Vitamin D and obstructive sleep apnea: a systematic review and meta-analysis

Neighbors, Cindy Lee P; Noller, Michael; Song, Sungjin A.; Zaghi, Soroush; Neighbors, John; Feldman, David; Kushida, Clete A.; Camacho, Macario

doi:10.1016/j.sleep.2017.10.016

Cited by 48 publications

(34 citation statements)

References 40 publications

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“…Although there have been some clinical evidence linking sleep apnoea and vitamin D deficiency [38], few studies have investigated the association between sleep duration and circulating 25OHD levels or dietary vitamin D intake [53][54][55][56][57][58][59][60][61][62][63][64][65][66] (Table 4).…”

Section: Discussionmentioning

confidence: 99%

“…Vitamin D deficiency is associated with sleep apnoea [38] and sleep duration, however, there is conflicting data from intervention trials on the effect of vitamin D supplementation on sleep quality in men and women [39]. To our knowledge, no study has investigated the association between sleep duration and vitamin D status in adult Chinese populations.…”

Section: Introductionmentioning

confidence: 99%

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Sleep duration is associated with vitamin D deficiency in older women living in Macao, China: A pilot cross-sectional study

Liang²,

et al. 2020

PLoS ONE

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Chinese women are known to have both a high prevalence of metabolic syndrome (MetS) and vitamin D deficiency (serum 25-hydroxyvitamin D (25OHD) <50 nmol/l). Associations between sleep duration and circulating 25OHD have recently been reported but, to our knowledge, these associations have not been studied in older Chinese populations. We thus investigated whether sleep duration was associated with vitamin D status in a population from Macao, China, and whether sleep duration modified the association between MetS and vitamin D deficiency. In 207 older (>55 years) Macanese, anthropometry, blood samples and validated questionnaires, including sleep duration and cardiovascular risk factors, were simultaneously collected. On multivariable categorical analyses, those women, not men, who had short sleep duration (�6 hours (h)) were at a 2-fold risk for vitamin D deficiency (both <50 nmol/L and <37 nmol/L; OR = 1.94, 95%CI 1.29-2.92; OR = 2.05, 95%CI 1.06-3.98, respectively) and those who had longer sleep duration (>8 h) were 3-fold more likely to have vitamin D deficiency (OR = 3.07, 95%CI 1.47-6.39; OR = 2.75, 95%CI 1.08-7.00, respectively) compared to those with normal sleep duration (6-8 h). Both women and men with MetS were 2-fold more likely to have vitamin D deficiency (women: OR = 2.04, 95%CI 1.31-3.17; OR = 2.15, 95%CI 1.11-4.17, respectively; men: OR = 2.01, 95%CI 1.23-3.28; OR = 2.04, 95%CI 1.00-4.29, respectively). Moreover, women with both short sleep duration and MetS had an increased risk of vitamin D deficiency (OR = 3.26, 95%CI 1.10-9.64). These associations were not found in those with longer sleep. Men with longer sleep and MetS had a 5-fold risk of vitamin D deficiency (OR = 5.22; 95%CI 2.70-10.12). This association was non-significant for men with shorter sleep. We conclude that both short and long sleep duration were associated with vitamin D deficiency in older Chinese women. Further research is needed in larger cohorts or with intervention studies to further examine the associations between reduced sleep, metabolic syndrome and vitamin D deficiency.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Sleep duration is associated with vitamin D deficiency in older women living in Macao, China: A pilot cross-sectional study

Liang²,

et al. 2020

PLoS ONE

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“…However, a systematic review and meta-analysis found relative insufficiency in serum 25(OH)D levels among obstructive sleep apnea patients compared to control patients, which was incrementally exacerbated with increasing severity of sleep apnea. 38 McCarty et al 39 reported that sleepiness was inversely correlated with vitamin D concentration in a vitamin D-sufficient group. However, in vitamin D-deficient groups, sleepiness was directly correlated with vitamin D levels in black, but not white participants.…”

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confidence: 99%

<p>Associations of 25-Hydroxyvitamin D Levels and Arthritis with Sleep Duration: The Korean National Health and Nutrition Examination Survey 2008–2014</p>

