Vitamin D and Bone Mineral Density in HIV Newly Diagnosed Therapy-Naive Patients Without Any Secondary Causes of Osteoporosis

Ceballos, María Elena; Carvajal, Camila; Jaramillo, J. J.; Domínguez, Angélica; González, Gilberto

doi:10.1007/s00223-018-0474-5

Cited by 11 publications

(14 citation statements)

References 38 publications

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“…In this sense, Paccou J et al (12) involving 49 naïve men, mean age was 31.6 ( 7.7) years demonstrated that the prevalence of low BMD was 24.5% 95% CI, 13.3-38.9 , similar to our ndings. In another study by Ceballos et al (11) involving 70 naïve men, mean age 31 years (19-50), Low BMD (Z-score < -2.0) was found in 13% of the patients.…”

Section: Discussionmentioning

confidence: 89%

Bone Involvement in Antiretroviral-Therapy–Naïve HIV-Infected Young Men

Atencio¹,

Cabello²,

Conesa-Buendía³

et al. 2020

Preprint

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Background: Low bone mineral density has been described as a non–AIDS (Acquired Immune Deficiency Syndrome)-related event in HIV (human immunodeficiency virus)-patients but it is poorly studied in young HIV-infected men who have received no previous antiretroviral therapy.Methods: A cross-sectional study of 245 naïve-HIV-infected men over 21 and under 50 years old was carried out between January 2014 and September 2017. Results: The mean age was 36.4 years, been 68% Caucasian and 29.3% Latin American. At the time of diagnosis, 91% of patients had stage-A (median CD4+ T-cell 481cells/μL, IQR, 320–659). 10% had a count below 200 CD4 cells/μL, and 40% had a CD4/CD8 cell-count-ratio below 0.4. Regarding lifestyle and risk factors, 14.1% presented underweight, 36.1% engaged in no regular exercise, 51.9% had previous exposure to tobacco and 35.3% reported drug use. Low levels of vitamin D were seen in 87.6% of the men studied. Low BMD (Z-score<2.0) was found in 22,8% of the patients. Conclusions: We find prevalence of bone involvement among naïve HIV-infected men under 50 years old. Further studies are necessary to evaluate if BMD assessment should be recommended in young HIV-infected patients.

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Section: Discussionmentioning

confidence: 89%

Bone Involvement in Antiretroviral-Therapy–Naïve HIV-Infected Young Men

Atencio¹,

Cabello²,

Conesa-Buendía³

et al. 2020

Preprint

View full text Add to dashboard Cite

show abstract

“…In this sense, Paccou J et al [ 12 ] involving 49 naïve men, mean age was 31.6 (±7.7) years demonstrated that the prevalence of low BMD was 24.5% [95% CI, 13.3–38.9], similar to our findings. In another study by Ceballos et al [ 11 ] involving 70 naïve men, mean age 31 years (19–50), Low BMD (Z-score < − 2.0) was found in 13% of the patients.…”

Section: Discussionmentioning

confidence: 96%

“…Our purpose is to provide information on bone situation in antiretroviral-therapy–naïve HIV-infected adult male under 50 years of age. It is expected that study participants will have the presence of an increased bone involvement than similar uninfected population, even prior to initiation of ART and under 50 years [ 11 , 12 ], which could suggest the beginning of the bone study prior to 50 years of age.…”

Section: Introductionmentioning

confidence: 99%

Increased risk factors associated with lower BMD in antiretroviral-therapy–naïve HIV-infected adult male

et al. 2021

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Background Low BMD (bone mineral density) has been described as a non–AIDS (Acquired Immune Deficiency Syndrome)-related event in HIV (human immunodeficiency virus)-patients but it is poorly studied in young HIV-infected men who have received no previous antiretroviral therapy. Methods A cross-sectional study of 245 naïve-HIV-infected men over 21 and under 50 years old who voluntary attended the Infectious Disease Division appointment in Hospital Fundación Jimenez Díaz in Madrid, from January 1st, 2014 to September 30th, 2017. All subjects underwent a baseline DXA scan (dual energy x-ray absorptiometry) performed prior to start antiretroviral treatment. Further, all patients who started treatment between May 1st and September 30th, 2017 were invited to participate in a substudy on bone mineral metabolism. All the information was collected through clinical history and complementary questionnaire. Results The mean age was 36.4 years, been 68% Caucasian, 29.3% Latin American and 2.7% African race. At the time of diagnosis, 91% of patients had stage-A (median CD4+ T-cell 481cells/μL, IQR, 320–659). 10% had a count below 200 CD4 cells/μL, and 40% had a CD4/CD8 cell-count-ratio below 0.4. Regarding lifestyle and risk factors, 14.1% presented underweight, 36.1% were not engage in any regular exercise, 51.9% were active smokers and 35.3% reported drug use. Low levels of vitamin D were seen in 87.6% of the study participants. Low BMD (Z-score <- 2.0) was found in 22.8% of the patients. It was only observed a significant association of Z-score in lumbar spine (LS) with CD8 and the CD4/CD8 ratio, and with alcohol for femoral neck (FN) measurement. Conclusions We find prevalence of increased bone involvement among naïve HIV-infected men under 50 years old. Further studies are necessary to evaluate if changes in actual guidelines are needed to assess BMD measurements in HIV-infected adult male patients under 50.

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“…In addition, vitamin D may have a crucial role in bone osteoporosis, which may be essential in migrants and individuals with HIV infection [39][40][41][42][43]. Child neglect cases discovered in forensic practice and unpublished cases debated only in courts may represent the tip of an iceberg [29,44].…”

Section: Vitamin Dmentioning

confidence: 99%

Vitamin D and Primary Ciliary Dyskinesia: A Topic to Be Further Explored

Sergi

2021

Applied Sciences

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Primary ciliary dyskinesia (PCD) is a genetic disease characterized by abnormalities in ciliary structure/function. The diagnosis of PCD relies on a combination of clinical evaluation and ultrastructural (electron microscopic) analysis of the ciliary architecture. This diagnosis may be challenging due to clinical and genetic heterogeneity and artifacts during the ciliary ultrastructure preparation and assessment. Recently, vitamin D supplementation has been proposed for several groups probably suffering from D-hypovitaminosis. Some patients with inflammatory bowel disease may have significant malabsorption, and vitamin D supplementation in these patients is recommended. Two recent reports suggest that a low plasmatic level of this vitamin is present in the PCD population. The utility of vitamin D supplementation may be essential in this group of individuals, and further investigations are warranted. Still, in examining the literature papers, it seems relevant that the authors concentrate solely on lung function in both studies. Future studies should probably target the intestinal function in patients with PCD independently from the vitamin D supplementation to fully evaluate its role.

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Vitamin D and Bone Mineral Density in HIV Newly Diagnosed Therapy-Naive Patients Without Any Secondary Causes of Osteoporosis

Cited by 11 publications

References 38 publications

Bone Involvement in Antiretroviral-Therapy–Naïve HIV-Infected Young Men

Bone Involvement in Antiretroviral-Therapy–Naïve HIV-Infected Young Men

Increased risk factors associated with lower BMD in antiretroviral-therapy–naïve HIV-infected adult male

Vitamin D and Primary Ciliary Dyskinesia: A Topic to Be Further Explored

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