Vitamin D and Gastric Cancer: A Ray of Sunshine?

Shah, Suchitra; Iqbal, Zafar; Alharbi, Mohammed G; Kalra, Harjeevan S; Suri, Megha; Soni, Nitin; Okpaleke, Nkiruka; Yadav, Shikha; Hamid, Pousette

doi:10.7759/cureus.18275

Cited by 6 publications

(7 citation statements)

References 48 publications

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“…UVB radiation, which promotes vitamin D synthesis in the skin, was found to reduce the incidence and mortality rate in patients with gastric cancer with an adequate serum vitamin D level related to a better survival rate. Also, the polymorphisms in the vitamin D receptor gene were found to be related to an increased risk of gastric cancer [35]. Vitamin D may modulate the expression of some miRNAs that are deregulated in gastric cancer cells.…”

Section: Discussionmentioning

confidence: 99%

Vitamin D—The Nutritional Status of Post-Gastrectomy Gastric Cancer Patients—Systematic Review

et al. 2022

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Gastric cancer is a malignant neoplasm of the gastrointestinal tract, with one of the standard treatment methods remaining gastrectomy. The authors conducted a systemic review of the Medline and Embase databases concerning the serum vitamin D level in post-gastrectomy gastric cancer patients, regarding all articles published until 22 May 2022 according to the PRISMA guidelines. 18 studies with a total number of 908 gastric cancer survivors were included in the analysis. The initial rate of vitamin D deficiency in gastric cancer patients undergoing gastrectomy appears to be similar to the global population deficiency. In post-gastrectomy survivors, the level of 25(OH)D may remain stable or decrease, while the level of 1, 25(OH)2D remains normal. Supplementation with vitamin D results in an improvement in its serum concentration and positively affects bone mineral density, which is gradually reduced in post-gastrectomy survivors. Combining vitamin D supplementation with calcium and bisphosphonates enables us to obtain better results than vitamin D and calcium only. The type of surgery influences the level of serum vitamin D and its metabolites, with total or partial gastrectomy and maintenance of the duodenal food passage remaining the most important factors. There is a strong need for randomized, controlled trials that would investigate this matter in the future.

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Section: Discussionmentioning

confidence: 99%

Vitamin D—The Nutritional Status of Post-Gastrectomy Gastric Cancer Patients—Systematic Review

et al. 2022

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“…McCullough ML et al [17] As one of the most aggressive malignant tumors, gastric cancer (GC) is currently the third leading cause of death in the world. Although recent progress has been made in the study of gastric cancer, it is most often diagnosed in the late stage, and the treatment is limited, resulting in a poor prognosis and low survival rate [19]. Related studies have proven that vitamin D can promote the apoptosis of gastric cancer cells and prevent the malignant transformation of gastric mucosal epithelial cells.…”

Section: Introductionmentioning

confidence: 99%

Real-world data of the effects of serum 25(OH)D and plasma fatty acids on breast and stomach tumors：A cross-sectional study

Zhong

2023

Preprint

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Objective To investigate the correlation between serum 25(OH)D and plasma fatty acid levels and the clinical stage, tumor markers, histopathology and lymph node metastasis of patients with solid tumors, so as to further understand the potential impact of vitamin D and fatty acids on breast and stomach tumors. Methods A real world study, cross sectional study was conducted on patients with breast malignant tumor, benign breast tumor and gastric malignant tumor who were treated in Liaoning Cancer Hospital & Institute, from April 2020 to May 2021. The general clinical data of the patients, the laboratory data of serum vitamin D and plasma fatty acid levels were collected, and the effects of serum vitamin D and plasma fatty acid levels on solid tumors were statistically analyzed. Results The serum 25 (OH) D level and plasma fatty acid level of tumor patients were abnormal compared with their corresponding normal standard values. The expression level of 25 (OH) D in breast malignant tumors was significantly different according to tumor stage and molecular classification (P < 0.05), indicating that the pathological features such as tumor stage and molecular classification of breast cancer may be related to the expression level of serum 25 (OH) D. Multivariate analysis showed that carcinoembryonic antigen was a significant difference between breast malignant tumors and benign breast tumors, and 25 (OH) D and eicosapentaenoic acid (DPA) were significant differences between breast malignant tumors and benign breast tumors (P < 0.1). Conclusion Vitamin D deficiency and deficiency are common in tumor patients. The level of serum 25 (OH) D is correlated with the course of breast tumor, tumor stage and molecular classification. 25 (OH) D is a significant difference between breast malignant tumor and breast benign tumor. There is abnormal level of plasma free fatty acid in tumor patients. DPA is a significant difference between breast malignant tumor and benign breast tumor, which may be related to the pathological degree of breast tumor.

