Vitamin D and Its Relationship with Breast Cancer: An Evidence Based Practice Paper

Obaidi, Jawad; Musallam, Eyad; Alghzawi, Hamzah; Azzeghaiby, Saleh Nasser; Alzoghaibi, Ibrahim

doi:10.5539/gjhs.v7n1p261

Cited by 12 publications

(8 citation statements)

References 12 publications

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“…The topic of vitamin D synthesis, deficiency, and sufficiency has been the subject of a vast number of publications, including several extensive reviews in part relied upon in this section (Hilger et al, 2014;Hosseinnezhad & Holick, 2013;Obaidi et al, 2014;Wacker & Holick, 2013a,b). The term ''vitamin D'' is somewhat nonspecific, referring in common usage to either ergocalciferol (vitamin D2), which is normally derived from diet, cholecalciferol (vitamin D3), which is generated by endogenous natural synthesis, and/or 25-hydroxyvitamin D (25(OH)D3), the form clinically assessed to determine adequacy of vitamin D status.…”

Section: Daytime Sunlight Vitamin D Health and Well-beingmentioning

confidence: 99%

“…As earlier discussed, increased incidence of BC is reported in women employed in night and rotating shift work as well as those who reside in community and home environments rich in ALAN. However, risk of BC (Goodwin et al, 2009;Imtiaz & Siddiqui, 2014;John et al, 1999;Obaidi et al, 2014;Ordóñ ez Mena & Brenner, 2014;Rose et al, 2013) and other cancers (Wacker & Holick, 2013a) is also known to be vitamin D status-dependent. Meta-analysis of reported findings from 4100 countries reveals an inverse relationship between incident solar UV-B irradiation and incidence of several cancers of both men and women -bladder, colorectal, esophageal, gastric, lung, pancreatic, rectal, renal, and Hodgkin's and non-Hodgkin's lymphomaand specifically in women -breast, cervical, endometrial, ovarian, and vulvar cancers (Grant, 2012).…”

Section: Daytime Sunlight Vitamin D Health and Well-beingmentioning

confidence: 99%

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Nocturnal light pollution and underexposure to daytime sunlight: Complementary mechanisms of circadian disruption and related diseases

Smolensky

Sackett-Lundeen²,

Portaluppi

2015

Chronobiology International

112

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Routine exposure to artificial light at night (ALAN) in work, home, and community settings is linked with increased risk of breast and prostate cancer (BC, PC) in normally sighted women and men, the hypothesized biological rhythm mechanisms being frequent nocturnal melatonin synthesis suppression, circadian time structure (CTS) desynchronization, and sleep/wake cycle disruption with sleep deprivation. ALAN-induced perturbation of the CTS melatonin synchronizer signal is communicated maternally at the very onset of life and after birth via breast or artificial formula feedings. Nighttime use of personal computers, mobile phones, electronic tablets, televisions, and the like--now epidemic in adolescents and adults and highly prevalent in pre-school and school-aged children--is a new source of ALAN. However, ALAN exposure occurs concomitantly with almost complete absence of daytime sunlight, whose blue-violet (446-484 nm λ) spectrum synchronizes the CTS and whose UV-B (290-315 nm λ) spectrum stimulates vitamin D synthesis. Under natural conditions and clear skies, day/night and annual cycles of UV-B irradiation drive corresponding periodicities in vitamin D synthesis and numerous bioprocesses regulated by active metabolites augment and strengthen the biological time structure. Vitamin D insufficiency and deficiency are widespread in children and adults in developed and developing countries as a consequence of inadequate sunlight exposure. Past epidemiologic studies have focused either on exposure to too little daytime UV-B or too much ALAN, respectively, on vitamin D deficiency/insufficiency or melatonin suppression in relation to risk of cancer and other, e.g., psychiatric, hypertensive, cardiac, and vascular, so-called, diseases of civilization. The observed elevated incidence of medical conditions the two are alleged to influence through many complementary bioprocesses of cells, tissues, and organs led us to examine effects of the totality of the artificial light environment in which humans reside today. Never have chronobiologic or epidemiologic investigations comprehensively researched the potentially deleterious consequences of the combination of suppressed vitamin D plus melatonin synthesis due to life in today's man-made artificial light environment, which in our opinion is long overdue.

