Vitamin D and colorectal cancer – A practical review of the literature

Peixoto, Renata D’Alpino; Oliveira, Leandro Jonata de Carvalho; Passarini, Thaís; Andrade, Alexander de; Diniz, Paulo Henrique Costa; Prolla, Gabriel; Amorim, Larissa Costa; Gil, Mariana; Lino, Flora; Garicochea, Bernardo; Jácome, Alexandre A.; Ng, Kimmie

doi:10.1016/j.ctarc.2022.100616

Cited by 15 publications

(9 citation statements)

References 89 publications

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“…The higher the CYP24A1 polymorphism, the lower the activated vitamin D. 20 Calcitriol binds to VDR and produces transcriptional activation and repression of target genes, causing increased apoptosis, decreased angiogenesis and cell differentiation so that disruption of its synthesis can increase the risk of CRC. 21 Calcitriol inhibits proliferation, migration, invasiveness and angiogenesis of CRC cells, increases differentiation, and makes these cells sensitive to apoptosis. Calcitriol reduces the protumoral effect of CRC-associated fibroblasts.…”

Section: Discussionmentioning

confidence: 99%

The Association Between CYP24A1 rs4809957 Gene Polymorphism and Grade of Colorectal Cancer at Prof. Dr. I G.N.G Ngoerah Hospital in Bali

Puspitasari,

Dewi,

Artini

et al. 2023

International Journal of Scientific Advances

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Introduction: Colorectal cancer (CRC) is a malignancy in the large intestine, including the colon and rectum. One of the pathogenesis of CRC is the molecular pathway. This study aimed to evaluate the association between the CYP24A1 rs4809957 gene polymorphism and the histopathological grade of CRC patients at Prof. Dr. I G.N.G. Ngoerah Hospital in 2018-2019. Methods: This research was an observational analytic study with a cross-sectional design. This study used 34 samples of stored biological material from CRC tissue. CYP24A1 polymorphism (rs4809957) was identified using qPCR. Results: The results showed that the mean ± SD of the patient’s age was 61.09 ± 11.79 years. A total of 18 patients (52.9%) of the patient sample were male, and 16 patients (47.1%) were female. The histopathological grade of CRC in this study consisted of 30 samples (88.2%) of low grade and 4 (11.8%) of high grade. There were 21 patients (61.8%) who had a history of smoking. In addition, 20 patients (58.8%) had a history of consuming alcoholic beverages. This study’s CYP24A1 rs4809957 gene polymorphism comprised the AA+AG genotype in 23 samples (67.6%) and GG in 11 (32.4%). There was no significant association between the CYP24A1 rs4809957 gene polymorphism and the histopathological grade of CRC with a p-value = 0.580 and PR (95%CI) = 2.33 (0.83 – 19.42). Conclusion: This study concluded that there was no significant association between the CYP24A1 rs4809957 gene polymorphism and the histopathological grade of CRC patients.

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Section: Discussionmentioning

confidence: 99%

The Association Between CYP24A1 rs4809957 Gene Polymorphism and Grade of Colorectal Cancer at Prof. Dr. I G.N.G Ngoerah Hospital in Bali

Puspitasari,

Dewi,

Artini

et al. 2023

International Journal of Scientific Advances

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“…3 1,25-D inhibits vascular endothelial growth factor (VEGF) production and early angiogenesis in TSC-associated tumors 1,25 D causes transcriptional changes by binding to the intracellular vitamin D receptor (VDR). This binding forms a complex that interacts with specific DNA sequences called vitamin D-response elements (VDREs) located within the promoter regions of target genes (14).…”

Section: Need For An Alternative or Supportive Drug To Mtori In Pedia...mentioning

confidence: 99%

Vitamin D in tuberous sclerosis complex-associated tumors

Nobutoki

2024

Front. Pediatr.

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Mammalian target of rapamycin inhibitors (mTORi) have been used to treat pediatric tuberous sclerosis complex (TSC)-associated tumors, particularly in cases with contraindications to surgery or difficulties in complete tumor resection. However, some patients experience side effects and tumor regression after discontinuation of the treatment. Therefore, there is an urgent need to develop drugs that can be used in combination with mTORi to increase their efficacy and minimize their side effects. 1,25-Dihydroxyvitamin D3 (1,25-D), which has anticancer properties, may be a promising candidate for adjuvant or alternative therapy because TSC and cancer cells share common mechanisms, including angiogenesis, cell growth, and proliferation. Vitamin D receptor-mediated signaling can be epigenetically modified and plays an important role in susceptibility to 1,25-D. Therefore, vitamin D signaling may be a promising drug target, and in vitro studies are required to evaluate the efficacy of 1,25-D in TSC-associated tumors, brain development, and core symptoms of psychiatric disorders.

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“…It has been reported that higher serum levels of 25(OH)D 3 at diagnosis have been linked to longer survival in cancer patients [ 41 ]. A recent review [ 42 ] investigating the results of the pivotal RCTs, which addressed the relationship between vitamin D supplementation and the clinical outcomes in colorectal cancer patients, supported the conclusion that even though additional clinical trials are needed to clarify the effect of vitamin D supplementation on the morbidity, mortality, recurrence, and progression of colorectal cancer, lower serum 25(OH)D 3 levels are inversely associated with colorectal cancer. Moreover, a metanalysis by Voutsadakis [ 43 ] showed that low 25(OH)D 3 levels were associated with breast cancer at diagnosis.…”

Section: Vitamin D Deficiency and Related Disordersmentioning

confidence: 99%

Calcifediol: Why, When, How Much?

Donati

Marini²,

Giusti

et al. 2023

Pharmaceuticals

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Vitamin D deficiency is a constantly growing health problem worldwide. Adults affected with hypovitaminosis D could experience negative consequences on their musculoskeletal system and extra-skeletal health. In fact, an optimal vitamin D status is essential to ensure the correct bone, calcium, and phosphate homeostasis. To improve vitamin D status, it is important to not only increase the intake of food fortified with vitamin D, but also to administer vitamin D supplementation when required. Vitamin D3 (cholecalciferol) is the most widely used supplement. In recent years, the administration of calcifediol (25(OH)D3), the direct precursor of the biologically active form of vitamin D3, as oral vitamin D supplementation has progressively grown. Here, we report the potential medical benefits of some peculiar biological actions of calcifediol, discussing the possible specific clinical scenarios in which the oral intake of calcifediol could be most effective to restore the correct serum levels of 25(OH)D3. In summary, the aim of this review is to provide insights into calcifediol-related rapid non-genomic responses and the possible use of this vitamin D metabolite as a supplement for the treatment of people with a higher risk of hypovitaminosis D.

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Vitamin D and colorectal cancer – A practical review of the literature

Cited by 15 publications

References 89 publications

The Association Between CYP24A1 rs4809957 Gene Polymorphism and Grade of Colorectal Cancer at Prof. Dr. I G.N.G Ngoerah Hospital in Bali

The Association Between CYP24A1 rs4809957 Gene Polymorphism and Grade of Colorectal Cancer at Prof. Dr. I G.N.G Ngoerah Hospital in Bali

Vitamin D in tuberous sclerosis complex-associated tumors

Calcifediol: Why, When, How Much?

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