Vitamin D and skeletal muscle: A narrative review focusing on chronic kidney disease and dialysis

Vogt, Barbara; Caramori, Jacqueline Costa Teixeira

doi:10.1111/hdi.12916

Cited by 3 publications

(3 citation statements)

References 79 publications

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“…Vitamin D deficiency is associated with sarcopenia and reduced physical activity in different populations, including the elderly and dialysis patients [402,403]. However, human studies on the effects of vitamin D supplementation on skeletal muscle are not consistent in their findings, and most likely outcomes depend on the underlying disease and differences in physical activity levels [402,404]. Vitamin D supplementation increases skeletal muscle mass and function and reduces the number of falls in older individuals [405,406].…”

Section: Vitamin D and Sarcopeniamentioning

confidence: 99%

“…Furthermore, clinical studies suggest a survival benefit of 1,25D therapy in CKD [411,412]. However, other clinical trials did not show improvement of muscle strength or function after supplementation with 1,25D [402]. In nephrectomized rats that receive a high-phosphate diet, the administration of 1,25D causes an increase in myofiber size, indicating that vitamin D might protect from CKD-associated skeletal muscle atrophy [254].…”

Section: Vitamin D and Sarcopeniamentioning

confidence: 99%

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Skeletal Muscle Injury in Chronic Kidney Disease—From Histologic Changes to Molecular Mechanisms and to Novel Therapies

Heitman,

Alexander,

Faul

2024

IJMS

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Chronic kidney disease (CKD) is associated with significant reductions in lean body mass and in the mass of various tissues, including skeletal muscle, which causes fatigue and contributes to high mortality rates. In CKD, the cellular protein turnover is imbalanced, with protein degradation outweighing protein synthesis, leading to a loss of protein and cell mass, which impairs tissue function. As CKD itself, skeletal muscle wasting, or sarcopenia, can have various origins and causes, and both CKD and sarcopenia share common risk factors, such as diabetes, obesity, and age. While these pathologies together with reduced physical performance and malnutrition contribute to muscle loss, they cannot explain all features of CKD-associated sarcopenia. Metabolic acidosis, systemic inflammation, insulin resistance and the accumulation of uremic toxins have been identified as additional factors that occur in CKD and that can contribute to sarcopenia. Here, we discuss the elevation of systemic phosphate levels, also called hyperphosphatemia, and the imbalance in the endocrine regulators of phosphate metabolism as another CKD-associated pathology that can directly and indirectly harm skeletal muscle tissue. To identify causes, affected cell types, and the mechanisms of sarcopenia and thereby novel targets for therapeutic interventions, it is important to first characterize the precise pathologic changes on molecular, cellular, and histologic levels, and to do so in CKD patients as well as in animal models of CKD, which we describe here in detail. We also discuss the currently known pathomechanisms and therapeutic approaches of CKD-associated sarcopenia, as well as the effects of hyperphosphatemia and the novel drug targets it could provide to protect skeletal muscle in CKD.

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Section: Vitamin D and Sarcopeniamentioning

confidence: 99%

Section: Vitamin D and Sarcopeniamentioning

confidence: 99%

Skeletal Muscle Injury in Chronic Kidney Disease—From Histologic Changes to Molecular Mechanisms and to Novel Therapies

Heitman,

Alexander,

Faul

2024

IJMS

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“…Inadequate vitamin D status is common among patients undergoing dialysis [10]. However, the associations of vitamin D status with gait speed and handgrip strength have not been well-established in this population [11,12]. The relationship between vitamin D status and gait speed was negative according to Kang et al [13].…”

Section: Introductionmentioning

confidence: 99%

Association of serum 25-hydroxy vitamin D with gait speed and handgrip strength in patients on hemodialysis

Chen

et al. 2022

BMC Nephrol

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Background Muscle dysfunction is prevalent in dialysis patients. Gait speed and handgrip strength are simple and reliable methods of assessing muscle function. Numerous observational studies have linked 25-hydroxy vitamin D[25(OH)D] status with gait speed and handgrip strength in populations without kidney diseases. This study aimed to evaluate the potential associations of 25(OH)D status with gait speed and handgrip strength in patients on hemodialysis. Methods In this observational cross-sectional study, demographic data, biological data, and dialysis parameters were collected. Gait speed and handgrip strength were measured. Multiple linear regression and logistic regression analysis were used to investigate the relationship of 25(OH)D status with gait speed and handgrip strength after adjusting for potential confounders. Results Overall, a total of 118 participants undergoing hemodialysis were included. Seventy-one (60.2%) participants were male. The median 25(OH)D status in participants was 11.58 (interquartile range: 8.51 to 15.41) ng/ml. When controlling for age, gender, dialysis vintage, and other confounders with a p-value < 0.15 in univariate analyses, 25(OH)D was significantly positively associated with gait speed (β = 0.16, 95% CI 0.05 to 0.28, p = 0.006) and handgrip strength (β = 3.83, 95% CI 1.09 to 6.56, p = 0.007). Conclusion Our study showed that 25(OH)D status seemed to be associated with gait speed and handgrip strength in patients on hemodialysis. However, these results were not robust. The relationships between 25(OH)D status and gait speed and handgrip should be further explored.

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Frailty in patients on dialysis

Chan,

Kalantar-Zadeh,

et al. 2024

Kidney International

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Vitamin D and skeletal muscle: A narrative review focusing on chronic kidney disease and dialysis

Cited by 3 publications

References 79 publications

Skeletal Muscle Injury in Chronic Kidney Disease—From Histologic Changes to Molecular Mechanisms and to Novel Therapies

Skeletal Muscle Injury in Chronic Kidney Disease—From Histologic Changes to Molecular Mechanisms and to Novel Therapies

Association of serum 25-hydroxy vitamin D with gait speed and handgrip strength in patients on hemodialysis

Frailty in patients on dialysis

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