Vitamin D and Pain: Vitamin D and Its Role in the Aetiology and Maintenance of Chronic Pain States and Associated Comorbidities

Abstract

The emergence of new data suggests that the benefits of Vitamin D extend beyond healthy bones. This paper looks at Vitamin D and its role in the aetiology and maintenance of chronic pain states and associated comorbidities. The interfaces between pain and Vitamin D and the mechanisms of action of Vitamin D on pain processes are explored. Finally the association between Vitamin D and pain comorbidities such as sleep and depression is investigated. The paper shows that Vitamin D exerts anatomic, hormonal, neurological, and immunological influences on pain manifestation, thereby playing a role in the aetiology and maintenance of chronic pain states and associated comorbidities. More research is necessary to determine whether Vitamin D is useful in the treatment of various pain conditions and whether or not the effect is limited to patients who are deficient in Vitamin D.

Vitamin D for Depression with a Seasonal Pattern: an Effective Treatment Strategy

“…60 Clinical research studies indicate that low level of vitamin D is associated with chronic pain and comorbid depression. 61,62 Therefore, early identification of vitamin D deficiency in chronic pain patients with depression not only can have a beneficial therapeutic effect but also prevent disease progression.…”

Relation of serum 25(OH) D with variables of thyroid and lipid profile in perimenopausal women

“…Sunlight is the best sources of vitamin D since by direct exposure to sun, 10,000 to 20,000 IU of vitamin D can be produced in 30 minutes of whole body. 3 Dietary intake are the other sources of vitamin D in the body so its production in the skin depends on the exposure to sunlight, cloth covering, latitude, consuming nutritional diet or using of sunscreen lotions. 4 Since vitamin D plays an important role in bone metabolism, the deficiency with vitamin D is quite common in older age population or post-menopausal women having osteoporosis.…”

Kronik Yaygın Muskuloskeletal Ağrısı Olan Hastalarda Vitamin D Düzeyinin Belirlenmesi: Pilot Çalışma

“…Bunu dışında özellikle nöromusküler fonksiyonun sağlanması, enflamasyonun azaltılması ve kronik birçok hastalığın (çeşitli kanserler, otoimmün hastalıklar, enfeksiyöz hastalıklar, kardiyovasküler hastalıklar, vb.) riskinin azaltması gibi etkileri de bulunmaktadır (1)(2)(3)(4)(5). Çalışmalar, D vitamininin ağrı tedavisinde, anatomik, nörolojik ve immünolojik etkilerinin olduğunu göstermiştir.…”

“…Çalışmalar, D vitamininin ağrı tedavisinde, anatomik, nörolojik ve immünolojik etkilerinin olduğunu göstermiştir. Dolayısıyla D vitamini, kronik ağrının etiyolojisinde ve kronik ağrı durumlarının ve bu durumların oluşturduğu komorbiditenin tedavisinde etkin rol oynayabilir (1)(2)(3)(4). Fibromiyalji başta olmak üzere yaygın kas iskelet sistemi ağrısını inceleyen çalışmalardaki sonuçlar net veriler ortaya koyamamaktadır.…”