Vitamin D and women’s reproductive health (literature review)

Зайдиева, Я З; Балан, В. Е.

doi:10.21518/2079-701x-2018-12-164-172

Med. sov.

2018

DOI: 10.21518/2079-701x-2018-12-164-172

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Vitamin D and women’s reproductive health (literature review)

Я З Зайдиева¹,

В. Е. Балан²

Abstract: ВВЕДЕНИЕПоявляется все больше свидетельств того, что витамин Д (25(OH)D) поддерживает кальциево-фосфорный гомео-стаз и минерализацию костной ткани [1]. Гиповитаминоз витамина Д связан с повышенным риском развития рака [2], аутоиммунных заболеваний, сахарного диабета, сер-дечно-сосудистых заболеваний [1][2][3], что говорит о важ-ности достаточного количества витамина Д. Есть данные, что в дополнение к половым стероидным гормонам, клас-сическим регуляторам репродуктивного здоровья вита-мин Д также принимает учас… Show more

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Cited by 3 publications

References 113 publications

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Micronutrient deficiency in menstrual dysfunction among women of reproductive age

Sandakova

Zhukovskaya

2021

Perm Medical Journal

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Objective. To determine whether inorganic menstrual dysfunction (MD) is associated with magnesium, iron and vitamin D deficiency in women of reproductive age. Materials and methods. The study group I consisted of 50 women with MD: dysmenorrhea (16 women), oligomenorrhea (12 women), functional hypothalamic amenorrhea (3 patients) and acyclic abnormal uterine bleeding (19 women), the comparison group II was composed of 30 patients with normal menstrual function. The methods of study included history taking using a questionnaire to detect the signs of magnesium deficiency, physical examination, echography of pelvic organs, full blood count, blood tests to determine the concentration of magnesium, vitamin D and ferritin as well as consulting a therapeutist. Results. Magnesium deficiency was registered significantly more often in patients with MD (93.0 3.6 %, 73.0 8.1 %, respectively; p 0.05). The most typical signs of magnesium deficiency were the central symptoms: headache (58.0 7.1 %, 22.0 7.6 %; p 0.001), irritability (53.0 7.1 %, 26.0 8.0 %; p 0.01), dyssomnia (45.0 7.0 %, 17.0 6.9 %; p 0.01), dizziness (42.5 7.0 %, 22.0 7.6 %; p 0.05), a decrease in libido (34.0 6.7 %, 13.0 6.1 %; p 0.05), as well as trophic disturbances including hair loss (38.0 6.9 %, 13.0 6.9 %; p 0.01). Similar findings were obtained when we studied the iron supply: the frequency of latent iron deficiency (according to ferritin concentration) was 77.0 5.9 and 35.7 8.4 % respectively; p 0.001. Deficiency or insufficient supply of 25(ОH)D was registered significantly more often in women with MD in comparison with healthy women (45.0 7.0 %, 20.0 7.3 %; p 0.05). Conclusions. In summary, determination of the level of micronutrients and adequate compensation of their deficiency can be important factors in physiological correction of endocrine imbalance leading to functional disorders in the reproductive system and a decrease in fertility.

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Micronutrient deficiency in menstrual dysfunction among women of reproductive age

Sandakova

Zhukovskaya

2021

Perm Medical Journal

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Effect of vitamin D on women’s somatic and reproductive health

