Vitamin D and the nervous system

Bivona, Giulia; Gambino, Caterina Maria; Iacolino, Giorgia; Ciaccio, Marcello

doi:10.1080/01616412.2019.1622872

Cited by 131 publications

(87 citation statements)

References 114 publications

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“…Considering the high expression of VDRs in the brain [ 204 ], some studies investigated the correlation between vitamin D deficiency and the onset of neurodegenerative diseases [ 205 , 206 , 207 , 208 ], such as Alzheimer’s [ 209 , 210 , 211 ] and Parkinson’s diseases [ 212 , 213 , 214 ].…”

Section: Vitamin D: State Of the Artmentioning

confidence: 99%

Understanding the Biological Activities of Vitamin D in Type 1 Neurofibromatosis: New Insights into Disease Pathogenesis and Therapeutic Design

Riccardi

Perrone

Napolitano

et al. 2020

Cancers

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Vitamin D is a fat-soluble steroid hormone playing a pivotal role in calcium and phosphate homeostasis as well as in bone health. Vitamin D levels are not exclusively dependent on food intake. Indeed, the endogenous production—occurring in the skin and dependent on sun exposure—contributes to the majority amount of vitamin D present in the body. Since vitamin D receptors (VDRs) are ubiquitous and drive the expression of hundreds of genes, the interest in vitamin D has tremendously grown and its role in different diseases has been extensively studied. Several investigations indicated that vitamin D action extends far beyond bone health and calcium metabolism, showing broad effects on a variety of critical illnesses, including cancer, infections, cardiovascular and autoimmune diseases. Epidemiological studies indicated that low circulating vitamin D levels inversely correlate with cutaneous manifestations and bone abnormalities, clinical hallmarks of neurofibromatosis type 1 (NF1). NF1 is an autosomal dominant tumour predisposition syndrome causing significant pain and morbidity, for which limited treatment options are available. In this context, vitamin D or its analogues have been used to treat both skin and bone lesions in NF1 patients, alone or combined with other therapeutic agents. Here we provide an overview of vitamin D, its characteristic nutritional properties relevant for health benefits and its role in NF1 disorder. We focus on preclinical and clinical studies that demonstrated the clinical correlation between vitamin D status and NF1 disease, thus providing important insights into disease pathogenesis and new opportunities for targeted therapy.

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Section: Vitamin D: State Of the Artmentioning

confidence: 99%

Understanding the Biological Activities of Vitamin D in Type 1 Neurofibromatosis: New Insights into Disease Pathogenesis and Therapeutic Design

Riccardi

Perrone

Napolitano

et al. 2020

Cancers

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show abstract

“…Despite the large number of studies suggesting important functions of vitamin D for brain health, the role(s) of vitamin D in disease remain inconclusive and have sparked some controversy. It is presently not clear whether the findings from animal models reflect physiologically important roles in humans and it has been argued that the data on underlying mechanisms that could explain findings obtained in epidemiological studies are limited . Also, although many studies indicate links between vitamin D and disease, there are also studies describing different results where a connection between altered vitamin D levels and dysfunction was not found .…”

Section: Introductionmentioning

confidence: 99%

“…It is presently not clear whether the findings from animal models reflect physiologically important roles in humans and it has been argued that the data on underlying mechanisms that could explain findings obtained in epidemiological studies are limited . Also, although many studies indicate links between vitamin D and disease, there are also studies describing different results where a connection between altered vitamin D levels and dysfunction was not found . Regarding the effects of vitamin D supplementation on cognitive function and other aspects on brain health, the data appear to be limited or inconsistent .…”

Section: Introductionmentioning

confidence: 99%

Effects of vitamin D in the nervous system: Special focus on interaction with steroid hormone signalling and a possible role in the treatment of brain cancer

