Vitamin D and diabetes: the devil is in the D-tails

Mathieu, Chantal

doi:10.1007/s00125-010-1791-z

Cited by 15 publications

(5 citation statements)

References 10 publications

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“…The T1D data also support vitamin D as sunlight’s protective signal transducer ( 6 , 104 , 105 ). The EURODIAB study correlated vitamin D 3 supplementation in infancy with decreased T1D risk (odds ratio 0.67) ( 106 ), a finding that has been replicated ( 107 ).…”

Section: Genes Sunlight Vitamin D and T Lymphocytesmentioning

confidence: 60%

Vitamin D Actions on CD4+ T Cells in Autoimmune Disease

et al. 2015

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This review summarizes and integrates research on vitamin D and CD4+ T-lymphocyte biology to develop new mechanistic insights into the molecular etiology of autoimmune disease. A deep understanding of molecular mechanisms relevant to gene–environment interactions is needed to deliver etiology-based autoimmune disease prevention and treatment strategies. Evidence linking sunlight, vitamin D, and the risk of multiple sclerosis and type 1 diabetes is summarized to develop the thesis that vitamin D is the environmental factor that most strongly influences autoimmune disease development. Evidence for CD4+ T-cell involvement in autoimmune disease pathogenesis and for paracrine calcitriol signaling to CD4+ T lymphocytes is summarized to support the thesis that calcitriol is sunlight’s main protective signal transducer in autoimmune disease risk. Animal modeling and human mechanistic data are summarized to support the view that vitamin D probably influences thymic negative selection, effector Th1 and Th17 pathogenesis and responsiveness to extrinsic cell death signals, FoxP3+CD4+ T-regulatory cell and CD4+ T-regulatory cell type 1 (Tr1) cell functions, and a Th1–Tr1 switch. The proposed Th1–Tr1 switch appears to bridge two stable, self-reinforcing immune states, pro- and anti-inflammatory, each with a characteristic gene regulatory network. The bi-stable switch would enable T cells to integrate signals from pathogens, hormones, cell–cell interactions, and soluble mediators and respond in a biologically appropriate manner. Finally, unanswered questions and potentially informative future research directions are highlighted to speed delivery of etiology-based strategies to reduce autoimmune disease.

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Section: Genes Sunlight Vitamin D and T Lymphocytesmentioning

confidence: 60%

Vitamin D Actions on CD4+ T Cells in Autoimmune Disease

et al. 2015

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“…Previous studies have suggested improved control of anemia in dialysis patients treated with active forms of VD or nutritional VD precursors [10–13]. Moreover, many tissues possess CYP27B1 and are able to activate VD [21]. Recent findings indicated that VD is activated outside the kidney [22].…”

Section: Discussionmentioning

confidence: 99%

Plasma 25-Hydroxyvitamin D Is Independently Associated with Hemoglobin Concentration in Male Subjects with Type 2 Diabetes Mellitus

Meguro

Tomita

Katsuki

et al. 2011

International Journal of Endocrinology

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Introduction. It was reported that 25-hydroxyvitamin D level was independently associated with anemia in chronic kidney diseases, but the relation between vitamin D and anemia in diabetes mellitus is not still certain. We analyzed the relation between plasma 25-hydroxyvitamin D level and hemoglobin concentration. Materials and Methods. A cross-sectional study in male patients with type 2 diabetes was performed. Correlation coefficients and standardized partial regression coefficient for the hemoglobin concentration were evaluated. Results. Hemoglobin concentration was positively correlated with body mass index, HbA1c, estimated glomerular filtration rate, cholinesterase, and 25-hydroxyvitamin D level and negatively correlated with age, duration of diabetes mellitus, serum creatinine, and urinary albumin creatinine ratio. Multiple regression analysis revealed the independent relation of 25-hydroxyvitamin D to hemoglobin concentration. Conclusions. Plasma circulating form of vitamin D is significantly associated with hemoglobin concentration in diabetes mellitus independent of the clinical markers for kidney function or nutrition.

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“…They are known to cause autosomal recessive vitamin D–dependent rickets type 1 (VDDR1; OMIM [Online Mendelian Inheritance in Man database] 264700). A role for vitamin D in autoimmunity is well known, and GWASs have implicated common variants near the CYP27B1 gene in MS, and with the same direction of effect in other autoimmune diseases, including type 1 diabetes (T1D) and autoimmune thyroid disease (AITD) …”

mentioning

confidence: 99%

No evidence for a role of rare CYP27B1 functional variations in multiple sclerosis

Barizzone

Pauwels

Luciano

et al. 2013

Annals of Neurology

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Association studies have implicated common variants in the 12q14.1 region containing CYP27B1 in multiple sclerosis (MS). Rare CYP27B1 mutations cause autosomal recessive vitamin D-dependent rickets type 1, and it has recently been reported that heterozygous CYP27B1 mutations are associated with increased MS susceptibility and lower active vitamin D levels. By sequencing CYP27B1 in 134 multiplex families and genotyping the most common variant R389H in 2,608 MS patients and 1,987 controls from Italy and Belgium (a total of 4,729 individuals), we were unable to replicate these observations. These results provide evidence against a major role for CYP27B1 mutations in MS.

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Vitamin D and diabetes: the devil is in the D-tails

Cited by 15 publications

References 10 publications

Vitamin D Actions on CD4+ T Cells in Autoimmune Disease

Vitamin D Actions on CD4+ T Cells in Autoimmune Disease

Plasma 25-Hydroxyvitamin D Is Independently Associated with Hemoglobin Concentration in Male Subjects with Type 2 Diabetes Mellitus

No evidence for a role of rare CYP27B1 functional variations in multiple sclerosis

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