Vitamin D and associated factors, among pregnant women in southeastern Nigeria

Adinma, J. I. B.; Ahaneku, Joseph Eberendu; Adinma, ED; Ugboaja, JO; Okolie, V.; Adinma-Obiajulu, Nneoma Dolores; Edet, Mark Mathew

doi:10.1080/01443615.2021.1931068

Cited by 3 publications

(5 citation statements)

References 34 publications

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“…This result is not in line with [29]. This was a cross-sectional study, conducted among 311 secondary school adolescent girls (10 -19 years) from two secondary schools (one boarding school and one day school) in Nnewi North LGA of Anambra State of south-eastern Nigeria between May and June 2018.…”

Section: B Effect Of Economic Status On Menarchementioning

confidence: 85%

Factors Influencing Age at Menarche, a School-Based Cross-Sectional Study

Novalia

Sumasto

Saadah

et al. 2022

International Journal of Advanced Health Science and Technology

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The last few years have seen the increasingly young age of menarche in teenagers. The average age of the national menarche from year to year is declining. The more children experience early menarche, the greater the risk of negative implications such as lack of personal hygiene, breast cancer, and early pregnancy. Menarche's age is influenced by nutritional, economic, pornographic, and genetic status. The purpose of this study was to determine the factors that affect menarche in adolescents aged 10-12 years. The research conducted is descriptive-analytic with a cross-sectional design. The population of MIN 3 Magetan students aged 10-12 years who have menstruated and have met the inclusion and exclusion criteria. The study sample was 87 respondents with a purposive sampling technique. Data collection using questionnaires. Statistical calculations are carried out by statistical and descriptive analysis with binary logistic regression tests. The average age of menarche is 11 years with the youngest age being 9 years and the oldest at 12 years, most female students experience early menarche (65.5%). There is an effect of nutritional status on menarche (p =0.048, Exp (B)= 4.3), there is an economic influence on menarche (p=0.000, Exp (B)= 11.3), there is an influence of pornographic exposure on menarche (p=0.001, Exp (B)= 12.1), and there is no genetic or age influence maternal menarche against menarche (0.388). Nutritional status, economic status, and exposure to pornographic media increase the incidence of early menarche. The highest risk factors for exposure to pornography resulted in 12.1 times the incidence of early menarche, economic status by 11.3 times, and nutritional status by 4.2 times. Strict supervision of mass media access and maintaining nutritional intake are necessary to prevent early menarche.

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Section: B Effect Of Economic Status On Menarchementioning

confidence: 85%

Factors Influencing Age at Menarche, a School-Based Cross-Sectional Study

Novalia

Sumasto

Saadah

et al. 2022

International Journal of Advanced Health Science and Technology

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“…We also measured the metabolites 3-epi-25(OH)D 3 and 24,25(OH) 2 D 3 in our study; normal levels for these metabolites have not yet been determined. With regards to 3-epi-25(OH)D 3 , however, distinguishing between 25(OH)D and 3-epi 25(OH)D 3 is of biological relevance, particularly in infants; 3-epi-25(OH)D 3 accounts for a significant proportion of the circulating total 25(OH)D and increases at the end of the pregnancy and decreases over the first year of life [ 20 ]. Access to an adequate assay method such as LC-MS/MS can help provide an accurate measurement.…”

Section: Discussionmentioning

confidence: 99%

“…El-Khateeb et al, in a study conducted in Jordan, found that low 25(OH)D levels were associated with women being unemployed ( p < 0.001) [ 49 ]. Brian et al found in a study of pregnant women in Nigeria that the workplace location was associated with 25(OH)D status; women who worked indoors had lower 25(OH)D levels than those who worked outdoors ( p < 0.031) [ 20 ]. However, we did not specifically ask our study participants about the amount of sunlight exposure they had daily, nor did we inquire about the details of their jobs if they were employed.…”

Section: Discussionmentioning

confidence: 99%

“…In a 2021 Nigerian study, a low vitamin D level in children aged 1–59 months was associated with an increased risk of acute pneumonia [ 19 ]. In addition to increased susceptibility to infections, studies have shown an association between maternal vitamin D deficiency and pregnancy complications such as intrauterine growth restriction, increased caesarian sections, and preterm birth [ 20 ]. Maternal risk factors that have been associated with maternal 25(OH)D deficiencies include the type of maternal employment and educational level [ 21 ].…”

