Vitamin D and Vulnerable Carotid Plaque

McNally, J. Scott; Burton, Tina; Aldred, Booth; Kim, S.-E.; McLaughlin, Michael; Eisenmenger, Laura; Stoddard, Greg; Majersik, Jennifer J.; Miller, Dave; Treiman, Gerald S.; Parker, Dennis L.

doi:10.3174/ajnr.a4849

Cited by 10 publications

(5 citation statements)

References 48 publications

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“…They used multivariable Poisson regression to determine a correlation between two carotid arteries and low Vitamin D levels. As the Vitamin D level increased, there was a significant decrease in the IPH volume in the carotid artery, with a p-value of 0.003, which is less than the alpha value of 0.05(McNally et al 2016). The figures show that Vitamin D decreases the IPH volume and the risk of cardiovascular disease and stroke since it is in the carotid artery.…”

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confidence: 76%

The Effect of Vitamin D on Cardiovascular Disease

Arulkumar¹,

Kethar

2022

J Stud Res

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This research aims to identify the critical factors in the relationship between Vitamin D and coronary heart disease. The hypothesis is that vitamin D can decrease the risk of coronary heart disease. Previous data show how Vitamin D reduces atherosclerosis and homocysteine levels and how Vitamin D incorporates and decreases fat and calcium in the rest of the body, whether through renal excretion or intestinal absorption. It is shown that Vitamin D reduces plaque in the carotid artery as well, which is a more dangerous place for atherosclerosis to occur, as it affects blood flow into the brain. By studying the effect of Vitamin D on the risk of coronary heart disease, this research paper explores possible treatment options that increase Vitamin D levels and reduce the risk of heart attacks, such as getting more sunlight and taking dietary supplements for molecules such as calcitriol.

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confidence: 76%

The Effect of Vitamin D on Cardiovascular Disease

Arulkumar¹,

Kethar

2022

J Stud Res

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“…In contrast to the current results, Chen et al described the association of lower 25OHD levels and the presence of carotid plaques in Chinese type 2 diabetic patients [ 32 ]. Previous cross-sectional studies found an association between lower levels of 25OHD and cIMT [ 12 , 33 , 34 ]. In the large prospective Framingham Offspring Study, vitamin D deficiency was a predictor of cardiovascular disease only in subjects with hypertension.…”

Section: Discussionmentioning

confidence: 98%

Calcium Phosphate Product Is Associated with Subclinical Carotid Atherosclerosis in Type 2 Diabetes

Ramírez‐Morros

Granado-Casas

Alcubierre

et al. 2017

Journal of Diabetes Research

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Aims To assess whether circulating 25-hydroxyvitamin D3 (25OHD) and mineral metabolism-related factors (serum phosphate, calcium, and parathormone) are associated with subclinical carotid atherosclerosis (SCA), defined as the presence of carotid atherosclerotic plaques (main study outcome), in patients with type 2 diabetes mellitus (T2DM) without kidney disease or previous cardiovascular disease. Methods We undertook a post hoc analysis of a cross-sectional study in adults with T2DM in whom we evaluated SCA. A total of 303 subjects with T2DM were included. Clinical variables and carotid ultrasound imaging were obtained. Results We found no association of 25OHD with the presence of SCA. However, calcium phosphate (CaP; mg2/dL2) product was positively associated with the presence of carotid plaques (ORadj = 1.078; 95% CI: 1.017–1.142). An inverse association was observed between higher levels of 25OHD (≥30 ng/mL versus <20 ng/mL concentrations) and common carotid intima-media thickness (cIMT; mm) (βadj ± SE = −0.055 ± 0.024). We conclude that the CaP product is independently associated with the presence of established subclinical carotid atherosclerosis in patients with T2DM.

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“…Animal models also indicate that IPH can be stimulated by angiotensin II administration. 102 In a human study, however, IPH was not associated with angiotensin II levels, but instead with low vitamin D. 103 Vitamin D is a known negative regulator of the angiotensin system and may have local effects on the vessel wall. 104 Although some have postulated that hypertension induces neovessel rupture and IPH, only a few studies have found a link between hypertension and IPH.…”

Section: Additional Markers Of Mri-detected Iphmentioning

confidence: 98%

Magnetic Resonance Imaging Detection of Intraplaque Hemorrhage

McNally

Kim

Mendes

et al. 2017

Magn Reson�Insights

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Carotid artery atherosclerosis is a major cause of ischemic stroke. For more than 30 years, future stroke risk and carotid stroke etiology have been determined using percent diameter stenosis based on clinical trials in the 1990s. In the past 10 years, magnetic resonance imaging (MRI) sequences have been developed to detect carotid intraplaque hemorrhage. By detecting carotid intraplaque hemorrhage, MRI identifies potential stroke sources that are often overlooked by lumen imaging. In addition, MRI can dramatically improve assessment of future stroke risk beyond lumen stenosis alone. In this review, we discuss the use of heavily T1-weighted MRI sequences used to detect carotid intraplaque hemorrhage. In addition, advances in ciné imaging, motion robust techniques, and specialized neck coils will be reviewed. Finally, the clinical use and future impact of MRI plaque hemorrhage imaging will be discussed.

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Vitamin D and Vulnerable Carotid Plaque

Cited by 10 publications

References 48 publications

The Effect of Vitamin D on Cardiovascular Disease

The Effect of Vitamin D on Cardiovascular Disease

Calcium Phosphate Product Is Associated with Subclinical Carotid Atherosclerosis in Type 2 Diabetes

Magnetic Resonance Imaging Detection of Intraplaque Hemorrhage

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