Vitamin D and calcium dysregulation in the polycystic ovarian syndrome

Thys-Jacobs, Susan; Donovan, Daniel S.; Papadopoulos, Anatasio; Sarrel, Philip M.; Bilezikian, John P.

doi:10.1016/s0039-128x(99)00012-4

Cited by 171 publications

(138 citation statements)

References 19 publications

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“…Ten intervention trials had been carried out and published until our search in January 2013 (30,31,32,33,34,35,36,37,38,39,40). Among these, four had a randomized controlled trial (RCT) design (30,35,36,40), five an open-labeled single-arm design (32,33,37,38,39), and one a case-control study design (31).…”

Section: The Effect Of Vitamin D Supplementation In Women With Pcosmentioning

confidence: 99%

“…Among these, four had a randomized controlled trial (RCT) design (30,35,36,40), five an open-labeled single-arm design (32,33,37,38,39), and one a case-control study design (31). One RCT carried out by Ardabili et al had a randomized placebo-controlled double-blind study design in which the effect of vitamin D3 supplementation on metabolic parameters and cardiovascular risk factors was evaluated in 50 PCOS women.…”

Section: The Effect Of Vitamin D Supplementation In Women With Pcosmentioning

confidence: 99%

“…Vitamin D status and BMI Data on the association between anthropometric parameters and serum 25OHD were provided in 23 of the 29 reviewed studies (18,19,20,21,22,23,24,26,27,28,29,30,31,32,33,34,36,37,38,39,41,43,45), and nine studies reported these data also for control women (19,20,22,23,24,27,28,41,45). After regression analyses of the weighted means including a total of 2045 PCOS women and 717 control women, BMI appeared to be an independent predictor of serum 25OHD in both PCOS and control women (B 1 ZK4.5, P!0.001 and B 1 ZK8.4, P!0.001; Fig.…”

Section: The Effect Of Vitamin D Supplementation In Women With Pcosmentioning

confidence: 99%

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The role of vitamin D in metabolic disturbances in polycystic ovary syndrome: a systematic review

Krul-Poel

Snackey

Louwers

et al. 2013

European Journal of Endocrinology

115

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Context: Metabolic disturbances, in particular, insulin resistance (IR) and dyslipidemia, are common in women suffering from polycystic ovary syndrome (PCOS). Evidence is accumulating that vitamin D status may contribute to the development of metabolic disturbances in PCOS. Objective: The aim of this study was to carry out a systematic review addressing the association between vitamin D status, vitamin D receptor polymorphisms, and/or polymorphisms related to vitamin D metabolism and metabolic disturbances in women with PCOS. Design and methods: A systematic search of electronic databases was carried out up to January 2013 for observational studies and clinical trials in women suffering from PCOS with outcome measures that were related to vitamin D status. We conducted univariate and multivariate regression analyses of the weighted means to gain insights into the association between vitamin D, BMI, and IR based on existing literature. Results: We found 29 eligible trials with inconsistency in their results. One well-designed randomized controlled trial has been carried out until now. Univariate regression analyses of the weighted means revealed vitamin D to be a significant and independent predictor of IR in both PCOS and control women. The significance disappeared after adjustment for BMI in PCOS women. Conclusions: Current evidence suggests an inverse association between vitamin D status and metabolic disturbances in PCOS. Owing to the heterogeneity of the studies, it is hard to draw a definite conclusion. The causal relationship between vitamin D status and metabolic disturbances in PCOS remains to be determined in well-designed placebo-controlled randomized clinical trials.

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Section: The Effect Of Vitamin D Supplementation In Women With Pcosmentioning

confidence: 99%

Section: The Effect Of Vitamin D Supplementation In Women With Pcosmentioning

confidence: 99%

Section: The Effect Of Vitamin D Supplementation In Women With Pcosmentioning

confidence: 99%

See 1 more Smart Citation

The role of vitamin D in metabolic disturbances in polycystic ovary syndrome: a systematic review

Krul-Poel

Snackey

Louwers

et al. 2013

European Journal of Endocrinology

115

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“…[11][12][13][14][15][16][17][18][19][20] Among these, four had a randomized controlled trial design, [11][12][13][14][15][16][17][18][19][20][21] and one a case-control study design. 12 Different treatment protocols of vitamin D supplementation were used in the trials, varying from 400 IU a day in the trial carried out by Rashidi et al 15 The followup duration ranged from 3 weeks to 6 months.…”

Section: Effect Of Vitamin D Supplementation In Women With Pcosmentioning

confidence: 99%

Relationship between Vitamin D and Insulin Resistance in Polycystic Ovary Syndrome Women

Singh¹,

Agrawal²,

Garg³

et al. 2017

Journal of South Asian Federation of Obstetrics and Gynaecology

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“…40 There is some suggestion that the combination of vitamin D deficiency, together with dietary calcium insufficiency may contribute to the menstrual abnormalities in PCOS. 41 In a study of fifty seven women with PCOS, Wehr et al showed that vitamin D treatment might improve glucose metabolism and menstrual frequency in PCOS women. 36 Li et al demonstrated that ,Vitamin D deficiency is highly prevalent in women with PCOS in Scotland, and their study supported the evidence that vitamin D deficiency is associated with multiple metabolic risk factors in PCOS women.…”

Section: Association Of Vitamin D With Pcosmentioning

confidence: 99%

Comparison of vitamin D levels in obese and non obese patients with polycystic ovarian syndrome in a South Indian population

Lakshman

Pillai

Lakshman

et al. 2013

Int J Reprod Contracept Obstet Gynecol

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Polycystic ovary syndrome (PCOS) is the most common metabolic abnormality occurring in young women of reproductive age. Low vitamin D levels were found to be associated with the development of obesity and insulin resistance in young women with PCOS. The study was conducted as a prospective observational study involving 121 women with PCOS. The diagnosis of PCOS cases were based on the revised Rotterdam consensus criteria. Vitamin D levels were compared in the obese and non obese PCOS groups and also with the controls. In the PCOS group, sixty subjects were obese with BMI of ≥25 kg/m2 and forty seven subjects were found to be non obese. In the control group, sixteen subjects were obese and sixty five subjects were non obese. The mean vitamin D level in the PCOS group was 15.45±7.88 ng/ml and in the control group was 12.83±5.76ng/ml. The mean vitamin D levels in the obese and non obese group with PCOS were 16.11±8.9ng/ml and 14.61±6.1ng/ml respectively. Majority of the patients and controls had vitamin D deficiency and there was no difference in the vitamin D levels in PCOS group and controls as well as obese and non obese groups. [Int J Reprod Contracept Obstet Gynecol 2013; 2(3.000): 336-343

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Vitamin D and calcium dysregulation in the polycystic ovarian syndrome

Cited by 171 publications

References 19 publications

The role of vitamin D in metabolic disturbances in polycystic ovary syndrome: a systematic review

The role of vitamin D in metabolic disturbances in polycystic ovary syndrome: a systematic review

Relationship between Vitamin D and Insulin Resistance in Polycystic Ovary Syndrome Women

Comparison of vitamin D levels in obese and non obese patients with polycystic ovarian syndrome in a South Indian population

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