Vitamin D and Immune System

Mosaad, Youssef M.; Mostafa, Mohammed Mahmoud; Elwasify, M; Hm, Youssef; Nm, Omar

doi:10.4172/2376-1318.1000151

Cited by 4 publications

(3 citation statements)

References 189 publications

(296 reference statements)

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“…3 Vitamin D plays an important role in the regulation of calcium level and bone metabolism in the body, its active metabolite 1,25(OH)2D (calcitriol) facilitate the innate and adaptive immune systems and triggers effective antimicrobial pathways against bacterial, viral, and fungal pathogens in the cells of the innate immune system. 4 Moreover, it helps for brain development and function, including neuronal differentiation, proliferation, and apoptosis, regulating synaptic plasticity, the ontogeny of the dopaminergic system, immunomodulation, reduces the risk of asthma and reducing oxidative burden. 5 Over 40% of infants’/adults’ skin should be exposed to sunshine daily for twenty minutes in order to synthesize a sufficient amount of 25(OH)D3 or to prevent its deficiency.…”

Section: Introductionmentioning

confidence: 99%

Knowledge and Practice of Infants Exposure to Sunlight Among Lactating Mothers Attending at Yirgalem Hospital, Sidama Regional State

Bezabih¹,

Eshetu²,

Yohanis³

et al. 2021

Clin Med Insights Pediatr

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Background: Exposure to sunlight is vital for the synthesis of vitamin-D and vitamin D plays an important role in growth and bones strength. Therefore, this study aimed to assess the knowledge and practice of infants exposure to sunlight among lactating women. Methods: A cross-sectional study was conducted from May 01 to 30, 2019 among 327 infant coupled lactating mothers attended at Yirgalem General Hospital. An interviewer-administered questionnaire was used to collect relevant data through a convenient sampling technique. Results: A total of 84.7% of respondents exposed infants to sunlight. More than 94% knew the benefit of exposing infants to sunlight. About 20.9%, 25.6%, and 19.9% of mothers exposed infants to sunlight within 15, 16 to 30, and 31 to 45 days of birth, respectively. In addition, 59.9% of respondents exposed infants to sunshine daily and 72.2% exposed without clothing the infants’ body. Moreover, 63.5% of mothers have applied lubricants and overall 54.5% of mothers exposed infants to sunlight in good practice. Unemployed women were 4.7 times more likely (aOR; 95%CI: 4.7; 2.0-11.4) to expose infants to sunlight when compared to those employed, while women whose husbands have at least secondary education level were 5.1 times more likely (aOR; 95%CI: 5.1; 1.6-16.1) to expose infants to sunlight when compared to those unable to read and write. Conclusion: More than 45% and more than one-third of lactating mothers had poor practice and exposed infants to sunlight for inadequate time, respectively. Therefore, the finding indicates a need for awareness creation to increase women’s knowledge and practice toward the exposure of infants to sunlight.

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Section: Introductionmentioning

confidence: 99%

Knowledge and Practice of Infants Exposure to Sunlight Among Lactating Mothers Attending at Yirgalem Hospital, Sidama Regional State

Bezabih¹,

Eshetu²,

Yohanis³

et al. 2021

Clin Med Insights Pediatr

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“…Selain dari fungsi tersebut beberapa penelitian menunjukan bahwa Vitamin D di ternak ataupun manusia mempunyai efek yang besar terhadap sistem kekebalan tubuh. Vitamin D dalam tubuh berpengaruh baik terhadap innnate immunity maupun adaptive immunity (Mosaad 2017). Efek vitamin D dalam sistem kekebalan dikarenakan terdapatnya Vitamin D Reseptor (VDR) di hampir semua jaringan termasuk jaringan sel sistem kekebalan.…”

Section: Pendahuluanunclassified

Analisis Pengaruh Suplementasi 25-Hydroxycholecalciferol terhadap Performa Pertumbuhan Ayam Broiler dalam Kondisi Komersial di Jawa Barat, Indonesia