Kim

Lee

Lim

et al. 2020

NSS

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Purpose: The mean sleep duration of Koreans is 7 hours 49 minutes, which is the lowest among Organization for Economic Cooperation and Development countries. Although vitamin D deficiency and arthritis are considered modifiable factors influencing restorative sleep, mean vitamin D levels are low (17.33 ng/mL) and arthritis is prevalent among Koreans. This study investigated whether vitamin D deficiency and arthritis increase the risk of short sleep duration. Patients and Methods: The current study used data from the Korean National Health and Nutrition Examination Survey (KNHANES) for 46,405 Korean adults. Vitamin D levels were measured using a radioimmunoassay kit. Sleep duration and arthritis history were assessed using a self-reported questionnaire. Sleep duration was categorized as optimal (7 to <9 hours/day), short (<7 hours/day), and long (≥9 hours/day). Vitamin D levels were grouped as vitamin D sufficiency (≥20 ng/mL), insufficiency (10-19.99 ng/mL), and deficiency (<10 ng/mL). Multiple imputation was used to compensate for missing data. Multinomial logistic regression was used to examine the associations of vitamin D and arthritis status with sleep duration. The regressions were adjusted for covariates, and each model was adjusted for vitamin D and arthritis. Results: Among these participants, 23,078 (49.73%) and 3518 (7.58%) had short and long sleep duration, respectively; 26,724 (57.59%) and 4349 (9.37%) exhibited vitamin D insufficiency and deficiency, respectively; and 4709 (10.15%) were arthritis patients. Compared with vitamin D sufficiency, vitamin D insufficiency and deficiency were associated with short sleep duration (vitamin D insufficiency group: OR = 1.07, 95% CI = 1.01-1.13; vitamin D deficiency group: OR = 1.13, 95% CI = 1.03-1.24). The presence of arthritis was associated with short sleep duration (OR = 1.14, 95% CI = 1.06-1.22) compared with its absence. The interaction between vitamin D deficiency and the presence of arthritis was significantly associated with short sleep duration. However, long sleep duration was not significantly associated with vitamin D levels or arthritis status. Conclusion: Low vitamin D levels and the presence of arthritis were associated with an increased risk of short sleep duration. Additionally, there was a positive interaction effect between vitamin D deficiency and arthritis on short sleep duration.

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“…Upala and Sanguankeo [28] published the first systematic review and meta-analysis revealing the presence of lower vitamin D levels in patients with OSA compared to controls. In a more recent systematic review and meta-analysis, Neighbors et al [29] reported that a relative insufficiency in serum vitamin D levels was present in OSA patients compared to controls, which was incrementally exacerbated with increasing severity of sleep apnea. On the other hand, the underlying mechanism of a vitamin D and OSA association is less clear than its presentation.…”

Section: Vitamin D and Otolaryngological Diseasesmentioning

confidence: 99%

“…[31] Since higher body mass index is a common morbidity in OSA, lower levels of vitamin D in OSA patients may be associated with obesity rather than OSA. [29] In conclusion, further randomized controlled studies are needed to evaluate the association between OSA, vitamin D and obesity for a better understanding of underlying mechanisms. Vitamin D related calcium channel proteins in the epithe-lium are known to be involved in calcium metabolism of the vestibular organ.…”

Section: Vitamin D and Otolaryngological Diseasesmentioning

confidence: 99%

The Role Of Vitamin D In Otolaryngological Diseases: Myth Or Truth

Bayram¹

2018

ENT Updates

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In the present review, we aimed to evaluate the role of vitamin D in otolaryngological diseases. Since the recognition of vitamin D as a steroid hormone, it has attracted clinicians as a research issue due to its unique and complicated functions in human body processes. Numerous studies have investigated the association between vitamin D and human diseases, including in the otolaryngological field. However, although vitamin D alterations may theoretically be involved in the pathogenesis of several otolaryngological diseases, a clear association has not been demonstrated due to inconsistent results from the studies to date. Further randomized controlled trials with large patient populations are required to determine the exact role of vitamin D in otolaryngological diseases.

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Vitamin D and obstructive sleep apnea: a systematic review and meta-analysis

Cited by 48 publications

References 40 publications

Sleep duration is associated with vitamin D deficiency in older women living in Macao, China: A pilot cross-sectional study

Sleep duration is associated with vitamin D deficiency in older women living in Macao, China: A pilot cross-sectional study

<p>Associations of 25-Hydroxyvitamin D Levels and Arthritis with Sleep Duration: The Korean National Health and Nutrition Examination Survey 2008–2014</p>

The Role Of Vitamin D In Otolaryngological Diseases: Myth Or Truth

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