Norlin

2019

J Neuroendocrinology

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The active vitamin D hormone, 1,25-dihydroxyvitamin D 3 , exerts many physiological actions in the body, including effects on the nervous system. Studies of steroidogenesis in cells of the nervous system and elsewhere not only indicate that 1,25-dihydroxyvitamin D 3 affects steroidogenic pathways but also suggest varying responses in different cell types. For example, 1,25-dihydroxyvitamin D 3 stimulates the expression of aromatase in human glioma but not in human neuroblastoma cells or rat astrocytes. However, in astrocytes, 1,25-dihydroxyvitamin D 3 suppresses 3β-hydroxysteroid dehydrogenase and steroid 17-hydroxylase/lyase. Other studies indicate cross-talk between vitamin D signalling and signalling of oestrogens, progesterone or glucocorticoids. Reported data indicate synergistic effects of combinations of 1,25-dihydroxyvitamin D 3 and other steroid hormones on neuroinflammation, neurite outgrowth and neuroprotection. Also, dysregulation of steroid pathways affecting brain cells is found in vitamin D deficiency. Thus, several studies suggest that active vitamin D may affect steroid hormone synthesis and/or signalling in the nervous system, although the potential mechanisms for these responses remain unclear.1,25-Dihydroxyvitamin D 3 suppresses proliferation in several cell types and is therefore of interest in cancer treatment. Also, epidemiological studies associate vitamin D levels with cancer risk or outcomes. Reported data on tumours of the nervous system are mainly on glioma, a common type of brain cancer. Expression of the vitamin D receptor in glioma tumours is associated with improved survival. Several studies show that 1,25-dihydroxyvitamin D 3 and vitamin D analogues (synthetic vitamin D-like compounds) suppress proliferation and migration in human vitamin D receptor-expressing glioma cell lines. Studies on mechanisms for actions of 1,25-dihydroxyvitamin D 3 or its analogues indicate regulation of cell cycle proteins and senescence markers. These compounds also show synergism in combination with other cancer therapies treating glioma. From the data available, vitamin D analogues emerge as interesting candidates for the future improved treatment of human glioma and possibly also other cancers of the nervous system. K E Y W O R D Sglioblastoma, growth, steroid hormone, steroidogenesis, vitamin D

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“…Receptors for vitamin D are present on neuronal and glial cells in regions of the brain which have been implicated in the pathophysiology of depression. 8 The role vitamin D plays in neuroimmunomodulation and neuroplasticity, expression of vitamin D receptors in glia and neurons in the central nervous system and its protective effect from psychiatric disorders by causing changes in proliferation in nerve cells through such mechanisms as calcium regulation in neurons and nitric oxide synthase inhibition are well established. [9][10][11] Though the prevalence of vitamin D deficiency is high in all age groups, it is frequently observed especially in women in their reproductive period during and after pregnancy as a result of the need of the developing fetus.…”

Section: Evaluation Of the Relationship Between The Level Of Vitamin mentioning

confidence: 99%

Evaluation of the Relationship Between the Level of Vitamin D in Maternal Blood and Breast Milk and Postpartum Depression

Yuvacı¹,

Yazar²,

Köse³

et al. 2020

J Clin Obstet Gynecol

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This study aimed to evaluate the relationship between postpartum depression (PPD) and vitamin D levels in maternal blood and breast milk. Material and Methods: The study included women who presented to a polyclinic between December 2017 and August 2018, 4-6 weeks after having given live birth, who were aged between 18 and 40 years and married, gave birth after a planned single pregnancy, were feeding their baby with only breast milk and stated that they were taking vitamin D supplementation at the dose recommended by the Ministry of Health. The depression status of the women who agreed to participate in the study by signing the volunteer informed consent form was evaluated using the Edinburgh Postpartum Depression Scale (EPDS). Two groups were formed as Group 1: EPDS score <13 (n=44) (without PPD) and Group 2: EPDS score ≥13 (n=31) (with PPD). The vitamin D levels in breast milk and maternal blood in both groups were compared. Results: 75 female patients included in the study had a mean age of 29.80±4.54 years. The mean vitamin D levels in breast milk and maternal blood were found to be 13.26±5.39 ng/mL and 17.14±6.79 ng/mL, respectively. In terms of depression status, no statistically significant difference was found between the groups regarding the serum vitamin D levels and the mean level of vitamin D in breast milk (p=0.463, p=0.847). Conclusion: No significant correlation was determined between the vitamin D levels in maternal blood and breast milk and PPD, while vitamin D was found to be low both in maternal blood and breast milk.

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Vitamin D and the nervous system

Cited by 131 publications

References 114 publications

Understanding the Biological Activities of Vitamin D in Type 1 Neurofibromatosis: New Insights into Disease Pathogenesis and Therapeutic Design

Understanding the Biological Activities of Vitamin D in Type 1 Neurofibromatosis: New Insights into Disease Pathogenesis and Therapeutic Design

Effects of vitamin D in the nervous system: Special focus on interaction with steroid hormone signalling and a possible role in the treatment of brain cancer

Evaluation of the Relationship Between the Level of Vitamin D in Maternal Blood and Breast Milk and Postpartum Depression

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