Vitamin D and prognosis in acute myocardial infarction

Ng, Leong L.; Sandhu, Jatinderpal K.; Squire, Iain B.; Davies, Joan E.; Jones, Donald J. L.

doi:10.1016/j.ijcard.2013.01.030

Cited by 80 publications

(68 citation statements)

References 24 publications

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“…It has recently been reported that lower vitamin D levels may be associated with poor collateral vasculature development in patients with stable coronary artery disease [3]. The other cross-sectional analyses showed the associations between lower vitamin D levels and the risk of cardiovascular diseases or poor prognosis for patients with major adverse events (MACE) [3][4][5][6]. Moreover, the association between vitamin D deficiency (VDD) and endothelial dysfunction is well established [7].…”

Section: Introductionmentioning

confidence: 99%

“…In contrast to 25-hydroxyvitamin D (25(OH)D 3 ), which is a prohormone and the major circulating metabolite of vitamin D, the levels of 1a,25(OH) 2 D 3 are about 1000-fold lower than those of 25(OH)D 3 . Although 1a,25(OH) 2 D 3 portrays the biological active form of vitamin D, it is widely accepted that 25(OH)D is the robust indicator of vitamin D status in individuals, especially in hypovitaminosis or VDD [6].…”

Section: Introductionmentioning

confidence: 99%

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Seasonal effect of vitamin D deficiency in patients with acute myocardial infarction

et al. 2016

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A b s t r a c tBackground: Vitamin D is a major regulator of mineral bone metabolism. The lower vitamin D levels in patients with acute myocardial infarction (AMI) and the seasonal variation of vitamin D levels are proposed. Aim:The evaluation of the seasonal relationship of 25(OH)D levels in patients with AMI and analysis of confounding factors (gender or diabetes mellitus) affecting the levels of vitamin D in AMI patients.Methods: Fifty-nine consecutive patients with mean age 58 ± 9.4 years were admitted to the Department of Invasive Cardiology. Subjects had diagnosed uncomplicated myocardial infarction. Blood samples for analysis were collected on patient admission to the cardiac unit after heparin treatment. Samples for routine laboratory tests were immediately processed. For 25(OH)D, the 25-hydroxycholecalciferol test, which measures total vitamin D levels in serum (DRG Instruments GmbH, Marburg, Germany), was applied.Results: Median serum 25(OH)D concentration in AMI patients was below the recommended optimal values 7.1 (2.3-13.3) ng/mL. Fifty-three (89.8%) patients had vitamin D deficiency (VDD) below 20 ng/mL, six (10.2%) patients had suboptimal 25(OH)D levels (between 20 ng/mL and 30 ng/mL), and no one had the recommended reference range. The seasonal effect of 25(OH)D variations among AMI patients was observed with the lowest levels in the beginning of the year (January-March) and the highest levels at the end of the year (September-December) (p = 0.007). Patients with normoglycaemia had significantly higher (9.2 [2.3-16.8] ng/mL) vitamin D levels compared to patients with impaired glucose tolerance (2.3 [2.3-3.9] ng/mL) or diabetes mellitus (8.5 [2.5-13.3] ng/mL) (p = 0.01). Conclusions:A high prevalence of VDD in AMI patients has been confirmed. Supplementation of vitamin D in AMI patients with hyperglycaemia can bring greater benefits.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Seasonal effect of vitamin D deficiency in patients with acute myocardial infarction

et al. 2016

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“…Thus far, the largest study evaluating vitamin D and prognosis in ACS patients was that by Ng et al 13 They found an association between the lowest vitamin D quartile (<7.3 ng/mL) and long-term major adverse cardiovascular outcomes in 1259 patients. Notably, the association was predominantly with nonfatal adverse outcomes, such as re-hospitalization for ADHF (Acute decompensated heart failure) or for another ACS, rather than mortality.…”

Section: Association Between Vitamin D and In-hospital Outcomesmentioning

confidence: 99%

“…10 Very few studies, however, have investigated the association between vitamin D levels and clinical outcomes in ACS patients thus far. [11][12][13] Therefore, convincing data demonstrating the possible impact of vitamin D insufficiency, or deficiency, on morbidity and mortality of ACS patients are still lacking. Notably, vitamin D has been demonstrated to suppress the reninangiotensin system and to affect endothelial function, inflammatory processes, platelet function, insulin resistance, and blood pressure.…”

Section: Introductionmentioning

confidence: 99%

To evaluate the role of plasma vitamin D level as a prognostic marker and its relation to in-hospital complications in patients with acute coronary syndrome

Kumar

2016

Int J Adv Med

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Background: Deficiency in 25-hydroxyvitamin D (25[OH] D), the main circulating form of vitamin D in blood, could be involved in the pathogenesis of acute coronary syndromes (ACS). To date, however, the possible prognostic relevance of 25 (OH) D deficiency in ACS patients remains poorly defined. The purpose of this study was to assess the association between 25 (OH) D levels, at hospital admission, with in-hospital complications in an unselected cohort of ACS patients. Methods: We measured 25 (OH) D in 200 ACS patients at hospital presentation. Vitamin D serum levels >30 ng/mL were considered as normal; levels between 29 and 21 ng/mL were classified as insufficiency, and levels < 20 ng/mL as deficiency. In-hospital complications were evaluated according to 25 (OH) D levels. Results: In the study population 85(42.5%) patients had normal 25 (OH) D levels, whereas 36 (18%) and 79 (39.5%) had vitamin D insufficiency and deficiency, respectively. The patients with vitamin D deficiency were associated with a higher risk for several in-hospital MACEs (major adverse clinical events) including mortality and it was statistically significant (P value < 0.05). The left ventricular function was more severely compromised in patients with vitamin D deficiency and it was statistically significant (P value < 0.05). Conclusions: In ACS patients, severe vitamin D deficiency is independently associated with poor in-hospital outcomes. Whether low vitamin D levels represent a risk marker or a risk factor in ACS remains to be elucidated.

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“…While it is not a predictor of all causes of mortality. Moreover, the 25(OH)D level >7.3 ng/ml reduces the risk of nonfatal MACE by 40% within patients with acute coronary syndrome [47].…”

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confidence: 99%

Is Vitamin D a New Therapeutic Option in Coronary Artery Disease? Overview Data

browski¹

2015

Cardiol Pharmacol

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Vitamin D and prognosis in acute myocardial infarction

Cited by 80 publications

References 24 publications

Seasonal effect of vitamin D deficiency in patients with acute myocardial infarction

Seasonal effect of vitamin D deficiency in patients with acute myocardial infarction

To evaluate the role of plasma vitamin D level as a prognostic marker and its relation to in-hospital complications in patients with acute coronary syndrome

Is Vitamin D a New Therapeutic Option in Coronary Artery Disease? Overview Data

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