Section: Introductionmentioning

confidence: 99%

“…A 2019 study by Oluwole showed that the prevalence of serum 25(OH)D deficiency was higher among women with preterm delivery than among those with term delivery [ 24 ]. No study, however, has assessed the impact of 25(OH)D and associated metabolites status on pregnancy and newborn outcomes in Nigeria [ 20 , 25 , 26 ]. No studies with the Nigerian populations have looked at associations of maternal-infant vitamin D and metabolite levels with the above risk factors and outcomes.…”

Section: Introductionmentioning

confidence: 99%

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Vitamin D Metabolites in Mother–Infant Dyads and Associated Clinical Outcomes in a Population of Nigerian Women

Delair,

Anderson-Berry,

Olateju

et al. 2024

Nutrients

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Low levels of vitamin D in maternal and cord blood have been associated with neonatal sepsis. This study assessed the association of vitamin D metabolites (25(OH)D, 3-epi-25(OH)D3, and 24,25(OH)2D3) levels in maternal and cord blood with newborn sepsis evaluation in Nigerian mother–infant dyads. Maternal and cord blood from 534 mothers and 536 newborns were processed using liquid chromatography-tandem mass spectrometry. Spearman correlation was used to compare continuous variables, Mann–Whitney for dichotomous variables, and Kruskal–Wallis for two or more groups. High cord percent 3-epi-25(OH)D3 levels were positively associated with newborn evaluation for sepsis (p = 0.036), while maternal and cord 25(OH)D and 24,25(OH)2D3 levels were not. Being employed was positively associated with maternal and newborn 3-epi-25(OH)D3 concentrations (p = 0.007 and p = 0.005, respectively). The maternal 3-epi-25(OH)D3 and percent 3-epi-25(OH)D3 were positively associated with vaginal delivery (p = 0.013 and p = 0.012, respectively). Having a weight-for-age Z-score ≤ −2 was positively associated with newborn percent 3-epi-25(OH)D3 levels (p = 0.004), while a weight-for-length Z-score ≤ −3 was positively associated with maternal and newborn percent 3-epi-25(OH)D3 levels (p = 0.044 and p = 0.022, respectively). Our study highlights the need to further investigate the biological role of 3-epi-25(OH)D3 and its clinical significance in fetal growth and newborn outcome.

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Assessment of Vitamin D status of patients with human immunodeficiency virus

Edet,

Mbachu,

Adinma

et al. 2024

Advances in Biomedical and Health Sciences

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Background: Vitamin D regulates calcium and phosphorus homeostasis. Vitamin D deficiency (VDD) commonly occurs in people living with human immunodeficiency virus (HIV) (PLWHIV) and is linked to bone disorders and metabolic and infectious diseases. HIV seropositivity and VDD may worsen the consequences on the individual. Methods: A cross-sectional analytical study was conducted using 90 serum samples from 42 HIV-positive and 48 HIV-negative patients attending the Nnamdi Azikiwe University Teaching Hospital (NAUTH). This study was approved by the NAUTH Ethics Committee. Serum Vitamin D levels were analyzed using enzyme-linked immunosorbent assay. Sociodemographic data were obtained using a questionnaire. Data analysis was performed using IBM SPSS Windows version 27, and P < 0.05 was considered statistically significant. Results: Overall, 13.3% of the population had suboptimal Vitamin D levels, with 2.2% having VDD and 11.1% having Vitamin D insufficiency. VDD was found in 2.2% and 2.1% of the HIV-positive group and HIV-negative groups, respectively. No significant difference was observed in mean serum Vitamin D levels between the two groups (P > 0.05). Within the HIV-positive group, education, place of living, and skin coloration were associated with suboptimal Vitamin D levels, and only skin coloration was associated with HIV-negative subjects. Conclusion: VDD is relatively low in the region; however, it may contribute to poor bone health in PLWHIV. Interventions should target individuals with poor educational attainment, living in rural domains, or dark skin coloration. Studies with large sample size are needed to determine the effects of Vitamin D supplementation or exposure to sunlight on HIV infection.

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Vitamin D and associated factors, among pregnant women in southeastern Nigeria

Cited by 3 publications

References 34 publications

Factors Influencing Age at Menarche, a School-Based Cross-Sectional Study

Factors Influencing Age at Menarche, a School-Based Cross-Sectional Study

Vitamin D Metabolites in Mother–Infant Dyads and Associated Clinical Outcomes in a Population of Nigerian Women

Assessment of Vitamin D status of patients with human immunodeficiency virus

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