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“…Gastric cancer is the third leading cause of cancer-related mortality worldwide. 1,2 It has a high incidence and mortality rate, ranking fifth and third, respectively, according to the latest GLOBOCAN statistics. 3 However, the lack of early diagnosis methods and the aggressive nature of GC contribute to poor outcomes for patients with advanced disease.…”

Section: Introductionmentioning

confidence: 99%

“…Gastric cancer is the third leading cause of cancer‐related mortality worldwide 1,2 . It has a high incidence and mortality rate, ranking fifth and third, respectively, according to the latest GLOBOCAN statistics 3 .…”

Section: Introductionmentioning

confidence: 99%

CircTMEM87A promotes the tumorigenesis of gastric cancer by regulating the miR‐1276/SLC7A11 axis

Dong,

Chen,

Zhao

et al. 2023

J of Gastro and Hepatol

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BackgroundGastric cancer (GC) is a common malignancy with high incidence and mortality, and its pathogenesis involves the regulation of circular RNAs (circRNAs). However, the molecular mechanism of circTMEM87A in GC malignant progression is uncertain.MethodsQuantitative real‐time polymerase chain reaction (qRT‐PCR) was performed to detect the expressions of circTMEM87A, miR‐1276, and solute carrier family 7 membrane 11 (SLC7A11). Western blot was applied to detect protein expression levels of EMT‐related proteins (vimentin and E‐cadherin) and SLC7A11. Cell counting kit‐8 assay (CCK8) and thymidine analog 5‐ethynyl‐2′‐deoxyuridine (EdU) were performed to assess cell proliferation. Apoptosis was investigated using flow cytometry. Transwell assay and wound healing assay were carried out to examine the migration of MKN‐7 and AGS cells. The Cellular ROS Assay Kit, Iron Assay Kit, and GSH/GSSG Ratio Detection Assay Kit were utilized to monitor lipid ROS level, iron level, and GSH/GSSG ratio, respectively. The interaction between miR‐1276 and circTMEM87A or SLC7A11 was investigated using dual‐luciferase reporter assay and RNA immunoprecipitation (RIP) assay. A xenograft mouse model was constructed to explore the function of circTMEM87A in tumor formation in vivo.ResultsCircTMEM87A and SLC7A11 were upregulated, while miR‐1276 was downregulated in GC tissues and cells. Knockdown of circTMEM87A suppressed the proliferation and migration and promoted apoptosis and ferroptosis of GC cells. CircTMEM87A served as a sponge for miR‐1276, and miR‐1276 inhibitor relieved the circTMEM87A knockdown‐induced effects on GC cell phenotypes. Similarly, SLC7A11, a downstream gene of miR‐1276, rescued miR‐1276 overexpression‐induced effects on GC cell function. Furthermore, circTMEM87A knockdown inhibited GC cell tumor phenotypes in vivo.ConclusionCircTMEM87A promoted the proliferation and migration and inhibited apoptosis and ferroptosis of GC cells by increasing SLC7A11 expression through binding to miR‐1276.

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Vitamin D and Gastric Cancer: A Ray of Sunshine?

Cited by 6 publications

References 48 publications

Vitamin D—The Nutritional Status of Post-Gastrectomy Gastric Cancer Patients—Systematic Review

Vitamin D—The Nutritional Status of Post-Gastrectomy Gastric Cancer Patients—Systematic Review

Real-world data of the effects of serum 25(OH)D and plasma fatty acids on breast and stomach tumors：A cross-sectional study

CircTMEM87A promotes the tumorigenesis of gastric cancer by regulating the miR‐1276/SLC7A11 axis

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