Vitamin D and the Renin-Angiotensin System

Li, Yan Chun

doi:10.1016/b978-0-12-381978-9.10040-x

Cited by 6 publications

(2 citation statements)

References 235 publications

(135 reference statements)

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“…In vitro VitD inhibits pancreatic islet RAS component synthesis in parallel to the improvement in beta cell secretory function (53). The VitD induced suppression of renin gene transcription is believed partly to be the mechanism of action (54). Considerable additional evidence supports the theory of VitD induced inhibition of RAS at both systemic and tissue level; for reviews see (54, 55).…”

Section: Tissue Ras Regulationmentioning

confidence: 99%

Tissue Renin–Angiotensin Systems: A Unifying Hypothesis of Metabolic Disease

et al. 2014

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The actions of angiotensin peptides are diverse and locally acting tissue renin–angiotensin systems (RAS) are present in almost all tissues of the body. An activated RAS strongly correlates to metabolic disease (e.g., diabetes) and its complications and blockers of RAS have been demonstrated to prevent diabetes in humans. Hyperglycemia, obesity, hypertension, and cortisol are well-known risk factors of metabolic disease and all stimulate tissue RAS whereas glucagon-like peptide-1, vitamin D, and aerobic exercise are inhibitors of tissue RAS and to some extent can prevent metabolic disease. Furthermore, an activated tissue RAS deteriorates the same risk factors creating a system with several positive feedback pathways. The primary effector hormone of the RAS, angiotensin II, stimulates reactive oxygen species, induces tissue damage, and can be associated to most diabetic complications. Based on these observations, we hypothesize that an activated tissue RAS is the principle cause of metabolic syndrome and type 2 diabetes, and additionally is mediating the majority of the metabolic complications. The involvement of positive feedback pathways may create a self-reinforcing state and explain why metabolic disease initiate and progress. The hypothesis plausibly unifies the major predictors of metabolic disease and places tissue RAS regulation in the center of metabolic control.

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Section: Tissue Ras Regulationmentioning

confidence: 99%

Tissue Renin–Angiotensin Systems: A Unifying Hypothesis of Metabolic Disease

et al. 2014

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“…Effect of vitamin D on coronavirus disease 2019 renin--angiotensin--aldosterone system pathway. Data from [16–21]. Vitamin D has been implicated in regulation of the immune response to viral respiratory agents and is also known to modulate the renin--angiotensin--aldosterone system (RAAS) pathway, including the angiotensin-converting enzyme-2 (ACE2) receptor, which functions as the binding protein for COVID-19.…”

Section: Introductionmentioning

confidence: 99%

Coronavirus disease 2019, vitamin D and kidney function

Szeto

Fan²,

Nickolas

2021

Current Opinion in Nephrology &Amp; Hypertension

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Purpose of reviewThe purpose of this review is to summarize the emerging studies analyzing the association between vitamin D and risk of COVID-19 infection and severity, as well as the early interventional studies investigating the protective effect of vitamin D supplementation against COVID-19.Recent findingsStudies investigating the association between vitamin D levels and risk of COVID-19 infection and risk of severe disease and mortality among those infected have yielded mixed results. Thus far, the majority of studies investigating the association between vitamin D and COVID-19 have been observational and rely on vitamin D levels obtained at the time of admission, limiting causal inference. Currently, clinical trials assessing the effects of vitamin D supplementation in individuals with COVID-19 infection are extremely limited. Randomized, interventional trials may offer more clarity on the protective effects of vitamin D against COVID-19 infection and outcomes.SummaryDecreased levels of vitamin D may amplify the inflammatory effects of COVID-19 infection, yet, data regarding the mortality benefits of vitamin D supplementation in COVID-19-infected individuals are still limited. Current observational data provides the impetus for future studies to including randomized controlled trials to determine whether vitamin D supplementation in COVID-19-infected individuals with kidney disease can improve mortality outcomes.

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Orthomolekulare Therapieoptionen mit Mikronährstoffen bei viralen Atemwegserkrankungen

Passarge,

Schütz

2024

Prävention Und Therapie Viraler Epidemien

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Vitamin D and the Renin-Angiotensin System

Cited by 6 publications

References 235 publications

Tissue Renin–Angiotensin Systems: A Unifying Hypothesis of Metabolic Disease

Tissue Renin–Angiotensin Systems: A Unifying Hypothesis of Metabolic Disease

Coronavirus disease 2019, vitamin D and kidney function

Orthomolekulare Therapieoptionen mit Mikronährstoffen bei viralen Atemwegserkrankungen

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