Vitamin D and living in northern latitudes—an endemic risk area for vitamin D deficiency

Huotari, Anne; Herzig, Karl‐Heinz

doi:10.3402/ijch.v67i2-3.18258

Cited by 118 publications

(88 citation statements)

References 94 publications

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“…The seasonal variation of vitamin D serum levels is a common phenomenon in the northern hemisphere at latitudes greater than around 40°N, where sunlight is not intense enough to generate vitamin D synthesis in the skin from October to March [18,19]. We may consider that the seasonal deficit in sunlight during the winter months may especially affect elderly patients with high cardiovascular risk, having more deleterious effect on them [20].…”

Section: Discussionmentioning

confidence: 99%

“…It has been generally accepted that blood 25(OH)D levels below 10 ng/mL (or 25 nmol/L) are qualified as 'deficient', but there is no currently accepted definition for 'optimal' 25(OH)D levels [18]. In the Central European population the correct target for supplementation is 30-50 ng/mL (75-125 nmol/L) [11]; nevertheless, the 25(OH)D concentration should exceed 30 ng/mL (75 nmol/L) to maximise the effect of vitamin D on calcium metabolism [18].…”

Section: Discussionmentioning

confidence: 99%

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Seasonal effect of vitamin D deficiency in patients with acute myocardial infarction

et al. 2016

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A b s t r a c tBackground: Vitamin D is a major regulator of mineral bone metabolism. The lower vitamin D levels in patients with acute myocardial infarction (AMI) and the seasonal variation of vitamin D levels are proposed. Aim:The evaluation of the seasonal relationship of 25(OH)D levels in patients with AMI and analysis of confounding factors (gender or diabetes mellitus) affecting the levels of vitamin D in AMI patients.Methods: Fifty-nine consecutive patients with mean age 58 ± 9.4 years were admitted to the Department of Invasive Cardiology. Subjects had diagnosed uncomplicated myocardial infarction. Blood samples for analysis were collected on patient admission to the cardiac unit after heparin treatment. Samples for routine laboratory tests were immediately processed. For 25(OH)D, the 25-hydroxycholecalciferol test, which measures total vitamin D levels in serum (DRG Instruments GmbH, Marburg, Germany), was applied.Results: Median serum 25(OH)D concentration in AMI patients was below the recommended optimal values 7.1 (2.3-13.3) ng/mL. Fifty-three (89.8%) patients had vitamin D deficiency (VDD) below 20 ng/mL, six (10.2%) patients had suboptimal 25(OH)D levels (between 20 ng/mL and 30 ng/mL), and no one had the recommended reference range. The seasonal effect of 25(OH)D variations among AMI patients was observed with the lowest levels in the beginning of the year (January-March) and the highest levels at the end of the year (September-December) (p = 0.007). Patients with normoglycaemia had significantly higher (9.2 [2.3-16.8] ng/mL) vitamin D levels compared to patients with impaired glucose tolerance (2.3 [2.3-3.9] ng/mL) or diabetes mellitus (8.5 [2.5-13.3] ng/mL) (p = 0.01). Conclusions:A high prevalence of VDD in AMI patients has been confirmed. Supplementation of vitamin D in AMI patients with hyperglycaemia can bring greater benefits.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Seasonal effect of vitamin D deficiency in patients with acute myocardial infarction

et al. 2016

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“…For example, a number of models of intracellular calcium metabolism were discovered. It would be worthwhile developing one of these models further to include Vitamin D metabolism, especially as Vitamin D is essential for calcium absorption [92], with its physiological optimum defined by the amount required to maintain calcium levels and prevent secondary hyperparathyroidism [93]. Therefore, a computer model could help to investigate the long-term impact of vitamin D deficiency on calcium metabolism.…”

