Vitamin D and Your Patients

Roizen, Michael F.; Roizen, Jeffrey D.

doi:10.1213/ane.0000000000000285

Cited by 5 publications

(3 citation statements)

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“…The lack of PTH response indicates that calcium in conjunction with other factors may blunt the normal PTH response. Calcium is a known regulator of 1‐alpha hydroxylase activity and PTH secretion . Albumin corrected calcium increased significantly after surgery and could theoretically augment the observed 35% decrease in serum 1,25(OH) 2 D 3 .…”

Section: Discussionmentioning

confidence: 99%

“…A persistent impairment of 1α‐hydroxylase activity is important because it cannot be bypassed by treating patients with simple vitamin D supplementation. This may occur at a critical time for these orthopedic patients because optimal bone function is essential for primary bony fixation by ingrowth of uncemented prostheses to avoid aseptical loosening . To demonstrate whether DBP is altered in response to surgical stress and if activation of vitamin D also is compromised, we conducted a detailed investigation of the changes in serum DBP, total and free vitamin D metabolites, calcium, and PTH and compared them with changes in sex steroids and gonadotropins before and after elective total knee arthroplasty (TKA).…”

Section: Introductionmentioning

confidence: 99%

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Compromised Activation of Vitamin D After Elective Surgery: A Prospective Pilot Study

et al. 2018

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Surgical stress reduces concentrations of most proteins in serum and necessitates a rapid adjustment of hormones dependent on protein binding. Activation of vitamin D by renal 1α‐hydroxylation is dependent on protein binding because 1,25‐dihydroxyvitamin D (1,25(OH)2D3) is formed after megalin‐mediated reabsorption of 25‐hydroxyvitamin D (25OHD) bound to vitamin D binding protein (DBP). Postoperative alterations in serum concentrations of DBP and albumin may therefore impair 1,25(OH)2D3 production. Our objective was to determine sex‐specific changes in serum concentrations of vitamin D metabolites and sex steroids 2, 6, 24, and 48 hours and 3 weeks postoperatively. Fourteen women and eleven men aged 45 to 77 years without severe comorbidities undergoing unilateral total knee arthroplasty participated in this prospective study in a tertiary center for arthroplasty (trial ID: NCT02336932). The main outcome measures were total and free serum concentrations of 25OHD, 1,25(OH)2D3, 24,25‐dihydroxyvitamin‐D, DBP, albumin, sex hormone binding globulin (SHBG), calcium, and parathyroid hormone (PTH). Serum albumin and SHBG decreased postoperatively (Δalbumin48h −18% [−22%; −14%]). Unexpectedly, concentrations of DBP and 25OHD remained unaltered, but 1,25(OH)2D3 declined postoperatively. 1,25(OH)2D3 was 3 weeks after surgery −24% (−40%; −8%) lower than preoperative levels, whereas 24,25‐dihydroxyvitamin‐D remained unchanged in postmenopausal women. The calculated conversion rate of 25OHD to 1,25(OH)2D3 was strongly associated with serum 25‐OHD and PTH preoperatively, whereas serum calcium was most predictive postoperatively. In conclusion, surgery had no effect on serum concentrations of DBP, 25OHD, and PTH, whereas production of 1,25(OH)2D3 was markedly reduced. Further studies are needed to determine duration and putative outcome effects of this postoperative 1,25(OH)2D3 deficit in women, which in part may be due to discordance in CYP27B1 and CYP24A1 activity. © 2018 American Society for Bone and Mineral Research.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Compromised Activation of Vitamin D After Elective Surgery: A Prospective Pilot Study

et al. 2018

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“…This program opens for everyone to measure their beauty and they will be received high score when close to the original data or golden rectangle proportion. (Roizen, Oz, Roizen, & Roizen, 2011)From this research we will know that the beauty and attractiveness also depends on the generation and social culture and beauty or attractiveness may change the standard of measuring all the time.…”

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Does attractiveness have an increasing probability on hiring decision?�Case study on Marketing position in Financial Business

Sukcharoen

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This research provides new evidence the impact between beauty and hiring decision in the labor market. Specifically,�study if people with less attractive faces are less likely to be chosen after submitting a resume. The empirical strategy is based on an experimental approach by making an application that has attractive and unattractive photos for human resource workers in financial business in Bangkok, Thailand. For rating of the application that wants to choose from highest to lowest from all applications. From the results, it is found that applications with attractive images will be selected higher than applications with unattractive photos. But the factors that have been chosen the most is factor of language ability.

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Shafer¹

2015

Anesthesia &Amp; Analgesia

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Vitamin D and Your Patients

Cited by 5 publications

References 15 publications

Compromised Activation of Vitamin D After Elective Surgery: A Prospective Pilot Study

Compromised Activation of Vitamin D After Elective Surgery: A Prospective Pilot Study

Does attractiveness have an increasing probability on hiring decision?�Case study on Marketing position in Financial Business

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