Vitamin D and Diabetic Retinopathy

Antunica, Antonela Gverović; Znaor, Ljubo; Ivanković, Mira; Puzović, Velibor; Marković, Irena; Kaštelan, Snježana

doi:10.3390/ijms241512014

Cited by 8 publications

(2 citation statements)

References 66 publications

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“…An abnormal production of reactive oxygen species and chronic inflammation are credited as significant factors contributing to the development of diabetic retinopathy (DR) [ 52 ]. A low cholecalciferol serum concentration heightens the risk of acquiring DR in people suffering from type 2 diabetes mellitus [ 53 ].…”

Section: Diabetic Retinopathy (Dr) and Diabetic Macular Edema (Dme)mentioning

confidence: 99%

The Role of Vitamin D3 in Ocular Diseases

Mrugacz,

Pieńczykowska,

Bryl

2024

Nutrients

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Vitamin D3 plays a vital role in numerous physiological processes within the human body, including having a positive effect on eye health. It is renowned for its immunomodulatory, anti-inflammatory, antioxidant, and angiogenic properties. Its deficiency is evolving into a significant global challenge. In order to explain the connection between vitamin D3 and various ocular diseases, 84 relevant studies, mainly from the PubMed database, published in English between 1999 and 2024 were analyzed. Ocular tissues can activate and regulate vitamin D levels, which emphasizes the significance of this nutrient in maintaining eye homeostasis. While there is suggestive evidence for a probable association between vitamin D3 and ocular health, more robust research is needed to establish causation and inform clinical guidelines.

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Section: Diabetic Retinopathy (Dr) and Diabetic Macular Edema (Dme)mentioning

confidence: 99%

The Role of Vitamin D3 in Ocular Diseases

Mrugacz,

Pieńczykowska,

Bryl

2024

Nutrients

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“…Fat-soluble vitamin D (or "D hormone") consists of a mixture of vitamin D2 (ergocalciferol) and D3 (cholecalciferol) [153]. The known sources of the vitamin are cereals, mushrooms, various fish (salmon, sardine, herring, mackerel, cod liver oil, etc.…”

Section: Nutrition Supplementationmentioning

confidence: 99%

Complementary Approaches to Retinal Health Focusing on Diabetic Retinopathy

Rák,

Kovács-Valasek,

Pöstyéni

et al. 2023

Cells

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Diabetes mellitus affects carbohydrate homeostasis but also influences fat and protein metabolism. Due to ophthalmic complications, it is a leading cause of blindness worldwide. The molecular pathology reveals that nuclear factor kappa B (NFκB) has a central role in the progression of diabetic retinopathy, sharing this signaling pathway with another major retinal disorder, glaucoma. Therefore, new therapeutic approaches can be elaborated to decelerate the ever-emerging “epidemics” of diabetic retinopathy and glaucoma targeting this critical node. In our review, we emphasize the role of an improvement of lifestyle in its prevention as well as the use of phytomedicals associated with evidence-based protocols. A balanced personalized therapy requires an integrative approach to be more successful for prevention and early treatment.

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Research trends in the relationship between vitamin D and type 2 diabetes mellitus: a 20-year bibliometric and visualization analysis

Xu,

Shao,

Qiao

et al. 2024

Front. Endocrinol.

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IntroductionVitamin D has a significant correlation with type 2 diabetes. Insufficient levels of vitamin D can cause insulin resistance, which impairs the ability of cells to respond to insulin and worsens the progression of diseases. Furthermore, vitamin D has the potential to enhance the release of insulin, enhance the regulation of blood sugar levels, and reduce the glycemic index. Research has indicated that insufficient levels of vitamin D may elevate the likelihood of experiencing complications related to type 2 diabetes, including cardiovascular disease and neuropathy. This study employed bibliometric analysis to investigate recent advancements in research about the relationship between vitamin D and type 2 diabetes.MethodsWe searched for articles on the topic of vitamin D and type 2 diabetes published between January 1, 2004, and December 31, 2023. The search was performed on February 20, 2024, using the Web of Science Core Collection (WoSCC). Utilizing VOSviewer and CiteSpace, we conducted bibliometric analysis and visualization.ResultsA comprehensive study was conducted on a total of 1362 papers pertaining to the relationship between vitamin D and type 2 diabetes. The United States had the biggest number of publications and the highest effect among these articles. Within the top 10 most published journals, the journal “DIABETES CARE” has the highest H-index, indicating its significant influence in this field of study. Currently, there is an extensive body of research on the supplementation of vitamin D for the improvement of type 2 diabetes and prevention of complications in type 2 diabetes, as well as its related mechanisms. Research related to bone turnover and peripheral neuropathy represents a promising area for future studies.ConclusionOverall, bibliometrics may assist researchers in comprehending the trajectory, significant themes, and scholarly influence of the field concerning vitamin D and type 2 diabetes. This, in turn, offers substantial backing for future studies that delve further into the subject matter.

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Vitamin D and Diabetic Retinopathy

Cited by 8 publications

References 66 publications

The Role of Vitamin D3 in Ocular Diseases

The Role of Vitamin D3 in Ocular Diseases

Complementary Approaches to Retinal Health Focusing on Diabetic Retinopathy

Research trends in the relationship between vitamin D and type 2 diabetes mellitus: a 20-year bibliometric and visualization analysis

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