Section: Discussionmentioning

confidence: 99%

Nutrition Research and the Impact of Computational Systems Biology

Auley¹

2013

J Comput Sci Syst Biol

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The value of computational modelling in improving our understanding of complex nutrient-based pathways is becoming increasingly recognised. This is due to the integral role that computer modelling is playing within the multidisciplinary field of systems biology, where in silico quantitative simulations are being used to compliment more traditional wet-laboratory investigations. A large number of computational models are accessible via the Biomodels database, an archive of openly available peer reviewed models of biological systems. Moreover, there has been an explosion in the availability of free modelling software tools that can be used to assemble and simulate the dynamic behaviour of nutrient mediated systems. Computational modelling will continue to play an increasingly significant role in nutrition research. Thus, it is important that freely accessible models and resources relevant to nutrition research are highlighted. In response to these needs, we firstly examined the Biomodels database, to identify and categorise nutrition themed models. The outcome of the analysis revealed 163 nutrition themed models. These models are mainly cellular in nature, with intracellular representations of calcium oscillations the most common. Secondly, a generic nutrition centred modelling framework was used, to explore recent advances, data repositories and software relevant to model building. We conclude this paper by using our review findings to discuss areas of nutrition that could further exploit the potential of computational modelling in the future. As a result of the progress in nutrient centred systems modelling it is important that freely available models, approaches, software and data resources relevant to nutrient focused modelling are highlighted. As a result of these needs, the aim of this paper is to discuss the progress in systems modelling and its relevance to nutrition research. Firstly, we will briefly introduce the main modelling approaches. We then highlight openly accessible nutrient themed models archived within the Biomodels database http://www.ebi.ac.uk/biomodels-main/ a repository for published peer reviewed models [22]. These models have been encased within the System Biology Markup Language (SBML) http://sbml.org/Main_Page a format used for model exchange [23]. We recognise that several formats exist for exchanging computational models, including the Cell Mark-up language (Cell-ML) [24] and the recently developed simulation experiment description markup language (SED-ML) [25], which also supports SBML. However, the rationale for focusing on SBML is because it is currently the leading exchange format in Systems Biology. This is emphasized by the results of a search of PubMed and Biomodels for models or tools published in each year since SBML was launched in 2003. The search terms SBML/ systems biology markup language were used to search for publications archived in PubMed. Biomodels was then used to crosscheck for models not revealed by the PubMed search. Figure 1 provides a summary of this ...

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“…Low BMD is prevalent in newly diagnosed MS patients with no or minor physical disability [12]. Patients from Finland already have low vitamin D levels owing to a deficit of solar radiation and a low vitamin D intake [22,23]. Mean vitamin D levels in the general Danish population have been reported to be sufficient [24].The low level of vitamin D in Finnish population could increase the risk of osteoporosis and may partly explain the higher number of vertebrae fractures in our MS cohort compared to Danish database.…”

Section: Discussionmentioning

confidence: 99%

High Frequency of Fractures in an Early Stage of MS

Krökki¹,

Bloigu²,

Remes

2013

J Mult Scler

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Objective: Low-energy (fragility) fractures of the distal forearm, femur, and vertebrae are usually associated with osteoporosis. There is an increased risk of fractures and low bone mineral density in patients with MS, even during the early stages of the disease. We evaluated the prevalence and features of low-energy fractures in a populationbased MS cohort residing in a region of Finland near the Arctic. Methods:The prevalence of fractures was determined in 491 patients who had been newly diagnosed with clinically definite MS. The fracture type, as well as the association between the duration of MS and the expanded disability status scale (EDSS) score, with a fracture event was determined. Results:The prevalence of fragility fractures was 7.1%. The most frequent fracture types were vertebral (19.2%), distal forearm (19.2%), and ankle (25%), and the majority were low-energy fractures. The majority of fractures occurred within five years of MS diagnosis verification in non-disabled to moderately disabled patients (EDSS score 0-4). The mean MS patient age at which low-energy fracture events occurred was 42.5 years (95% CI, 38.3-46.6 years). Osteoporosis had only been clinically investigated in 26% of patients with fragility fractures, 89% of whom returned a positive finding. Conclusions:The prevalence of low-energy vertebrae fractures was notably high in the present cohort; however, the presence of osteoporosis was poorly evaluated in clinical practice for this cohort.

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Vitamin D and living in northern latitudes—an endemic risk area for vitamin D deficiency

Cited by 118 publications

References 94 publications

Seasonal effect of vitamin D deficiency in patients with acute myocardial infarction

Seasonal effect of vitamin D deficiency in patients with acute myocardial infarction

Nutrition Research and the Impact of Computational Systems Biology

High Frequency of Fractures in an Early Stage of MS

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