Vitamin D and autoimmune diabetes

Zella, Julia B.; DeLuca, Hector F.

doi:10.1002/jcb.10347

Cited by 135 publications

(90 citation statements)

References 40 publications

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“…Based on our correlation coefficients, present data are within the range observed previously (Kroke et al, 1999), indicating (Harbige, 1996). The deficiency of vitamin D, whose biologically active form is a potent modulator of the immune system, has been suggested among the dietary putative etiological factors in the pathogenesis of T1DM (Akerblom et al, 2002;Zella & DeLuca, 2003). However, vitamin D is rather a hormone.…”

Section: Discussionsupporting

confidence: 83%

Dietary habits and nutritional biomarkers in Italian type 1 diabetes families: evidence of unhealthy diet and combined-vitamin-deficient intakes

et al. 2004

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Objective: Nutritional status and lifestyle can have profound effects on health. To analyse behaviour patterns in population subgroups of public health importance, we compared lifestyle, dietary intake of energy and selected nutrients, and nutritional biomarkers of type 1 diabetes (T1DM) patients and nondiabetic first-degree relatives against control subjects with no family history of T1DM. Design: A cross-sectional study. Setting: Department of Internal Medicine, University of Pisa, Italy. Subjects: A total of 209 individuals including 38 type 1 patients, 76 relatives, and 95 healthy subjects. Interventions: We used the European Prospective Investigation of Cancer and Nutrition questionnaires to assess dietary intake and lifestyle. Anthropometric indices and nutritional biomarkers (such as plasma levels of albumin, iron, lipids, homocysteine, vitamin B 9 and vitamin B 12 as well as urinary outputs of nitrogen, sodium and potassium) were evaluated. Results: Emerging health issues: (1) In total, 45% of controls were overweight. Increasing age was associated with increasing body mass and decreasing activity in sport in front of an unchanged energy intake.(2) The distribution of energy sources was incorrect. The proportion of caloric intake derived from total fat and cholesterol did not match general guidelines. Total dietary fibre consumption was assessed to be adequate (25 g/day) in only 27% of all the participants. (3) Estimated daily intakes of water-soluble vitamin B 9 and fat-soluble vitamin D and vitamin E were deficient in comparison with dietary reference intakes. (4) The prevalence of adoption and maintenance of healthful eating and physical activity habits was higher in women and T1DM patients (probably as a consequence of the medical educational intervention). On the contrary, supportiveness of the family in term of changing the undesirable behaviours at home seemed to fail. Conclusions: This study provides first evidence indicating unhealthy dietary behaviours, which could even predispose to the development of diabetes and cardiovascular complications, in subjects living in Pisa. The combination of vitamin B 9 and vitamin E deprivation could be deleterious for endothelial function, since these antioxidants have been implicated in the modulation of nitric oxide and eicosanoid signalling.

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Section: Discussionsupporting

confidence: 83%

Dietary habits and nutritional biomarkers in Italian type 1 diabetes families: evidence of unhealthy diet and combined-vitamin-deficient intakes

et al. 2004

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“…There is evidence that vitamin D regulates beta-cell function by either influencing insulin secretion, inhibiting beta-cell apoptosis, or by increasing beta-cell replication (28). In the context of T1DM, vitamin D has a significant role in altering self-immunity leading to diabetes (29). Assessing the data on the incidence of T1DM in children < 14 years in 51 regions across the globe, incidence rate of T1DM approached zero in regions with high UVB irradiance (30).…”

Section: Discussionmentioning

confidence: 99%

High prevalence of vitamin D deficiency among newly diagnosed youth-onset diabetes mellitus in north India

Daga

Laway

Shah

et al. 2012

Arq Bras Endocrinol Metab

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OBJECTIVES: Vitamin D deficiency is common at all ages, and low levels of vitamin D have been associated with high incidence of type 1 diabetes. Similar results are not consistent for type 2 diabetes. The aim of the present study was to estimate vitamin D status in newly detected youth-onset diabetes in north India. SUBJECTS AND METHODS: This was a prospective case control study at a tertiary care hospital in north India. Seventy two newly detected youth-onset diabetes subjects (age < 25 years), and 41 age- and gender-matched healthy controls were studied. In addition to basic information and management regarding their diabetes, metabolic parameters and serum 25(OH)D were measured in both the groups. RESULTS: Vitamin D deficiency was seen in 91.1% of the subjects with diabetes, and 58.5% of the healthy controls. Mean ±SD 25(OH)D was significantly low, 7.88 ± 1.20 ng/mL in subjects with diabetes against 16.64 ± 7.83 ng/mL in controls. Sixty percent of cases had severe Vitamin D deficiency compared with 8.3% in controls. Levels of vitamin D did not correlate with clinical parameters, such as gender, body mass index; or with biochemical parameters, such as serum calcium, phosphorus, alkaline phosphatase, fasting plasma glucose, and HbA1C. CONCLUSION: Vitamin D deficiency is common in people with youth-onset diabetes.

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“…Also, polymorphism in the vitamin D receptor gene has been shown to be associated with susceptibility to type 1 diabetes [8]. The biologically active form of vitamin D may be a modulator of the immune system [9]. Chemokines produced by beta cells recruit pathogenic [10] and regulatory T cells [11].…”

Section: Introductionmentioning

confidence: 99%

Lower levels of plasma 25-hydroxyvitamin D among young adults at diagnosis of autoimmune type 1 diabetes compared with control subjects: results from the nationwide Diabetes Incidence Study in Sweden (DISS)

Blom²,

et al. 2006

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Aims/hypothesis Low plasma vitamin D concentrations may promote the development of type 1 diabetes. To test this hypothesis, we measured plasma 25-hydroxyvitamin D (25OHD) in young adults with type 1 diabetes. Methods The nationwide Diabetes Incidence Study in Sweden (DISS) covers 15-to 34-year-old people with newly diagnosed diabetes. Blood samples at diagnosis were collected during the 2-year period 1987/1988. Patients with islet antibodies (islet cell antibodies, GAD antibodies or tyrosine phosphatase-like protein antibodies) were defined as having autoimmune type 1 diabetes. Plasma 25OHD was measured in samples taken from 459 patients at the time of diagnosis, and in 138 of these subjects 8 years later. The results were compared with age-and sex-matched control subjects (n=208). Results At diagnosis, plasma 25OHD levels were significantly lower in patients with type 1 diabetes than in control subjects (82.5T1.3 vs 96.7T2.0 nmol/l; p<0.0001). Eight years later, plasma 25OHD had decreased in patients

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Vitamin D and autoimmune diabetes

Cited by 135 publications

References 40 publications

Dietary habits and nutritional biomarkers in Italian type 1 diabetes families: evidence of unhealthy diet and combined-vitamin-deficient intakes

Dietary habits and nutritional biomarkers in Italian type 1 diabetes families: evidence of unhealthy diet and combined-vitamin-deficient intakes

High prevalence of vitamin D deficiency among newly diagnosed youth-onset diabetes mellitus in north India

Lower levels of plasma 25-hydroxyvitamin D among young adults at diagnosis of autoimmune type 1 diabetes compared with control subjects: results from the nationwide Diabetes Incidence Study in Sweden (DISS)

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