Vitamin D and Cardiovascular Disease: Current Evidence and Future Perspectives

Cosentino, Nicola; Campodonico, Jeness; Milazzo, Valentina; Metrio, Monica De; Brambilla, Marta; Camera, Marina; Marenzi, Giancarlo

doi:10.3390/nu13103603

Cited by 95 publications

(85 citation statements)

References 100 publications

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“…Both nuclear vitamin D receptor (VDR) and the enzyme 25-hydroxyvitamin D3-1αhydroxylase have been identified in various cells of the cardiovascular system, indicating a direct involvement of this hormone group in the initiation and progression of CVD [41]. Importantly, in patients with heart failure, atrial fibrillation, or coronary artery disease vitamin D deficiency was associated with a worse prognosis [42][43][44].…”

Section: Discussionmentioning

confidence: 99%

Small Differences in Vitamin D Levels between Male Cardiac Patients in Different Stages of Coronary Artery Disease

Brkic

Baumgartner

Riss

et al. 2022

JCM

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Less than 20% of patients with sensorineural hearing loss (HL) provided with the Vibrant Soundbridge (VSB) experience a progressive HL and warrant cochlear implantation (CI). The aim of this study was to identify possible predictors of progressive HL prior to VSB implantation. This retrospective study included all consecutive ears with sensorineural HL provided with the VSB between 1998 and 2016. The patient cohort was divided in a study group comprising patients who underwent CI (CI group) after years of VSB usage and those who did not require VSB replacement during the observational time (control group). Pre- and postoperative pure-tone audiometry thresholds were compared among the two groups. Fifteen out of 81 VSB devices (18.5%) required a CI. The CI group had higher preoperative air-conduction (AC) thresholds than the control group (64.3 ± 8.9 dB vs. 56.3 ± 12.9 dB; p = 0.007) at the time of the VSB implantation. On average, the CI group was significantly younger (39.1 ± 12.3 years vs. 52.6 ± 16.2 years; p = 0.003). In conclusion, VSB users with higher preoperative AC thresholds and younger age at the time of VSB implantation might be at risk for progressive HL within the upcoming eight years and need a further CI surgery. Preoperative counseling is particularly advisable in this patient group.

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Section: Discussionmentioning

confidence: 99%

Small Differences in Vitamin D Levels between Male Cardiac Patients in Different Stages of Coronary Artery Disease

Brkic

Baumgartner

Riss

et al. 2022

JCM

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“…3 The effects of vitamin D deficiency on atrial fibrillation (AF) are explained by direct effects on atrial tissue and indirect effects on cardiovascular risk factors. 4 Postoperative atrial fibrillation (PoAF) is an important problem that increases mortality and morbidity rates after cardiac surgery operations. 5 Various studies have been conducted on the relationship between vitamin D and PoAF.…”

Section: Commentarymentioning

confidence: 99%

“…In a study, it was revealed that the risk of hospitalization and mortality increased due to vitamin D deficiency in patients with heart failure 3 . The effects of vitamin D deficiency on atrial fibrillation (AF) are explained by direct effects on atrial tissue and indirect effects on cardiovascular risk factors 4 …”

Section: Commentarymentioning

confidence: 99%

Vitamin D supplementation and postoperative atrial fibrillation

Yavuz

Engin

2022

Journal of Cardiac Surgery

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Vitamin D is an important vitamin that has hormone-like effects in the human body. 1,25-dihydroxy vitamin D (1,25(OH)2 D) is known as the active form of vitamin D. Activated vitamin D can affect cellular proliferation, apoptosis, cellular membrane transport, immune system, and aging through genes. Postoperative atrial fibrillation (PoAF) is an important problem that increases mortality and morbidity rates after cardiac surgery operations. Various studies have been conducted on the relationship between vitamin D and PoAF. Although there are studies in the literature showing that vitamin D supplementation reduces cardiovascular mortality and morbidity in different study types (randomized vs. observational), there are also studies showing that it has no effect on clinical outcomes. Since the subject is atrial fibrillation, the conditions of the study groups such as age, the prevalence of coronary artery disease, degree of hypertension, and lung disease should be analyzed well. On the other hand, vitamin D supplementation should be carefully determined for which patient, for how long, and at what dose.