Жуковская

Якупова

2020

Medicinskij sovet

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The article presents the results of a study of the effect of vitamin D deficiency on women’s health.The study aimed to determine the prevalence of vitamin D deficiency and its relationship with the somatic and reproductive health of women.Methods: observation group I included 31 women with a reduced serum vitamin D levels (20.4 ± 1.0 ng/ml), comparison group II included 31 patients with normal vitamin D levels (39.0 ± 1.4 ng/ml). Results: the negative effect of vitamin D deficiency on women’s health is also practically assured, i.e. the incidence of somatic pathology is significantly higher in group I compared with group II: obesity (62.5 ± 12.1% and 18.8 ± 9.8%; p <0.5), insulin resistance (55.0 ± 9.0% and 1.0 ± 6.0%; p <0.001); arterial hypertension (42.0 ± 8.8% and 13.0 ± 6.0%; p <0.01); hypertrophic myocardiopathy (25.8 ± 7.8% and 6.4 ± 4.4%; p <0.05); chronic colitis (29.0 ± 8.1% and 6.4 ± 4.4%; p <0.05), gastric ulcer (22.5 ± 7.5% and 3.2 ± 3.2%; p <0.05), chronic pancreatitis (22.5 ± 7.5% and 3.2 ± 3.2%; p <0.05), chronic gastritis (25.8 ± 7.8% and 9.7 ± 5.3%; p <0.1). The interaction between reduced vitamin D levels and reproductive system diseases is confirmed by significant increase in the prevalence of secondary amenorrhea (80.0 ± 9.0% and 16.0 ± 7.3%; p <0.001), secondary oligomenorrhea (75.0 ± 9.7% and 20.0 ± 8.0%; p <0.001), hyperplastic processes – uterine fibroids (48.4 ± 9.0% and 13.3 ± 6.1%; p <0.001) and adenomyosis (26.6 ± 7.9% and 6.7 ± 4.5%; p <0.05), polycystic ovary syndrome (29.0 ± 8.2% and 6.7 ± 4.5%; p <0.05), vaginal microbiocenosis disorders (aerobic vaginitis – 42.0 ± 8.9% and 16.1 ± 6.6%; p <0.05; bacterial vaginosis – 29.0 ± 8.2% and 9.7 ± 5.3%; p <0.05).Conclusion: management of vitamin D level is one of the priorities in the formation of therapeutic and preventive measures to improve the women’s health.

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Indicators of carbohydrate metabolism and vitamin D levels in pregnant women with metabolic syndrome

Akhundova¹

2022

RHW

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The objective: to assess the level of vitamin D and its relationship with carbohydrate metabolism in women with metabolic syndrome in the I trimester of pregnancy. Materials and methods. 120 pregnant women were examined, of which 60 patients were diagnosed with metabolic syndrome before pregnancy (main group) and 60 patients without this pathology (control group). All women were measured for fasting blood glucose, glycated hemoglobin, immunoreactive insulin, HOMA-IR index, and serum vitamin D levels. Results. In women in the main group, the average level of vitamin D was 15.76±3.77 ng/ml, in the control group – 17.20±3.76 ng/ml. The concentration of vitamin D less than 20 ng/ml in the main group was found in 70.0% of patients, in the control group – in 51.7%, 20–30 ng/ml – in 30.0% and 48.3%, respectively (p<0.05). The mean body mass index was significantly higher in women of the main group relative to the control group (p=0.041) and in patients with metabolic syndrome did not differ from the values in women with vitamin D deficiency and insufficiency. However, body mass index was significantly higher in the presence of vitamin D deficiency between patients with and without metabolic syndrome (p=0.001). There was a significant difference in the concentration of immunoreactive insulin and the value of the HOMA-IR index between pregnant women with vitamin D deficiency and metabolic syndrome (p=0.040) and without it (p=0.023). Serum 25(OH)D levels in early pregnancy in persons with metabolic syndrome positively correlated with glucose (r=0.361; p>0.05), HbA1c (r=0.355; p>0.05) and HOMA-IR (r=0.239; p>0.05) in vitamin D deficiency and negative in 25(OH)D insufficiency: r=-0.795 (p<0.05), r=-0.464 (p>0.05) and r=-0.500 (p>0.05), respectively.Conclusions. Pregnant women with metabolic syndrome and vitamin D deficiency, compared with pregnant women without this syndrome, may have higher levels of immunoreactive insulin and HOMA-IR index. Between the women with the deficiency and insufficiency of vitamin D and the parameters of carbohydrate metabolism in the metabolic syndrome a multidirectional correlation was revealed.

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Vitamin D and women’s reproductive health (literature review)

Cited by 3 publications

References 113 publications

Micronutrient deficiency in menstrual dysfunction among women of reproductive age

Micronutrient deficiency in menstrual dysfunction among women of reproductive age

Effect of vitamin D on women’s somatic and reproductive health

Indicators of carbohydrate metabolism and vitamin D levels in pregnant women with metabolic syndrome

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