Vitamin D and walking speed in older adults: Systematic review and meta-analysis

Annweiler, Cédric; Henni, Samir; Walrand, Stéphane; Montero‐Odasso, Manuel; Duque, Gustavo; Duval, Guillaume

doi:10.1016/j.maturitas.2017.07.012

Cited by 44 publications

(39 citation statements)

References 53 publications

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“…Vitamin D levels are positively correlated with bone mineral density (BMD) [4]. Many observational studies have reported relations between chronic lower vitamin D concentrations and poorer lower-extremity function, lower muscle strength, lower contraction speed, and lower appendicular muscle mass [8]. Vitamin D deficiency can put people at risk because of low bone mineral density, osteopenia, osteoporosis, and tooth loss [6].…”

Section: Vitamin D and Bone Healthmentioning

confidence: 99%

“…The biological effect of vitamin D on cardiac function is through reduced remodeling and fibrosis secondary to negative regulation of renin by vitamin D receptor (VDR)-linked gene regulation and through reduced cardiac metalloproteinase activities [10]. In addition, many indications support a relation between hypovitaminosis D and slower nerve conduction and poorer executive functions [8]. VDR are also expressed on immune cells (T and B cells, monocytes/macrophages, mast cells, and antigen-presenting cells) [10].…”

Section: Vitamin D and Non-skeletal Diseasesmentioning

confidence: 99%

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Vitamin D and Its Deficiency in Saudi Arabia

Bokhari¹,

Albaik²

2020

Vitamin D Deficiency

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Vitamin D is a hot topic that has attracted attention over the past 10 years, especially since a large proportion of people suffer from this nutrient deficiency. Vitamin D deficiency is estimated to be about 1 billion people all over the world and 50% in Asia and the Middle East. Saudi Arabia has also demonstrated a high prevalence of vitamin D deficiency among healthy Saudi individuals. This chapter provides, in detail, a clear and understandable identification of vitamin D, its function, source, synthesis, metabolism, status, and deficiency. The chapter also focuses on studying vitamin D deficiency in Saudi Arabia based on PubMed's initial research criteria.

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Section: Vitamin D and Bone Healthmentioning

confidence: 99%

Section: Vitamin D and Non-skeletal Diseasesmentioning

confidence: 99%

Vitamin D and Its Deficiency in Saudi Arabia

Bokhari¹,

Albaik²

2020

Vitamin D Deficiency

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“…A serum 25OHD concentration below 50 nmol/L (i.e., vitamin D deficiency) results in skeletal adverse consequences, including decreased bone mineralisation and secondary hyperparathyroidism [2]. Extra-skeletal adverse consequences, such as gait and cognitive impairments have also been reported with low serum 25OHD concentrations between 50 and 75 nmol/L (i.e., vitamin D insufficiency) [3][4][5]. Gait impairments are caused by physiological system impairments that depend, in part, on vitamin D-related metabolism [4][5][6][7].…”

Section: Introductionmentioning

confidence: 99%

Effects of Vitamin D and Calcium Fortified Yogurts on Gait, Cognitive Performances, and Serum 25-Hydroxyvitamin D Concentrations in Older Community-Dwelling Females: Results from the GAit, MEmory, Dietary and Vitamin D (GAME-D2) Randomized Controlled Trial