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“…Vitamin D 3 deficiency or insufficiency is a highly prevalent but often underestimated condition in the general population, especially among the elderly [ 1 , 2 ]. Over the last two decades, several studies have demonstrated a negative impact of vitamin D 3 deficiency on morbidity and mortality in various patient populations with chronic illnesses [ 3 , 4 , 5 , 6 ], and associations between vitamin D 3 deficiency and cardiovascular diseases have been reported (reviewed in [ 7 , 8 ]). By targeting the vitamin D 3 receptor expressed on cardiomyocytes, vitamin D 3 has been found to affect myocardial metabolism with beneficial effects on myocardial dysfunction and cardiac hypertrophy [ 9 , 10 ].…”

Section: Introductionmentioning

confidence: 99%

The Role of Vitamin D3 as an Independent Predicting Marker for One-Year Mortality in Patients with Acute Heart Failure

Thiele

Cornelissen

Florescu

et al. 2022

JCM

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Background: Deficiency in vitamin D3 and its metabolites has been linked to dismal outcomes in patients with chronic diseases, including cardiovascular disease and heart failure (HF). It remains unclear if a vitamin D3 status is a prognostic feature in patients with acute decompensated HF. Methods: We assessed serum levels of 25-OH-vitamin D3 and 1,25-(OH)2-vitamin D3 in 139 patients with acute HF who had been admitted to the intermediate care unit of a maximum care hospital. The follow-up period was one year. After exclusion of patients with sampling errors and those who were lost to follow-up, 118 patients remained in the final study cohort. Outcome estimates by 25-OH-vitamin D3 and 1,25-(OH)2-vitamin D3 levels were compared to the Seattle Heart Failure (SHF) Model. Results: More than two-thirds (79.7%) of the patients showed inadequate 25-OH-vitamin D3 levels (i.e., <30 ng/mL) upon admission. Low levels of 1,25-(OH)2-vitamin D3 (i.e., <19.9 pg/mL) were observed in 16.1% of patients. Of the 118 HF patients, 22 (19%) died during the following 12 months. There were no differences in vitamin D3 levels between patients who died and those who survived, neither in 25-OH-vitamin D3 (23.37 ± 19.14 ng/mL vs. 19.11 ± 12.25 ng/mL; p = 0.19) nor in 1,25-(OH)2-vitamin D3 levels (31.10 ± 19.75 ng/mL vs. 38.25 ± 15.73 ng/mL; p = 0.02); therefore, vitamin D3 levels alone did not predict one-year survival (AUC [25-OH-vitamin D3] 0.50; 95% CI 0.34–0.65; AUC [1,25-(OH)2-vitamin D3] 0.62; 95% CI 0.48–0.76). Moreover, whilst the SHF model exhibited acceptable discriminatory ability for predicting one-year mortality (AUC 0.79; 95% CI 0.66–0.91), adding vitamin D levels on admission to the SHF score did not improve its discriminatory value. Conclusion: Our data do not support the use of vitamin D3 screening in patients admitted with acute decompensated HF to aid prognostication.

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Vitamin D and Cardiovascular Disease: Current Evidence and Future Perspectives

Cited by 95 publications

References 100 publications

Small Differences in Vitamin D Levels between Male Cardiac Patients in Different Stages of Coronary Artery Disease

Small Differences in Vitamin D Levels between Male Cardiac Patients in Different Stages of Coronary Artery Disease

Vitamin D supplementation and postoperative atrial fibrillation

The Role of Vitamin D3 as an Independent Predicting Marker for One-Year Mortality in Patients with Acute Heart Failure

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