Vitamin D and microbiota: Two sides of the same coin in the immunomodulatory aspects

Malaguarnera, Lucia

doi:10.1016/j.intimp.2019.106112

Cited by 73 publications

(68 citation statements)

References 179 publications

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“…Besides insulin therapy and probiotic supplementation, other interventional measures like whole-body vibration, increased exercise, and nutritional changes, which aimed to decrease insulin resistance (IR), improve BG control, and restore intestinal eubiosis, were shown to significantly downregulate LGI by decreasing IL-6, TNF-α, and IL-1-β levels (36)(37)(38)(39)(40). Although there is no direct evidence certifying a protective effect of supplements like Vitamin C, Vitamin D, Zinc, probiotics, and synbiotics on COVID-19 outcomes, we are hypothesizing that preventive measures targeting LGI can lower the propensity to develop severe disease (41)(42)(43)(44). Unlike drug-based therapies, the side effects of supplements are extremely mild (diarrhea, bloating, headaches, antibiotic resistance); however, further studies are necessary to confirm safe usage.…”

Section: Therapeutic and Preventive Strategiesmentioning

confidence: 99%

Prevention of Severe Coronavirus Disease 2019 Outcomes by Reducing Low-Grade Inflammation in High-Risk Categories

Ciornei

2020

Front. Immunol.

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Section: Therapeutic and Preventive Strategiesmentioning

confidence: 99%

Prevention of Severe Coronavirus Disease 2019 Outcomes by Reducing Low-Grade Inflammation in High-Risk Categories

Ciornei

2020

Front. Immunol.

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“…Similarly, in RCT conducted among 109 patients of NAFLD diagnosed by USG and liver enzymes, supplementation with vitamin D3 (50,000 IU/day; for 12 weeks) affected increased serum vitamin D, and a decrease in HOMA-IR accompanied this rise in the ALT, AST, and serum CRP and increase in serum adiponectin [178]. Vitamin D also influencedthe GM composition [179]. Asystematic review of in vivo trials (n-24) suggested that low vitamin D levels may be associated with an increase in Bacteroidetes.…”

Section: Vitamin E and Vitamin D And Nafldmentioning

confidence: 95%

Nutritional Approach Targeting Gut Microbiota in NAFLD—To Date

Moszak

Szulińska

Walczak-Gałęzewska

et al. 2021

IJERPH

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Non-alcoholic fatty liver disease (NAFLD) is a significant clinical and epidemiological problem that affects around 25% of the adult global population. A large body of clinical evidence highlights that NAFLD is associated with increased liver-related morbidity and mortality and an increased risk of cardiovascular disease, extrahepatic cancers, type 2 diabetes, and chronic kidney disease. Recently, a series of studies revealed the pivotal role of gut microbiota (GM) dysbiosis in NAFLD’s pathogenesis. The GM plays an essential role in different metabolic pathways, including the fermentation of diet polysaccharides, energy harvest, choline regulation, and bile acid metabolism. One of the most critical factors in GM stabilization is the diet; therefore, nutritional therapyappearsto be a promising tool in NAFLD therapy. This paper aims to review the current knowledge regardingthe nutritional approach and its implications with GM and NAFLD treatment. We discuss the positive impact of probiotics, prebiotics, and symbiotics in a reverse dysbiosis state in NAFLD and show the potential beneficial effects of bioactive substances from the diet. The full description of the mechanism of action and comprehensive examination of the impact of nutritional interventions on GM modulation may, in the future, be a simple but essential tool supporting NAFLD therapy.

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“…Previous studies have demonstrated that vitamin D has an important immunomodulatory function. Several immune cells (such as T cells, B cells, neutrophils and APCs) express vitamin D receptor, allowing vitamin D to regulate the balance between pro-inflammatory and anti-inflammatory state (98). It can also mediate the antimicrobial peptide (CAMP) expression downstream of TLR activation, leading to phagosome formation and antimicrobial activity against pathogens (98).…”

Section: Vitamin Dmentioning

confidence: 99%

Exploring the Modulatory Effects of Gut Microbiota in Anti-Cancer Therapy

Deng

Chen

2021

Front. Oncol.

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In the recent decade, gut microbiota has received growing interest due to its role in human health and disease. On the one hand, by utilizing the signaling pathways of the host and interacting with the immune system, the gut microbiota is able to maintain the homeostasis in human body. This important role is mainly modulated by the composition of microbiota, as a normal microbiota composition is responsible for maintaining the homeostasis of human body, while an altered microbiota profile could contribute to several pathogenic conditions and may further lead to oncogenesis and tumor progression. Moreover, recent insights have especially focused on the important role of gut microbiota in current anticancer therapies, including chemotherapy, radiotherapy, immunotherapy and surgery. Research findings have indicated a bidirectional interplay between gut microbiota and these therapeutic methods, in which the implementation of different therapeutic methods could lead to different alterations in gut microbiota, and the presence of gut microbiota could in turn contribute to different therapeutic responses. As a result, manipulating the gut microbiota to reduce the therapy-induced toxicity may provide an adjuvant therapy to achieve a better therapeutic outcome. Given the complex role of gut microbiota in cancer treatment, this review summarizes the interactions between gut microbiota and anticancer therapies, and demonstrates the current strategies for reshaping gut microbiota community, aiming to provide possibilities for finding an alternative approach to lower the damage and improve the efficacy of cancer therapy.

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Vitamin D and microbiota: Two sides of the same coin in the immunomodulatory aspects

Cited by 73 publications

References 179 publications

Prevention of Severe Coronavirus Disease 2019 Outcomes by Reducing Low-Grade Inflammation in High-Risk Categories

Prevention of Severe Coronavirus Disease 2019 Outcomes by Reducing Low-Grade Inflammation in High-Risk Categories

Nutritional Approach Targeting Gut Microbiota in NAFLD—To Date

Exploring the Modulatory Effects of Gut Microbiota in Anti-Cancer Therapy

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