Vitamin D and Chronic Diseases

Abstract

Vitamin D is one of the essential nutrients to sustain the human health. As a member of the steroid hormone family, it has a classic role in regulating metabolism of calcium and a non-classic role in affecting cell proliferation and differentiation. Epidemiological studies have shown that 25OHD deficiency is closely associated with common chronic diseases such as bone metabolic disorders, tumors, cardiovascular diseases, and diabetes. 25OHD deficiency is also a risk factor for neuropsychiatric disorders and autoimmune diseases. 25OHD deficiency is highly prevalent in the world. It is therefore necessary to know the adverse health effects of 25OHD deficiency, and to design interventions and early treatments for those who are likely to have low levels of 25OHD.

Electrochemical Determination of Vitamin D3 in Pharmaceutical Products by Using Boron Doped Diamond Electrode

“…Clinical applications of the active form of vitamin D 3 are associated with treatment of renal osteodystrophy and osteoporosis, psoriasis, and secondary hyperparathyroidism [12]. However, since it is evident that vitamin D deficiency is associated with many other chronic diseases such as cancer, cardiovascular, neuropsychiatric and autoimmune diseases [3][4][5][6]13], more data are necessary to clearly prove eventual beneficial effect of vitamin D supplementation in those cases.…”

Reduced vitamin D receptor (VDR) expression and plasma vitamin D levels are associated with aging‐related prostate lesions

“…Although vitamin D is recognized by its classic role in bone health, a growing body of evidence has linked its deficiency, a re‐emerging global health problem, with increased risk for several diseases including prostate cancer . Prostate cancer is one of the most commonly diagnosed neoplasms and the fifth leading cause of cancer death worldwide …”

Gene-environment interactions as the basis of health formation

“…2), а эпидемиологические данные подтвердили значимость дефицита витамина D в развитии опухолей, патологий сердечно-сосудистой системы, аутоиммунных заболева-ний, диабета, нейропсихических расстройств и др. [18]. Полиморфные варианты гена RBP4, кодирующего рети-нол-связывающий белок, оказались информативны для оценки риска развития атеросклероза, других заболе-ваний сердечно-сосудистой системы и сахарного диабе-та 2-го типа [19].…”