Vitamin D and periodontal disease

Amano, Yusuke; Komiyama, Kanki; Makishima, Makoto

doi:10.2334/josnusd.51.11

Cited by 65 publications

(66 citation statements)

References 69 publications

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“…Based on this case definition, we found that those consuming ≥ 800 IU/day of total vitamin D had lower odds of having periodontal disease compared with those consuming less than 400 IU/day. The medical literature regards vitamin D deficiency as a risk factor for osteoporosis, which may also affect the jaws (van Schoor et al, 2008;Amano et al, 2009).…”

Section: Discussionmentioning

confidence: 99%

Vitamin D and Periodontal Health in Older Men

et al. 2013

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Vitamin D, an anti-inflammatory mediator, has potential benefits for physical and oral health. Although it is produced endogenously, some individuals have a greater need for dietary and supplemental sources. This repeated-measures crosssectional study assessed associations between total vitamin D intake and periodontal health in older men. Participants were 562 members of the Department of Veterans Affairs Dental Longitudinal Study, mean age 62.9 years, who were examined 1 to 4 times between 1986 and 1998. A calibrated examiner measured probing pocket depth (PPD) and attachment loss (AL) on each tooth. Alveolar bone loss (ABL) was determined from radiographs. Severe periodontal disease was defined as PPD ≥ 5 mm on ≥ 1 tooth and AL ≥ 6 mm at ≥ 2 sites (not on same tooth), and moderate-to-severe alveolar bone loss as ABL ≥ 40% at ≥ 3 sites. Generalized estimating equations were used to compute the odds ratios (OR) and 95% confidence intervals (95% CI) of having periodontal disease by level of vitamin D intake. Total vitamin D intake ≥ 800 IU was associated with lower odds of severe periodontal disease (OR = 0.67, 95% CI = 0.55-0.81) and moderate-to-severe ABL (OR = 0.54, 95% CI = 0.30-0.96) relative to intake < 400 IU/day. Vitamin D intake may protect against periodontal disease progression.KEY WORDS: periodontal disease, alveolar bone, probing depth, clinical attachment loss, vitamin D intake, aging.

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Section: Discussionmentioning

confidence: 99%

Vitamin D and Periodontal Health in Older Men

et al. 2013

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“…These factors include: bacterial flora, poor oral hygiene, age, sex, diabetes, HIV, pregnancy, menopause, smoking, low socioeconomic status, and local factors (cavities, dental morphology, etc.). Some other general factors are stress, immune deficiency, and nutritional factors, which appear to modulate the body's immune response and determine the level of susceptibility to the disease [5]. The list of these risk factors remains controversial [6].…”

Section: Epidemiological Data In Francementioning

confidence: 99%

Impact of chronic stress on periodontal health

Gunepin¹,

Derache

Trousselard³

et al. 2018

J Oral Med Oral Surg

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--Introduction: Periodontal diseases are caused by pathogenic microorganisms that induce increases in of local and systemic proinflammatory cytokines, resulting in periodontal damage. The onset and evolution of periodontal diseases are influenced by many local and systemic risk factors. Educational objective: In this article, we aim to review the results of the research on the impact of chronic stress on the occurrence, development, and response to periodontal disease treatments and on the pathophysiological mechanisms of periodontal disease. Conclusion: Chronic stress has a negative impact on the occurrence, development, and response to the treatment of periodontal disease via indirect actions on the periodontium. This can result from behavioral changes caused by stress (poor dental hygiene, smoking, etc.) and a direct neuroimmunoendocrinological action related to the consequences (particularly immunological) of the secretion of certain chemicals (e.g., cortisol) induced by the activation of the hypothalamus and the autonomic nervous system in response to stress. These factors necessitate multidisciplinary management (e.g., physician, oral surgeon, and psychologist) of patients to identify subjects with chronic stress and to employ countermeasures to decrease the impact of stress on the periodontium.

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“…VDR binds preferentially to a vitamin D response element (VDRE), consisting of a two hexanucleotide (AGGTCA or a related sequence) direct repeat motif separated by three nucleotides (direct repeat 3; DR3), as a heterodimer with isoforms of the retinoid X receptor (RXR), RXRa (NR2B1), RXRb (NR2B2), and RXRg (NR2B3), the receptors for 9-cis retinoic acid [10,20] (see Section II of this volume). DR3-type VDREs have been identified in the regulatory regions of many target genes, including 25-hydroxyvitamin D 24-hydroxylase (CYP24A1), calbindin D9k (CaBP-9k), transient receptor potential vanilloid type 6 (TRPV6), receptor activator of nuclear receptor kB ligand and cathelicidin antimicrobial peptide (CAMP) [2,21,22].…”

Section: The Vitamin D Receptor Is a Dual-functional Receptor For Vitmentioning

confidence: 99%