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Section: Daytime Sunlight Vitamin D Health and Well-beingmentioning

confidence: 99%

Section: Daytime Sunlight Vitamin D Health and Well-beingmentioning

confidence: 99%

Nocturnal light pollution and underexposure to daytime sunlight: Complementary mechanisms of circadian disruption and related diseases

Smolensky

Sackett-Lundeen²,

Portaluppi

2015

Chronobiology International

112

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“…Vitamin D (25-hydroxyvitamin D) deficiency has been known as a worrying public health problem for its association with musculoskeletal, immune system, cardiovascular and mental health ( 2 - 4 ). Reports have shown that breast cancer patients have a high prevalence of vitamin D deficiency ( 5 - 7 ). Vitamin D is influenced by many factors such as old age, high body mass index (BMI), high latitude, cold seasons, low sunlight exposure, and dark skin pigmentation which are associated with hypovitaminosis D ( 8 ).…”

Section: Contextmentioning

confidence: 99%

The Correlation of Plasma 25-Hydroxyvitamin D Deficiency With Risk of Breast Neoplasms: A Systematic Review

Shekarriz‐Foumani

Khodaie

2016

Iran J Cancer Prev

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ContextBreast cancer has been considered as one of the most common types of cancer among the women worldwide, and patients with breast neoplasms have been reported with high prevalence of low serum 25-hydroxyvitamin D levels.ObjectivesOur aim was to evaluate the correlation of plasma 25-hydroxyvitamin D deficiency with breast neoplasms risk among women.Data SourcesPubMed database was searched with MeSH (medical subject headings) keywords "vitamin D AND breast neoplasms" which was restricted by original articles written only in English and published from January 1, 2014.Study SelectionTo find the articles that met eligibility criteria, titles and abstracts were examined.Data ExtractionThis systematic review was conducted according to PRISMA (preferred reporting items for systematic reviews and meta-analyses) statement. Critical appraising of evidence was performed, using the study quality assessment tools of national institutes of health, national heart, lung and blood institute (NHLBI).ResultsOverall, 76 potential articles were identified and after screening, 13 articles met eligible criteria for inclusion. Definition of low vitamin D levels varied greatly among studies, making comparisons difficult, but most of them have defined deficiency as 25(OH)D < 20 ng/mL. Evidence was mainly of fair quality.ConclusionsThis study has provided evidence that vitamin D deficiency has been very prevalent in patients with breast neoplasms, more than comparable matched control population, and risk of breast cancer has increased with low vitamin D levels, suggesting the need for high quality studies that assessed the health consequences attributable to vitamin D deficiency employing standard definitions.

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“…Strong evidence indicate possible protective roles of vitamin D against cancers, bone fractures, cardiovascular diseases (CVD), autoimmune diseases, type-2 diabetes, influenza and depression (5). Epidemiologic studies support possible protective roles of vitamin D in cancers, including colorectal (6,7) breast (8,9), prostate (10, 11), ovarian (12) and kidney cancers (13). However, the association of vitamin D with risk of skin cancer has to be clarified (14).…”

Section: Introductionmentioning

confidence: 99%

Are there Relationships between the VDR-FokI Polymorphism and Vitamin D and the Insulin Resistance in Non-melanoma Skin Cancer (NMSC) Patients? A Protocol for Case-control Studies

2020

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Background and Objectives: Evidence indicate relationships between the sunlight exposure, vitamin D status and non-melanoma skin cancer (NMSC) risk. Vitamin D receptor (VDR) polymorphisms have been linked to metabolic changes in insulin resistance and various cancers. The purpose of this study is to investigate relationships between the sunlight exposure and the NMSC risk. Furthermore, relationships between the VDR FokI polymorphism and vitamin D status and the insulin resistance in NMSC patients will be assessed. Materials and Methods: A hospital-based case-control study is designed. Participants are randomly categorized into case and control groups. Eligible patients are adults who meet the inclusion criteria with verified diagnosis of NMSC with signed informed consents. Totally, 73 NMSC diagnosed cases and 72 healthy controls are recruited and their sunlight exposure data and genetic information are collected via interviews and high-resolution melting (HRM), respectively. Conclusions: There are controversial reports on the relevance of sunlight exposure to non-melanoma skin cancer risk due to the dual effect of UVB radiation on promoting vitamin D 3 synthesis in the skin and increasing DNA damage leading to skin cancer. Results of this study provide data on how much sunlight exposure includes beneficial health effects with no skin cancer risks. Vitamin D status may affect risks of insulin resistance-linked diseases such as cancers. Findings will contribute to the current knowledge of the roles of vitamin D, insulin resistance and FokI polymorphism in skin cancer development.

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Vitamin D and Its Relationship with Breast Cancer: An Evidence Based Practice Paper

Cited by 12 publications

References 12 publications

Nocturnal light pollution and underexposure to daytime sunlight: Complementary mechanisms of circadian disruption and related diseases

Nocturnal light pollution and underexposure to daytime sunlight: Complementary mechanisms of circadian disruption and related diseases

The Correlation of Plasma 25-Hydroxyvitamin D Deficiency With Risk of Breast Neoplasms: A Systematic Review

Are there Relationships between the VDR-FokI Polymorphism and Vitamin D and the Insulin Resistance in Non-melanoma Skin Cancer (NMSC) Patients? A Protocol for Case-control Studies

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