Mauluddin,

Hermana,

Jayanegara

et al. 2023

JINTP

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A large-scale commercial production trial was conducted to evaluate the effect of supplemental 25-hydroxycholecalciferol (25(OH)D3) on the growth performance of broilers. A total of 100,000 day-old mixed-sex Cobb 500 broilers were allocated equally to 20 farms with 5000 broilers each. Two experimental diets were prepared: 1) Control diet [(3000 IU D3 kg diet-1 + 2760 IU D3 kg diet-1) = total 5760 IU D3 kg diet-1] and 2) Experimental diet [(3000 IU D3 kg diet-1 + 69 mcg 25(OH)D3 kg diet-1 = 2760 IU D3 equivalent kg diet-1) = total 5760 IU D3 kg diet-1]. The design used a randomized block design with Multivariate Analysis of Covariance analysis method The results showed that broilers chickens fed supplemental 25(OH)D3 significantly gained faster, more efficient feed conversion and lower mortality rate from 0 to 14 days when compared to those fed without 25(OH)D3 supplementation. Moreover, the relative growth on the diet supplemented with 25(OH)D3 at 7 days was significantly (p<0.05) greater than that without supplementation. At 14 days to harvest, growth parameters including the Production Efficiency Index of broilers supplemented with 25(OH)D3 were 3-4% better than that of the control diet. Significantly lower mortality rates (p<0.05) were observed in broilers fed 25(OH)D3-supplemented diets compared to unsupplemented diets. It can be concluded of this study demonstrated the positive impact of supplemental 25(OH)D3 on broilers raised under commercial conditions in West Java, Indonesia. Key words: broiler performance, commercial condition, mortality, 25 hydroxycholecalciferol

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“…Unlike, CAMP which only needs occupancy of vitamin D response elements, DEFB4 entails additional habitation of nuclear factor-κB (NF-κB) for transcriptional induction. Nonetheless, vitamin D is central to the generation of these anti-bacterial peptides against infectious agents [34].…”

Section: Innate Immune Systemmentioning

confidence: 99%

Molecular Mechanisms of Vitamin D-Mediated Immunomodulation

Shah,

Alswailmi,

Nawaz

et al. 2021

GMJ

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Ever since discovering the fat-soluble secosteroid vitamin D, an abundance of research has been conducted on the molecular mechanisms for the multiple health benefits of this nutrient. Studies on the beneficial effects of vitamin D supplementation have found appreciable evidence suggesting that it may play a more prime role than initially presumed. Though it has largely been implicated in bone pathophysiology, novel research on vitamin D indicates its fundamental involvement in a wide range of disease processes through its multiple systemic effects, including but not limited to metabolic, cardiovascular, anti-inflammatory, antineoplastic, antioxidant, neuroprotective, and immune actions. Recent work has yielded important mechanistic insights into the functions of vitamin D in mediating immunity. The present work sheds light on the metabolism and immune response mechanisms of vitamin D. Current review is based on a thorough search of the available relevant research findings of the metabolic transformations of vitamin D and the molecular basis of its role in immunity. Apart from its classical mechanistic control of mineral homeostasis, vitamin D has immunomodulatory effects through various mechanisms at both systemic and cellular levels. Disruption of vitamin D reliant molecular pathways in the regulation of immune response can potentially result in the development and/or progression of autoimmune and infective processes. [GMJ.2021;10:e2097]

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Vitamin D and Immune System

Abstract: Vitamin D interaction with immune system is a well-established although it is a non-classical effect of Vitamin D.

Cited by 4 publications

References 189 publications

Knowledge and Practice of Infants Exposure to Sunlight Among Lactating Mothers Attending at Yirgalem Hospital, Sidama Regional State

Knowledge and Practice of Infants Exposure to Sunlight Among Lactating Mothers Attending at Yirgalem Hospital, Sidama Regional State

Analisis Pengaruh Suplementasi 25-Hydroxycholecalciferol terhadap Performa Pertumbuhan Ayam Broiler dalam Kondisi Komersial di Jawa Barat, Indonesia

Molecular Mechanisms of Vitamin D-Mediated Immunomodulation

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