Vitamin D and Microbiota: Is There a Link with Allergies?

Murdaca, Giuseppe; Gerosa, Alessandra; Paladin, Francesca; Petrocchi, L; Banchero, Sara; Gangemi, Sebastiano

doi:10.3390/ijms22084288

Cited by 70 publications

(35 citation statements)

References 125 publications

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“…Since vitamin D was shown to decrease VEGF in clinical trials, it will be important to determine how well 17,20S(OH) 2 pD decreases VEGF in SSc patients in future studies [50]. Moreover, since the immune system and microbiome are interconnected and vitamin D was shown to be critical for maintaining a healthy microbiome, it will be of interest to study how 17,20S(OH) 2 pD affects the microbiome in scleroderma and other autoimmune patients [51].…”

Section: Discussionmentioning

confidence: 99%

17,20S(OH)2pD Can Prevent the Development of Skin Fibrosis in the Bleomycin-Induced Scleroderma Mouse Model

Lobbins

Scott

Slominski

et al. 2021

IJMS

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Systemic sclerosis (SSc; scleroderma) is a chronic fibrotic disease involving TGF-β1. Low serum vitamin D (vit D) correlates with the degree of fibrosis and expression of TGF-β1. This study was designed to determine whether the noncalcemic vit D analog, 17,20S(OH)2pD, suppresses fibrosis and mediators of the TGF-β1 pathway in the bleomycin (BLM) model of fibrosis. Fibrosis was induced into the skin of female C57BL/6 mice by repeated injections of BLM (50 μg/100 μL) subcutaneously. Mice received daily oral gavage with either vehicle (propylene glycol) or 17,20S(OH)2pD using 5, 15, or 30 μg/kg for 21 days. The injected skin was biopsied; analyzed histologically; examined for total collagen by Sircol; and examined for mRNA expression of MMP-13, BMP-7, MCP-1, Gli1, and Gli2 by TR-PCR. Spleen was analyzed for lymphocytes using flow cytometry. Serum was analyzed for cytokines using a multiplexed ELISA. Results showed that all three doses of 17,20S(OH)2pD suppressed net total collagen production, dermal thickness, and total collagen content in the BLM fibrosis model. 17,20S(OH)2pD also increased MMP-13 expression, decreased MCP-1 and Gli-2 expression in vivo, and suppressed serum levels of IL-13, TNF-α, IL-6, IL-10, IL-17, and IL-12p70. In summary, 17,20S(OH)2pD modulates the mediators of fibrosis in vivo and suppresses total collagen production and dermal thickness. This antifibrotic property of 17,20S(OH)2pD offers new therapeutic approaches for fibrotic disorders.

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Section: Discussionmentioning

confidence: 99%

17,20S(OH)2pD Can Prevent the Development of Skin Fibrosis in the Bleomycin-Induced Scleroderma Mouse Model

Lobbins

Scott

Slominski

et al. 2021

IJMS

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“…The physiological function of VD is to control calcium homeostasis for maintaining bone mineralization. Moreover, VD can modulate innate and adaptive immunity, induce cell differentiation, apoptosis, and autophagy; inhibit cell proliferation, angiogenesis and metastasis; and regulate other cellular signaling processes ( El-Sharkawy and Malki, 2020 ; Adelani et al, 2021 ; Murdaca et al, 2021 ; Pi et al, 2021 ; Poursoltani et al, 2021 ; Zhao et al, 2021 ; Bhutia, 2022 ; Zhou et al, 2022 ). Since VD levels obtained from diet are often insufficient and VD deficiency is associated with a variety of diseases, a daily supplement of at least 25 μg (1,000 IU) of VD is recommended to prevent VD deficiency ( Holick et al, 2011 ).…”

Section: Vitamin D—metabolism Analogues and Functionsmentioning

confidence: 99%

Vitamin D: A Potential Star for Treating Chronic Pancreatitis

Zheng

Gao

2022

Front. Pharmacol.

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Chronic pancreatitis (CP) is a chronic inflammatory and fibrotic disease of the pancreas. The incidence of CP is increasing worldwide but the effective therapies are lacking. Hence, it is necessary to identify economical and effective agents for the treatment of CP patients. Vitamin D (VD) and its analogues have been confirmed as pleiotropic regulators of cell proliferation, apoptosis, differentiation and autophagy. Clinical studies show that VD deficiency is prevalent in CP patients. However, the correlation between VD level and the risk of CP remains controversial. VD and its analogues have been demonstrated to inhibit pancreatic fibrosis by suppressing the activation of pancreatic stellate cells and the production of extracellular matrix. Limited clinical trials have shown that the supplement of VD can improve VD deficiency in patients with CP, suggesting a potential therapeutic value of VD in CP. However, the mechanisms by which VD and its analogues inhibit pancreatic fibrosis have not been fully elucidated. We are reviewing the current literature concerning the risk factors for developing CP, prevalence of VD deficiency in CP, mechanisms of VD action in PSC-mediated fibrogenesis during the development of CP and potential therapeutic applications of VD and its analogues in the treatment of CP.

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“…Several studies performed on VD3 have highlighted the fundamental role that it plays not only as a proskeletal agent, but also as an immunomodulator [ 20 ]. In recent years, moreover, there has been a focus on the role that vitamin D plays in the pathophysiology of chronic inflammatory respiratory disorders such as allergic rhinitis, chronic rhinosinusitis, and asthma [ 21 , 22 ]. In particular, allergic rhinitis has shown an imbalance in the Th1/Th2 ratio favoring Th2 [ 23 , 24 ].…”

Section: Vitamin D3mentioning

confidence: 99%

Role of Vitamin D in the Clinical Course of Nasal Polyposis

2021

Self Cite

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Vitamin D is a lipo-soluble hormone well known for its effects on calcium homeostasis and bone metabolism. Recently, there has been growing interest in the extraskeletal effects of vitamin D. In particular, recent studies have highlighted how vitamin D plays a fundamental role in immunomodulation processes in the context of both innate and adaptive immunity, with consequent anti-inflammatory and anti-oxidant effect in different immune-mediated pathologies, such as systemic sclerosis, psoriasis, atopic dermatitis and rheumatoid arthritis; as well as in various pro-inflammatory processes affecting the airways, including chronic rhinosinusitis with (CRSwNP) or without (CRSsNP) nasal polyposis. We analyze the role of vitamin D in the genesis and progression of CRSwNP/sNP and its supplementation as a safe and valid therapeutic strategy capable of improving the clinical outcome of standard therapies.

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Vitamin D and Microbiota: Is There a Link with Allergies?

Cited by 70 publications

References 125 publications

17,20S(OH)2pD Can Prevent the Development of Skin Fibrosis in the Bleomycin-Induced Scleroderma Mouse Model

17,20S(OH)2pD Can Prevent the Development of Skin Fibrosis in the Bleomycin-Induced Scleroderma Mouse Model

Vitamin D: A Potential Star for Treating Chronic Pancreatitis

Role of Vitamin D in the Clinical Course of Nasal Polyposis

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