et al. 2019

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Background: Vitamin D3 fortified food may improve serum vitamin D level, suggesting that the prevention of adverse consequences of hypovitaminosis D is possible with food fortification. The aim of this randomized controlled trial (RCT) was to examine the effects of vitamin D and calcium fortified yogurt on spatiotemporal gait parameters, cognitive performance, handgrip strength, and serum 25OHD levels in healthy older females. Methods: Forty older community-dwelling females were recruited in a single-blind, randomized, controlled, superiority clinical trial in two parallel groups (20 participants in the intervention group and 20 in the control group) with intent-to-treat. The intervention group took fortified yogurts daily (i.e., 400 UI of vitamin D3 and 800 mg calcium) for 3 months. The non-fortified yogurts contained similar proteins, carbohydrates and lipids, as well as a lower dose of calcium (300 mg) and no vitamin D3 supplementation. Spatiotemporal gait parameters (mean value and coefficient of variation) were assessed using a computerized walkway. Handgrip strength was measured with hydraulic dynamometers. Cognitive performances, including global cognitive functioning assessed with the Mini Mental Status Examination (MMSE) were recorded. All the outcomes were assessed at baseline and at the end of follow-up. The primary outcome was the coefficient of variation of stride time. Results: The intervention group maintained its global cognitive performance and serum 25OHD concentrations, whereas these outcomes decreased (i.e., worst performance) in the control group. The changes in the MMSE score (p = 0.022) and serum 25OHD concentrations were different (p ≤ 0.001) with better values reported in the intervention group compared to the control group. There was no significant change in gait parameters (p ≥ 0.518) and handgrip strength (p ≥ 0.600). Conclusions: Fortified yogurts with vitamin D (i.e., 200 IU) and calcium (i.e., 400 mg) twice a day maintained global cognitive performance and vitamin D status in older females, but not gait performances, signifying that they mainly prevent hypovitaminosis D-related extra-skeletal disorders.

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“…The clinical relevance is that hypovitaminosis D is accompanied by adverse health events. For instance, hypovitaminosis D is associated with poorer physical performance in older adults [2,3]. The explanation most commonly offered is based on the possible involvement of vitamin D in muscle health and function [3], as suggested by experimentation reporting the presence of vitamin D receptors (VDRs) in muscle cells [4].…”

Section: Introductionmentioning

confidence: 99%

“…For instance, hypovitaminosis D is associated with poorer physical performance in older adults [2,3]. The explanation most commonly offered is based on the possible involvement of vitamin D in muscle health and function [3], as suggested by experimentation reporting the presence of vitamin D receptors (VDRs) in muscle cells [4]. However, it is noticeable that previous clinical studies on hypovitaminosis D and muscle strength have shown conflicting results [5].…”

Section: Introductionmentioning

confidence: 99%

Association of hypovitaminosis D with triceps brachii muscle fatigability among older women: Findings from the EPIDOS cohort

et al. 2018

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A B S T R A C TBackground: Vitamin D affects physical performance in older adults. Its effects on muscles, notably on muscle strength, remain unclear. The objective of this cross-sectional study was to determine whether hypovitaminosis D is associated with triceps brachii muscle fatigability in community-dwelling older women. Methods: A randomized subset of 744 women aged ≥75years from the EPIDOS cohort was categorized into two groups according to triceps brachii muscle fatigability, defined as loss of strength > 5% between two consecutive maximal isometric voluntary contractions. Hypovitaminosis D was defined using consensual threshold values (i.e., serum 25-hydroxyvitamin D concentration [25OHD] ≤10 ng/mL, ≤20 ng/mL, and ≤30 ng/mL). Age, body mass index, comorbidities, use psychoactive drugs, physical activity, first triceps strength measure, hyperparathyroidism, serum concentrations of calcium, albumin and creatinine, season and study centers were used as potential confounders. Results: The prevalence of hypovitaminosis D ≤ 30 ng/mL was greater among women with muscle fatigability compared with the others (P = .009). There was no between-group difference using the other definitions of hypovitaminosis D. The serum 25OHD concentration was inversely associated with the between-test change in triceps strength (adjusted β = −0.09 N, P = .04). Hypovitaminosis D ≤ 30 ng/mL was positively associated with triceps fatigability (adjusted OR = 3.15, P = .02). Conclusions: Vitamin D concentration was inversely associated with the ability to maintain strength over time in this cohort of community-dwelling older women. This is a relevant new orientation of research toward understanding the involvement of vitamin D in muscle function.

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Vitamin D and walking speed in older adults: Systematic review and meta-analysis

Cited by 44 publications

References 53 publications

Vitamin D and Its Deficiency in Saudi Arabia

Vitamin D and Its Deficiency in Saudi Arabia

Effects of Vitamin D and Calcium Fortified Yogurts on Gait, Cognitive Performances, and Serum 25-Hydroxyvitamin D Concentrations in Older Community-Dwelling Females: Results from the GAit, MEmory, Dietary and Vitamin D (GAME-D2) Randomized Controlled Trial

Association of hypovitaminosis D with triceps brachii muscle fatigability among older women: Findings from the EPIDOS cohort

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