Vitamin D and its Effects on DNA Methylation in Development, Aging, and Disease

Ong, Lawrence; Booth, David R.; Parnell, Grant P

doi:10.1002/mnfr.202000437

Cited by 21 publications

(9 citation statements)

References 79 publications

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“…Several epigenetic effects of VD have been described in a number of models and pathophysiological contexts. These effects include DNA methylation, possibly through modulation of DNA methyltransferase and/or DNA demethylase expression [ 52 ]. VD can also regulate histone acetylation via activation of histone acetyltransferases and histone deacetylases, but also histone methylation and demethylation, thus modulating chromatin accessibility to transcription factors [ 53 ].…”

Section: Metabolism Of the Vitamin Dmentioning

confidence: 99%

Vitamin D and Obesity/Adiposity—A Brief Overview of Recent Studies

et al. 2022

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Observational studies classically find an inverse relationship between human plasma 25-hydroxyvitamin D concentration and obesity. However, interventional and genetic studies have failed to provide clear conclusions on the causal effect of vitamin D on obesity/adiposity. Likewise, vitamin D supplementation in obese rodents has mostly failed to improve obesity parameters, whereas several lines of evidence in rodents and prospective studies in humans point to a preventive effect of vitamin D supplementation on the onset of obesity. Recent studies investigating the impact of maternal vitamin D deficiency in women and in rodent models on adipose tissue biology programming in offspring further support a preventive metabolically driven effect of vitamin D sufficiency. The aim of this review is to summarize the state of the knowledge on the relationship between vitamin D and obesity/adiposity in humans and in rodents and the impact of maternal vitamin D deficiency on the metabolic trajectory of the offspring.

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Section: Metabolism Of the Vitamin Dmentioning

confidence: 99%

Vitamin D and Obesity/Adiposity—A Brief Overview of Recent Studies

et al. 2022

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“…Despite the exact relationship between diet and the epigenome remains unclear, several studies reported an association between epigenetic modifications and dietary depletion or supplementation (1,(42)(43)(44)(45)(46)(47)(48).…”

Section: Discussionmentioning

confidence: 99%

Sperm DNA Methylation at Metabolism-Related Genes in Vegan Subjects

et al. 2021

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ObjectiveTo investigate if epigenome of sperm cells could be dynamically affected by nutrition.Design and MethodsWe assessed 40 healthy volunteers with different dietary habits and collected their demographic characteristics, as well as clinical and anthropometric parameters. We compared methylation profiles in sperm quantified by bisulfite pyrosequencing, at promoter-associated CpG sites of genes involved in metabolism including fat mass and obesity-associated (FTO) and melanocortin-4 receptor (MC4R) from six vegans and 34 omnivores. In addition, the FTO rs9939609 (T>A) was genotyped.ResultsHigher DNA methylation levels were detected in the sperm of vegan at FTO gene CpG1 (p=0.02), CpG2 (p=0.001), CpG3 (p=0.004), and CpG4 (p=0.003) sites and at MC4R-CpG2 site [p=0.016] as compared to sperm of omnivores. This association was not related to FTO genotype.ConclusionsAlthough limited by the small number of investigated cases, our data provide insight into the role of diet on sperm DNA methylation in genes involved in metabolism.

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“…The genomic effect of vitamin D through VDR receptors is thought to be effective in the pathogenesis of health and diseases such as cancer, metabolic syndrome, obesity, diabetes, skin diseases, immunity, inflammation, and organ transplantation-related complications [4]. In addition to these genomic effects of Vit D, it is also known to have epigenetic effects by activating signaling pathways, DNA methylation and histone acetylation [5].…”

Section: Introductionmentioning

confidence: 99%

The relations of vitamin D receptor gene polymorphisms with risk of obesity, metabolic syndrome, hepatostetosis in Turkish children

Özhan

BİLGİHAN²,

Cetin

et al. 2023

Pam Tıp Derg

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Purpose: The aim of study was to determine the relation of vitamin D receptor gene (VDR) polymorphisms of TaqI (rs731236), ApaI (rs7975232), BsmI (rs1544410), FokI (rs10735810) with the risk of obesity, metabolic syndrome and hepatosteatosis in children.Materials and methods: 130 obese and 130 healthy children of age range between 10-16 years included in this study. Anthropometric measurements, biochemical evaluations and abdominal USG of all children were done. Obese and healty children were analyzed for the most common polymorphisms of the VDR gene by restriction fragment length polymorphism’s technique. The diagnosis of metabolic syndrome was made using the International Diabetes Federation criteria.Results: Genotypic distribution of BsmI, FokI, and TaqI polymorphism were found statistically different between obese patients and control group, but genotypic distribution of all studied polymorphisms were not found statistically different in obese patients with metabolic syndrome or hepatosteotosis. Conclusion: BsmI polymorphism (rs1544410) was found to have a significant positive effect on the development of obesity, metabolic syndrome and hepatosteatosis. Children who carry risk factors for childhood obesity could be screened before the development of obesity and associated metabolic complications using the BsmI polymorphism of the VDR gene.

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Vitamin D and its Effects on DNA Methylation in Development, Aging, and Disease

Cited by 21 publications

References 79 publications

Vitamin D and Obesity/Adiposity—A Brief Overview of Recent Studies

Vitamin D and Obesity/Adiposity—A Brief Overview of Recent Studies

Sperm DNA Methylation at Metabolism-Related Genes in Vegan Subjects

The relations of vitamin D receptor gene polymorphisms with risk of obesity, metabolic syndrome, hepatostetosis in Turkish children

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