Vitamin D and prostate cancer: The role of membrane initiated signaling pathways in prostate cancer progression

Karlsson, Sandra; Olausson, Josefin; Lundh, Dan; Sögård, Peter; Mandal, Abul; Holmström, Kjell‐Ove; Stahel, Anette; J, Bengtsson; Larsson, D. G. Joakim

doi:10.1016/j.jsbmb.2010.03.083

Cited by 20 publications

(17 citation statements)

References 34 publications

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“…As shown in Figure 1 The data from this study supports previous observations in prostate cancer cells where 1α,25(OH) 2 D 3 decrease cell proliferation and where at least a part of the decreased proliferation has been connected an increase in the phosphorylation of JNK/SAPK and c-jun Hagberg et al, 2008;Karlsson et al, 2010). Effects on MAPK signaling pathways by 1α,25(OH) 2 D 3 is not limited to prostate cancer cells.…”

Section: Effects Of 1α25(oh) 2 D 3 On Ap1-dependent Gene Expressionsupporting

confidence: 89%

“…An example of a similar observation is membrane initiated signaling in skeletal muscle, where six different signaling pathways have been described for 1α,25(OH) 2 D 3 (Vasquez et al, 1996;Capiati et al, 2000;Dirks-Naylor and Lennon-Edwards, 2011). The point that there are two different vitamin D receptors (VDR, PDIA3) associated with the cell membrane (Holmen et al, 2009;Karlsson et al, 2010) and that PDIA3 has been suggested to form a trimer with at least three high affinity binding sites (Karlsson et al, 2010) make us to postulate that depending on the docking site of 1α,25(OH) 2 D 3 to the receptor, the resulting change in three dimensional structure of the hormone-receptor complex, starts a subsequent signaling cascade. The response will thus be dependent on both time and space where both short-term and long-term effect will be important in regulating prostate cell biology.…”

Section: Effects Of 1α25(oh) 2 D 3 On Tnf-α Production In Lncap Cellmentioning

confidence: 89%

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Membrane Initiated Effects of 1α,25-Dihydroxyvitamin D3 in Prostate Cancer Cells: Effects on AP1 and CREB Mediated Transcription

Larsson¹,

Jonas²,

Bergsten³

et al. 2012

Current Frontiers and Perspectives in Cell Biology

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Section: Effects Of 1α25(oh) 2 D 3 On Ap1-dependent Gene Expressionsupporting

confidence: 89%

Section: Effects Of 1α25(oh) 2 D 3 On Tnf-α Production In Lncap Cellmentioning

confidence: 89%

Membrane Initiated Effects of 1α,25-Dihydroxyvitamin D3 in Prostate Cancer Cells: Effects on AP1 and CREB Mediated Transcription

Larsson¹,

Jonas²,

Bergsten³

et al. 2012

Current Frontiers and Perspectives in Cell Biology

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“…Vitamin D promotes the differentiation of prostate cancer cells highlighting the possibility that vitamin D deficiency over time may contribute to the progression from subclinical prostate cancer to clinical disease. [13] Prior research has shown that vitamin D deficiency is an indicator of aggressive prostate cancer and spread of the disease in men who underwent their first prostate biopsy because of an abnormal PSA test. [14] Furthermore, a dose-response relationship between tumor grade and vitamin D levels was observed.…”

Section: Discussionmentioning

confidence: 99%

Null Association between Vitamin D and PSA Levels among Black Men in a Vitamin D Supplementation Trial

Chandler

Giovannucci

Scott

et al. 2014

Cancer Epidemiology, Biomarkers &Amp; Prevention

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Background Black men exhibit a high prevalence of vitamin D deficiency as well as higher incidence of prostate cancer and higher mortality rates from prostate cancer than Whites. There are few data about the effect of vitamin D3 (cholecalciferol) supplementation on prostate specific antigen (PSA) in healthy Black men. Methods During 3 winters from 2007–2010, 105 Black men (median age, 48.9 years) of Boston, MA were randomized into a 4-arm, double-blind trial for 3 months of placebo, 1000, 2000, or 4000 IU of vitamin D3. At baseline and 3 months, free and total PSA were measured. Results With vitamin D supplementation, no significant differences in free and total PSA were observed; free PSA: −0.0004 ng/mL (p=0.94) and total PSA: −0.004 ng/mL (p=0.92) for each additional 1000 IU/d of vitamin D3. Conclusion Within an unselected population of healthy Black men without a cancer diagnosis, we found no effect of vitamin D supplementation on free or total PSA. Impact These findings support prior findings of no change in PSA with vitamin D supplementation and emphasize the need for new methods to assess the influence of vitamin D supplementation on prostate cancer prevention.

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“…To date, a lot of studies have investigated the function of the interaction of ERp57 with calcitriol404142434445. Moreover, in a review on vitamin D analogues as potential therapeutics in melanoma, the 1,25-dihydroxy-lumisterol, locked in the 6-cis configuration, was cited as a vitamin D analogue which activates the rapid-response pathways and competes with 1α,25-dihydroxyvitamin D 3 for MARRS receptor binding, but not for VDR binding43.…”

Section: Discussionmentioning

confidence: 99%

Analysis of the interaction of calcitriol with the disulfide isomerase ERp57

Gaucci

Raimondo

Grillo

et al. 2016

Sci Rep

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Calcitriol, the active form of vitamin D3, can regulate the gene expression through the binding to the nuclear receptor VDR, but it can also display nongenomic actions, acting through a membrane-associated receptor, which has been discovered as the disulfide isomerase ERp57. The aim of our research is to identify the binding sites for calcitriol in ERp57 and to analyze their interaction. We first studied the interaction through bioinformatics and fluorimetric analyses. Subsequently, we focused on two protein mutants containing the predicted interaction domains with calcitriol: abb’-ERp57, containing the first three domains, and a’-ERp57, the fourth domain only. To consolidate the achievements we used the calorimetric approach to the whole protein and its mutants. Our results allow us to hypothesize that the interaction with the a’ domain contributes to a greater extent than the other potential binding sites to the dissociation constant, calculated as a Kd of about 10−9 M.

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Vitamin D and prostate cancer: The role of membrane initiated signaling pathways in prostate cancer progression

Cited by 20 publications

References 34 publications

Membrane Initiated Effects of 1α,25-Dihydroxyvitamin D3 in Prostate Cancer Cells: Effects on AP1 and CREB Mediated Transcription

Membrane Initiated Effects of 1α,25-Dihydroxyvitamin D3 in Prostate Cancer Cells: Effects on AP1 and CREB Mediated Transcription

Null Association between Vitamin D and PSA Levels among Black Men in a Vitamin D Supplementation Trial

Analysis of the interaction of calcitriol with the disulfide isomerase ERp57

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