Vitamin D and Metabolic Diseases: Growing Roles of Vitamin D

Park, Jung Eun; Pichiah, P.B. Tirupathi; Cha, Youn‐Soo

doi:10.7570/jomes.2018.27.4.223

Cited by 79 publications

(62 citation statements)

References 88 publications

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“…Vitamin D is essential for a series of physiological processes, such as the absorption of calcium and phosphate by the intestine, the regulation of bone remodelling and skeletal mineralisation as well as the negative feedback action on PTH secretion [ 3 , 98 , 134 , 135 , 136 , 137 , 138 ]. Therefore, in the case of a low vitamin D status, the capability of the small intestine to absorb dietary calcium [ 4 , 139 , 140 ] can be sensibly reduced with clinical implications not only for bone health but also for several metabolic functions [ 139 , 141 ].…”

Section: Vitamin D: State Of the Artmentioning

confidence: 99%

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Understanding the Biological Activities of Vitamin D in Type 1 Neurofibromatosis: New Insights into Disease Pathogenesis and Therapeutic Design

Riccardi

Perrone

Napolitano

et al. 2020

Cancers

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Vitamin D is a fat-soluble steroid hormone playing a pivotal role in calcium and phosphate homeostasis as well as in bone health. Vitamin D levels are not exclusively dependent on food intake. Indeed, the endogenous production—occurring in the skin and dependent on sun exposure—contributes to the majority amount of vitamin D present in the body. Since vitamin D receptors (VDRs) are ubiquitous and drive the expression of hundreds of genes, the interest in vitamin D has tremendously grown and its role in different diseases has been extensively studied. Several investigations indicated that vitamin D action extends far beyond bone health and calcium metabolism, showing broad effects on a variety of critical illnesses, including cancer, infections, cardiovascular and autoimmune diseases. Epidemiological studies indicated that low circulating vitamin D levels inversely correlate with cutaneous manifestations and bone abnormalities, clinical hallmarks of neurofibromatosis type 1 (NF1). NF1 is an autosomal dominant tumour predisposition syndrome causing significant pain and morbidity, for which limited treatment options are available. In this context, vitamin D or its analogues have been used to treat both skin and bone lesions in NF1 patients, alone or combined with other therapeutic agents. Here we provide an overview of vitamin D, its characteristic nutritional properties relevant for health benefits and its role in NF1 disorder. We focus on preclinical and clinical studies that demonstrated the clinical correlation between vitamin D status and NF1 disease, thus providing important insights into disease pathogenesis and new opportunities for targeted therapy.

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Section: Vitamin D: State Of the Artmentioning

confidence: 99%

“…Interestingly, in diabetes, vitamin D supplementation promotes insulin secretion [ 80 , 141 , 158 , 159 , 160 , 161 , 162 , 163 , 164 ]. Indeed, 25(OH)D levels are typically lower in obese individuals who are more likely to develop diabetes mellitus and metabolic syndromes [ 165 , 166 , 167 , 168 ].…”

Section: Vitamin D: State Of the Artmentioning

confidence: 99%

Understanding the Biological Activities of Vitamin D in Type 1 Neurofibromatosis: New Insights into Disease Pathogenesis and Therapeutic Design

Riccardi

Perrone

Napolitano

et al. 2020

Cancers

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“…Exclusion criteria involved (1) non-randomized trials, (2) comparing vitamin D 3 buccal spray against placebo, or (3) studies performed on animals.…”

Section: Search Eligibility Criteriamentioning

confidence: 99%

“…Vitamin D 3 is an essential fat-soluble nutrient involved in a plethora of metabolic pathways [1][2][3][4][5]. When consumed within the dietary reference level limits, vitamin D exerts multiple health…”

Section: Introductionmentioning

confidence: 99%

Efficacy of Vitamin D3 Buccal Spray Supplementation Compared to Other Delivery Methods: A Systematic Review of Superiority Randomized Controlled Trials

et al. 2020

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(1) Background: Vitamin D deficiency is an important public health concern and supplementation is common for this deficiency. Many different modes of delivering supplementation have been proposed in order to enhance absorption and utilization. The present review compared the efficacy of vitamin D3 buccal spray against other forms of supplementation delivery. (2) Methods: The protocol was registered at PROSPERO (CRD42019136146). Medline/PubMed, CENTRAL and clinicaltrials.gov were searched from their inception until September 2019, for randomized controlled trials (RCTs) that compare vitamin D3 delivery via sublingual spray against other delivery methods. Eligible RCTs involved humans, of any age and health status, published in any language that evaluated changes in plasma 25(OH)D concentrations. Three reviewers independently extracted data, assessed risk of bias (RoB) and the quality of the trials. (3) Results: Out of 9759 RCTs, four matched the predefined criteria. Intervention duration ranged from 30 days to 3 months whereas vitamin D3 dosage ranged between 800 and 3000 IU/day. One RCT advocated for the superiority of buccal spray in increasing plasma 25(OH)D concentrations, although several limitations were recorded in that trial. The rest failed to report differences in post-intervention 25(OH)D concentrations between delivery methods. Considerable clinical heterogeneity was observed due to study design, intervention duration and dosage, assays and labs used to perform the assays, population age and health status, not allowing for synthesis of the results. (4) Conclusions: Based on the available evidence, delivery of vitamin D3 via buccal spray does not appear superior to the other modes of delivery. Future RCTs avoiding the existing methodological shortcomings are warranted.

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“…In the formation of obesity; genetics, endocrine disorders, eating habits, unhealthy eating, lack of physical activity, gender, age, smoking, alcohol, drug use, stress, environmental, cultural and psychological factors play a key role (Kahraman, 2018;Park et al, 2018). Obesity is a disease that causes physiological, organic and systemic problems as well as psychological problems.…”

Section: Introductionmentioning

confidence: 99%

Examination of Obesity Awareness Levels of Physical Education Teacher and Coaching Education

Genç

Tunç²

2019

JETS

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Scale was developed by Allen (2011) and adapted to Turkish by Kafkas and Özen (2014) and personal information form including age, gender and department variable were applied to the participants. The data obtained in the study were analyzed with SPSS 20.0 statistical package program and the level of significance was taken as (p <0.05). The overall internal consistency of the scale was found to be 0.87. In the study, t-test was used for pairwise comparisons of parametric tests. In our study, no significant difference was found between gender variable and obesity awareness (p>.05). There was no significant difference between obesity awareness and department variable (p>.05). When the obesity awareness scores were examined, the average score of the students of the coaching department was average 62.23 meanwhile the teaching department students average score 62,91. It was found that both physical education teachers and coaching department students had high obesity awareness, but there was no significant difference between the groups in terms of department and gender variables and obesity awareness.

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Vitamin D and Metabolic Diseases: Growing Roles of Vitamin D

Cited by 79 publications

References 88 publications

Understanding the Biological Activities of Vitamin D in Type 1 Neurofibromatosis: New Insights into Disease Pathogenesis and Therapeutic Design

Understanding the Biological Activities of Vitamin D in Type 1 Neurofibromatosis: New Insights into Disease Pathogenesis and Therapeutic Design

Efficacy of Vitamin D3 Buccal Spray Supplementation Compared to Other Delivery Methods: A Systematic Review of Superiority Randomized Controlled Trials

Examination of Obesity Awareness Levels of Physical Education Teacher and Coaching Education

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