesity and renal chronic disease have been also associated with VDD in women. 3,[11][12][13][14][15][16] It is not clear whether the VDD is produced by obesity or obesity is a consequence of VDD, 17 because obese individuals specially women, 18 are susceptible to VDD due to diminished availability of VD stored in the adipose tissue, and on the other hand, 18 some studies in obese individuals suggest that the supplementation with VD reduces the body fat mass. [19][20][21] Women at reproductive age are a group that can be intervened at earlier age for VDD and its long term complications.VDD during adulthood increases the risk of osteopenia, osteoporosis, muscle weakness, osteomalasia and pathological fractures and can worsen other chronic conditions, such as the polycystic ovary syndrome; it also is a risk factor for cardiovascular diseases, metabolic syndrome, some types of cancer and some autoimmune diseases.…”

Section: Vitamin D Status In Mexican Womenmentioning

confidence: 99%

“…[19][20][21] Women at reproductive age are a group that can be intervened at earlier age for VDD and its long term complications.VDD during adulthood increases the risk of osteopenia, osteoporosis, muscle weakness, osteomalasia and pathological fractures and can worsen other chronic conditions, such as the polycystic ovary syndrome; it also is a risk factor for cardiovascular diseases, metabolic syndrome, some types of cancer and some autoimmune diseases. [16][17][18][19][20][21][22][23][24] This study aims to describe the prevalence of VDD and VDI, and the dietary sources of VD, in a probabilistic sample of women at reproductive age participating in Ensanut-2012, stratified by sociodemographic factors and BMI categories.…”

Section: Vitamin D Status In Mexican Womenmentioning

confidence: 99%

Vitamin D status by sociodemographic factors and body mass index in Mexican women at reproductive age

Contreras‐Manzano¹,

Villalpando²,

Robledo-Pérez³

2017

Salud Publica Mex

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Vitamin D and aging

Cited by 98 publications

References 86 publications

An estimate of the survival benefit of improving vitamin D status in the adult German population

An estimate of the survival benefit of improving vitamin D status in the adult German population

Effect of Vitamin D or Activated Vitamin D on Circulating 1,25-Dihydroxyvitamin D Concentrations: A Systematic Review and Metaanalysis of Randomized Controlled Trials

Vitamin D status by sociodemographic factors and body mass index in Mexican women at reproductive age

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